A point-of-care biosensor for rapid and ultra-sensitive detection of SARS-CoV-2 [0.03%]
一种检测SARS-CoV-2的快速超灵敏型床边式生物传感器
Xinyuan Zhou,Zhenjie Xue,Tie Wang
Xinyuan Zhou
In a recent study in Nature Biomedical Engineering, Wei's group constructed a field-effect transistor (FET) based on the "molecular electromechanical system" (MolEMS). MolEMS enabled FETs to specifically capture viral nucleic acids and effi...
CryoFold: determining protein structures and data-guided ensembles from cryo-EM density maps [0.03%]
基于低温电子显微镜密度图确定蛋白质结构和数据指导的集合:CryoFold
Mrinal Shekhar,Genki Terashi,Chitrak Gupta et al.
Mrinal Shekhar et al.
Cryo-electron microscopy (EM) requires molecular modeling to refine structural details from data. Ensemble models arrive at low free-energy molecular structures, but are computationally expensive and limited to resolving only small proteins...
Kristen D Popowski,Adele Moatti,Grant Scull et al.
Kristen D Popowski et al.
Respiratory diseases are a global burden, with millions of deaths attributed to pulmonary illnesses and dysfunctions. Therapeutics have been developed, but they present major limitations regarding pulmonary bioavailability and product stabi...
Discovering giant magnetoelasticity in soft matter for electronic textiles [0.03%]
用于电子纺织品的软磁电材料中的巨磁弹效应研究
Guorui Chen,Xun Zhao,Sahar Andalib et al.
Guorui Chen et al.
We discovered a giant magnetoelasticity in soft matter with up to 5-fold enhancement of magnetomechanical coupling factors compared to that of rigid metal alloys without an externally applied magnetic field. A wavy chain analytical model ba...
Injectable Liposome-based Supramolecular Hydrogels for the Programmable Release of Multiple Protein Drugs [0.03%]
用于多种蛋白质药物可控释放的可注射超分子水凝胶脂质体
Santiago Correa,Abigail K Grosskopf,John H Klich et al.
Santiago Correa et al.
Directing biological functions is at the heart of next-generation biomedical initiatives in tissue and immuno-engineering. However, the ambitious goal of engineering complex biological networks requires the ability to precisely perturb spec...
Andrew J Robinson,Alejandra Pérez-Nava,Shan C Ali et al.
Andrew J Robinson et al.
Fabrication of anisotropic materials is highly desirable in designing biomaterials and tissue engineered constructs. Electrospinning has been broadly adopted due to its versatility in producing non-woven fibrous meshes with tunable fiber di...
Freeform Cell-Laden Cryobioprinting for Shelf-Ready Tissue Fabrication and Storage [0.03%]
自由成型的含细胞冷冻生物打印技术在组织制造和存储中的应用
Hossein Ravanbakhsh,Zeyu Luo,Xiang Zhang et al.
Hossein Ravanbakhsh et al.
One significant drawback of existing bioprinted tissues is their lack of shelf-availability caused by complications in both fabrication and storage. Here, we report a cryobioprinting strategy for simultaneously fabricating and storing cell-...
Yiwei Li,Wenhui Tang,Ming Guo
Yiwei Li
Viewing cell as matter to understand the intracellular biomolecular processes and multicellular tissue behavior represents an emerging research area at the interface of physics and biology. Cellular material displays various physical and me...
Inhaled hydrogel-based microspheres for management of COVID-19: A new sweeper biological platform [0.03%]
吸入式生物可降解微球用于新冠治疗：一类新的清扫生物平台药剂
Ruoyu Cheng,Hélder A Santos
Ruoyu Cheng
The cytokine storm caused by SARS-CoV-2 infection threatens the condition of patients, even leading to death. In a recent issue of Matter, Prof. Wenguo Cui and co-workers have prepared lung-sweeper inhaled hydrogel microspheres for intratra...
Xuexiang Zhang,Mohammad Mahdi Hasani-Sadrabadi,Jana Zarubova et al.
Xuexiang Zhang et al.
Periodontal diseases are caused by microbial infection and the recruitment of destructive immune cells. Current therapies mainly deal with bacteria elimination, but the regeneration of periodontal tissues remains a challenge. Here we develo...