Increased mAb production in amplified CHO cell lines is associated with increased interaction of CREB1 with transgene promoter [0.03%]
与转基因启动子相互作用的CREB1增多可提高CHO细胞系中mAb产量
Hussain Dahodwala,Prashant Kaushik,Vijay Tejwani et al.
Hussain Dahodwala et al.
Most therapeutic monoclonal antibodies in biopharmaceutical processes are produced in Chinese hamster ovary (CHO) cells. Technological advances have rendered the selection procedure for higher producers a robust protocol. However, informati...
A point-of-care assay for alpha-1-acid glycoprotein as a diagnostic tool for rapid, mobile-based determination of inflammation [0.03%]
用于炎症快速诊断的α1酸性糖蛋白床边测定法
Bryan M Gannon,Marshall J Glesby,Julia L Finkelstein et al.
Bryan M Gannon et al.
Background: Inflammation is a key component of immune response to infections and pathogenesis of metabolic and cardiovascular diseases. Inflammatory biomarkers, including alpha-1-acid glycoprotein (AGP), are considered pr...
A Markov model of glycosylation elucidates isozyme specificity and glycosyltransferase interactions for glycoengineering [0.03%]
糖基化马尔可夫模型阐明了糖基转移酶的同工酶特异性和酶相互作用以进行glycoengineering
Chenguang Liang,Austin W T Chiang,Anders H Hansen et al.
Chenguang Liang et al.
Glycosylated biopharmaceuticals are important in the global pharmaceutical market. Despite the importance of their glycan structures, our limited knowledge of the glycosylation machinery still hinders controllability of this critical qualit...