Eul Hyun Suh,James Ratnakar,Jaspal Singh et al.
Eul Hyun Suh et al.
77Se is a spin ½, low sensitivity nucleus with a natural abundance of 7.6%. Although 77Se NMR is very useful in the characterization of selenium containing molecules including seleno-proteins, the detection of 77Se is challenging in biolog...
Homogeneous Catalysts for Hydrogenative PHIP Used in Biomedical Applications [0.03%]
用于生物医学应用的氢解PHIP均相催化剂
Mai T Huynh,Zoltan Kovacs
Mai T Huynh
At present, two competing hyperpolarization (HP) techniques, dissolution dynamic nuclear polarization (DNP) and parahydrogen (para-H2) induced polarization (PHIP), can generate sufficiently high liquid state 13C signal enhancement for in vi...
Rapid Characterization of Phospholipids from Biological Matrix Enabled by Indium Tin Oxide (ITO) Coated Slide Assisted Enrichment MALDI Mass Spectrometry [0.03%]
基于氧化铟锡(ITO)涂覆载片辅助富集的基质辅助激光解吸/电离质谱技术快速表征生物基质中的磷脂分子
Penghsuan Huang,Hua Zhang,Yuan Liu et al.
Penghsuan Huang et al.
Lipidomic analysis of human serum is essential to monitor the individual's health status. Herein, we develop a facile strategy for rapid characterization of phospholipids in human serum via indium tin oxide (ITO) coated glass slide solid ph...
Structural Elucidation and Relative Quantification of Fatty Acid Double Bond Positional Isomers in Biological Tissues Enabled by Gas-Phase Charge Inversion Ion/Ion Reactions [0.03%]
基于气相电荷翻转反应的生物组织中脂肪酸双键位置异构体结构阐明及相对定量研究
Julia R Bonney,Boone M Prentice
Julia R Bonney
Fatty acids (FAs) contain a vast amount of structural diversity, and differences in fatty acid structure have been associated with various disease states. Accurate identification and characterization of fatty acids is critical to fully unde...
LC-MS Reveals Isomeric Inhibition of Proteolysis by Lysosomal Cathepsins [0.03%]
LC-MS揭示溶酶体半胱氨酸蛋白酶的异构抑制作用中的肽键断裂
Gaurav Pandey,Ryan R Julian
Gaurav Pandey
Defects in autophagy are implicated in many age-related diseases that cause neurodegeneration including both Alzheimer's and Parkinson's. Within autophagy, the lysosome plays a crucial role by enabling the breakdown and recycling of a wide ...
Copper-Catalyzed Covalent Dimerization of Near-Infrared Fluorescent Cyanine Dyes: Synergistic Enhancement of Photoacoustic Signals for Molecular Imaging of Tumors [0.03%]
铜催化近红外荧光cyanine染料共价二聚化：用于肿瘤分子成像的光声信号协同增强
Dolonchampa Maji,Donghyeon Oh,Krishna Sharmah Gautam et al.
Dolonchampa Maji et al.
Photoacoustic (PA) imaging relies on the absorption of light by chromophores to generate acoustic waves used to delineate tissue structures and physiology. Here, we demonstrate that Cu(II) efficiently catalyzes the dimerization of diverse n...
Detection of Ethylene with Defined Metal Complexes: Strategies and Recent Advances [0.03%]
用定义金属配合物检测乙烯：策略及近期进展
Katrina H Jensen,Brian W Michel
Katrina H Jensen
Despite its relative simplicity, ethylene is an interesting molecule with wide-ranging impact in modern chemistry and biology. Stemming from ethylene's role as a critical plant hormone, there has been significant effort to develop selective...
Designing Protein-Based Probes for Sensing Biological Analytes with Magnetic Resonance Imaging [0.03%]
基于蛋白质的磁共振成像生物分子探针的设计
Jason Yun,Michelle Baldini,Rochishnu Chowdhury et al.
Jason Yun et al.
Genetically encoded sensors provide unique advantages for monitoring biological analytes with molecular and cellular-level specificity. While sensors derived from fluorescent proteins represent staple tools in biological imaging, these prob...
Identification of Proteins Using Supramolecular Gold Nanoparticle-Dye Sensor Arrays [0.03%]
基于超分子金纳米粒子-染料传感器阵列的蛋白质鉴别技术
Mingdi Jiang,Aarohi Gupta,Xianzhi Zhang et al.
Mingdi Jiang et al.
The rapid detection of proteins is very important in the early diagnosis of diseases. Gold nanoparticles (AuNPs) can be engineered to bind biomolecules efficiently and differentially. Cross-reactive sensor arrays have high sensitivity for s...
Oxygen-Sensing Chemiluminescent Iridium(III) 1,2-Dioxetanes: Unusual Coordination and Activity [0.03%]
氧敏化学发光铱(III)1,2-二氧烷：不寻常的配位和活性
Husain N Kagalwala,Lorena Bueno,Hashini Wanniarachchi et al.
Husain N Kagalwala et al.
Next generation chemiluminescent iridium 1,2-dioxetane complexes have been developed which consist of the Schaap's 1,2-dioxetane scaffold directly attached to the metal center. This was achieved by synthetically modifying the scaffold precu...