Phenotyping senescent mesenchymal stromal cells using AI image translation [0.03%]
利用AI图像翻译技术表型衰老的间充质基质细胞
Leya Weber,Brandon S Lee,Sara Imboden et al.
Leya Weber et al.
Mesenchymal stromal cells (MSCs) offer promising potential in biomedical research, clinical therapeutics, and immunomodulatory therapies due to their ease of isolation and multipotent, immunoprivileged, and immunosuppersive properties. Exte...
CRISPR-based gene editing of non-homologous end joining factors biases DNA repair pathway choice toward single-strand annealing in Aedes aegypti [0.03%]
基于CRISPR的基因编辑非同源末端连接因子使DNA修复途径偏向于塞孔素连接在埃及伊蚊中
Keun Chae,Justin M Overcash,Chanell Dawson et al.
Keun Chae et al.
To maintain genome stability, eukaryotic cells orchestrate DNA repair pathways to process DNA double-strand breaks (DSBs) that result from diverse developmental or environmental stimuli. Bias in the selection of DSB repair pathways, either ...
Nucleocapsid protein binding DNA aptamers for detection of SARS-COV-2 [0.03%]
用于检测SARS-COV-2的核壳蛋白结合DNA适配体
Charles P Neff,Mile Cikara,Brian J Geiss et al.
Charles P Neff et al.
The severe acute respiratory syndrome coronavirus (SARS-CoV-2) has infected millions of individuals and continues to be a major health concern worldwide. While reverse transcription-polymerase chain reaction remains a reliable method for de...
A review of portable quantitative and semi-quantitative devices for measurement of vitamin A in biological samples [0.03%]
便携式定量和半定量装置测定生物样本中维生素A的研究进展
Samantha L Huey,Jesse T Krisher,David Morgan et al.
Samantha L Huey et al.
Background: We catalog and summarize evidence of the analytical performance of portable quantitative and semi-quantitative devices for the assessment of vitamin A status and vitamin A deficiency (VAD) in various biologica...
The role of SARS-CoV-2 immunosuppression and the therapy used to manage COVID-19 disease in the emergence of opportunistic fungal infections: A review [0.03%]
SARS-CoV-2的免疫抑制及其用于治疗COVID-19疾病的药物在机会性真菌感染中的作用：综述
Nahid Akhtar,Atif Khurshid Wani,Surya Kant Tripathi et al.
Nahid Akhtar et al.
Since December 2019 SARS-CoV-2 infections have affected millions of people worldwide. Along with the increasing number of COVID-19 patients, the number of cases of opportunistic fungal infections among the COVID-19 patients is also increasi...
Highly portable quantitative screening test for prostate-specific antigen at point of care [0.03%]
一种用于护理点前列腺特异性抗原的高便携性定量筛查试验
Balaji Srinivasan,David M Nanus,David Erickson et al.
Balaji Srinivasan et al.
Prostate cancer (PCa) is the second most diagnosed cancer among men. Targeted PCa screening may decrease PCa-specific mortality. Prostate-specific antigen (PSA) is the most reliable and widely accepted tumor biomarker for screening and moni...
An isothermal amplification-based point-of-care diagnostic platform for the detection of Mycobacterium tuberculosis: A proof-of-concept study [0.03%]
基于等温扩增的结核病床旁诊断平台的概念验证研究
Rathina Kumar Shanmugakani,Wesley Bonam,David Erickson et al.
Rathina Kumar Shanmugakani et al.
The timely diagnosis of active tuberculosis disease (TB) is crucial to interrupt the transmission and combat the spread of Mycobacterium tuberculosis (Mtb), the causative agent for TB. Here, we demonstrate the development of a specimen-dire...
PEPTIDE-MODIFIED CHONDROITIN SULFATE REDUCES COEFFICIENT OF FRICTION AT ARTICULAR CARTILAGE SURFACE [0.03%]
肽修饰的硫酸软骨素可降低关节表面摩擦系数
Celina Twitchell,Tanaya Walimbe,Julie C Liu et al.
Celina Twitchell et al.
Osteoarthritis is a debilitating disease that results in pain and joint stiffness. Currently, steroidal and nonsteroidal anti-inflammatory drugs and supplements aimed at restoring lubrication to the affected joint are the most successful wi...
DNA damage measurements within tissue samples with Repair Assisted Damage Detection (RADD) [0.03%]
基于组织样本的RADD(DNA修复辅助损伤检测)损伤测量方法
Kevin J Lee,Elise Mann,Luciana Madeira da Silva et al.
Kevin J Lee et al.
Exposures to genotoxic carcinogens and reactive species result in strand breaks and a spectrum of covalent modifications to DNA that can induce mutations and contribute to the initiation and progression of cancer. Measurements of DNA damage...
Restoration of wild-type motility to flagellin-knockout Escherichia coli by varying promoter, copy number and induction strength in plasmid-based expression of flagellin [0.03%]
通过在质粒中调控鞭毛蛋白表达的启动子、拷贝数和诱导强度来恢复缺失鞭毛蛋白的大肠杆菌野生型菌株的运动性研究
Nicholas M Thomson,Mark J Pallen
Nicholas M Thomson
Flagellin is the major constituent of the flagellar filament and faithful restoration of wild-type motility to flagellin mutants may be beneficial for studies of flagellar biology and biotechnological exploitation of the flagellar system. H...