Etiology-guided mutational signature learning from DNA repair knockouts in cell lines using supervised NMF [0.03%]
基于细胞系DNA修复敲除的监督NMF指导的病因突变标志学习方法
Sander Goossens,Yasin I Tepeli,Colm Seale et al.
Sander Goossens et al.
Many tumours show deficiencies in DNA damage response (DDR), not only driving tumorigenesis but also exposing vulnerabilities with therapeutic potential. Assessing which patients might benefit from DDR-targeting therapy requires knowledge o...
Unveiling the terra cognita of sequence spaces using Cartesian projection of asymmetric distances [0.03%]
基于非对称距离的笛卡尔投影揭示序列空间的新知之地
Alban Ramette
Alban Ramette
Visualizing relationships within massive biological datasets remains a significant challenge, particularly as sequence length and volume increase. We introduce CAPASYDIS (Cartesian Projections of Asymmetric Distances), a scalable approach d...
The promise of long-read RNA-seq: reducing bias in analyses of allele imbalance [0.03%]
长读RNA测序的前景：降低等位基因不平衡分析中的偏差
Nadja Nolte,Marko Petek,Pablo Angulo Lara et al.
Nadja Nolte et al.
Inaccurate allele and gene expression counts due to map bias and genome ambiguity lead to high false positive and false negative rates in studies of allelic imbalance. We demonstrate that long read RNA sequencing (RNA-seq) and straightforwa...
Correction to 'A landscape of metallophore synthesis and uptake potential of the genus Staphylococcus' [0.03%]
关于“金属配体合成和摄取能力的地景图——葡萄球菌属”的更正通知
[This corrects the article DOI: 10.1093/nargab/lqaf183.]. © The Author(s) 2026. Published by Oxford University Press.
Published Erratum
NAR genomics and bioinformatics. 2026 Jul 30;8(3):lqag091. DOI:10.1093/nargab/lqag091 2026
Characterizing highly conserved fragments in 3'UTRs via statistical and transfer learning approaches [0.03%]
基于统计和迁移学习方法的3'UTR高保守片段特征研究
Eric S Ho,Ash Baeck-Hubloux,Nathan Dinh et al.
Eric S Ho et al.
3' Untranslated regions (3'UTRs) serve as regulatory platforms that modulate steps in the central dogma through the binding of RNA-binding proteins and miRNAs. Their binding sites are often identified through orthologous regions among speci...
A theoretical and experimental framework enables low-coverage sequencing for accurate quantification of genome-wide cytosine modification levels [0.03%]
一种理论和实验框架使低覆盖率测序能够准确量化全基因组胞嘧啶修饰水平成为可能
Christian E Loo,Johanna M Fowler,Heqiao Zhu et al.
Christian E Loo et al.
5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) regulate gene expression and exhibit dynamic levels during development and disease. While high-depth, base-resolution studies offer the most detailed view of epigenetic landscapes, m...
bMINTY: enabling reproducible management of high-throughput sequencing analysis results and their metadata [0.03%]
bMINTY：启用高通量测序分析结果及其元数据的可重复管理
Konstantinos Kapelios,Haris Manousaki,Vasiliki Kotsira et al.
Konstantinos Kapelios et al.
Due to the large scale of high-throughput sequencing data generation, the community has established standards that promote Findable, Accessible, Interoperable and Reusable (FAIR) science. However, critical obstacles remain since best practi...
Cell-type-resolved RNA-seq reveals molecular signatures of sexual experience in Drosophila neuromodulatory neurons [0.03%]
单细胞分辨率的RNA测序揭示了果蝇神经调节神经元中交配体验的分子标志物
Julia Ryvkin,Anat Shmueli,Ayalla Aharony et al.
Julia Ryvkin et al.
Flexible behavioral responses depend on the ability of neural circuits to adapt their physiology and output to changing social and environmental contexts. Neuromodulation is central to this flexibility, yet how specific experiences are enco...
metaWEPP: leveraging biobank-scale intra-species phylogenies for near-haplotype resolution in metagenomic analysis [0.03%]
利用大规模生物库的种内系统发育树进行宏基因组分析的近乎单倍型分辨率研究-metaWEPP工具箱
Pranav Gangwar,Qiwen Xu,Jaden Seangmany et al.
Pranav Gangwar et al.
Metagenomic sequencing is transforming diverse areas of health and biological sciences, including pathogen surveillance, clinical diagnostics, and microbiome research. However, the inherent complexity of metagenomic data limits most computa...
Correction to 'Challenges in predicting chromatin accessibility differences between species' [0.03%]
对“预测染色质可及性差异的挑战”的修正
[This corrects the article DOI: 10.1093/nargab/lqag059.]. © The Author(s) 2026. Published by Oxford University Press.
Published Erratum
NAR genomics and bioinformatics. 2026 Jul 21;8(3):lqag083. DOI:10.1093/nargab/lqag083 2026