Matrix stiffness regulates traction forces, cytoskeletal dynamics, and collagen reorganization in trabecular meshwork cells in glaucoma [0.03%]
基质刚度调节矩阵粘附力学特性及小梁网细胞胶原纤维排列在青光眼发病机制中的作用
Alireza Karimi,Mini Aga,Ansel Stanik et al.
Alireza Karimi et al.
Increased adhesion forces between trabecular meshwork (TM) cells and the extracellular matrix (ECM) in the human outflow pathway are associated with elevated intraocular pressure (IOP), a key risk factor for primary open-angle glaucoma (POA...
Cell Contractile Forces Drive Spatiotemporal Morphogenesis in 4D Bioprinted Living Constructs [0.03%]
细胞收缩力驱动4D生物打印活体结构的时空形态发生学演变
Aixiang Ding,David S Cleveland,Kaelyn L Gasvoda et al.
Aixiang Ding et al.
Current 4D materials typically rely on external stimuli such as heat or light to accomplish changes in shape, limiting the biocompatibility of these materials. Here, a composite bioink consisting of oxidized and methacrylated alginate (OMA)...
Autonomous Discovery of Functional Random Heteropolymer Blends through Evolutionary Formulation Optimization [0.03%]
通过进化配方优化自主发现功能随机杂聚物组合物
Guangqi Wu,Tianyi Jin,Alfredo Alexander-Katz et al.
Guangqi Wu et al.
While developing new polymers typically requires years of investigation, blending existing polymers offers a cost-effective strategy to create new materials. However, developing functional polymer blends is often a slow and challenging proc...
Sustained exposure to multivalent antigen-decorated nanoparticles generates broad anti-coronavirus responses [0.03%]
带有多种抗原的纳米粒子的持续暴露可产生广谱抗冠状病毒反应
Julie Baillet,John H Klich,Ben S Ou et al.
Julie Baillet et al.
The threat of future coronavirus pandemics requires developing effective vaccine technologies that provide broad and long-lasting protection against circulating and emerging strains. Here we report a multivalent liposomal hydrogel vaccine t...
Sustainable Conversion of Husk into Viscoelastic Hydrogels for Value-Added Biomedical Applications [0.03%]
稻壳可持续转化为用于高附加值生物医学应用的粘弹性水凝胶
Changxu Sun,Jiping Yue,Pengju Li et al.
Changxu Sun et al.
Natural plants provide a wealth of valuable materials for healthcare, with much of their potential often overlooked in what is commonly considered waste. This study focuses on the Malva Nut Tree (Sterculia lychnophora Hance), whose fruit, P...
Tension in the ranks: Cooperative cell contractions drive force-dependent collagen assembly in human fibroblast culture [0.03%]
细胞内的张力：协同的细胞收缩驱动人成纤维细胞培养中与力量相关的胶原蛋白组装
Alexandra A Silverman,Jason D Olszewski,Seyed Mohammad Siadat et al.
Alexandra A Silverman et al.
Currently, there is no mechanistic model that fully explains the initial synthesis and organization of durable animal structure. As a result, our understanding of extracellular matrix (ECM) development and pathologies (e.g., persistent fibr...
Innate immunity-modulating nanobiomaterials for controlling inflammation resolution [0.03%]
用于控制炎症消退的固有免疫调节纳米生物材料
Yongjiang Li,Wei Chen,Seyoung Koo et al.
Yongjiang Li et al.
The acute inflammatory response is an inherent protective mechanism, its unsuccessful resolution can contribute to disease pathogenesis and potentially lead to death. Innate immune cells are the first line of host defenders and play a subst...
Erratum: Ultrathin Metal-Organic-Layer Mediated Radiotherapy-Radiodynamic Therapy [0.03%]
致读者的一封信：超薄金属有机层介导的放射疗法-放射动力疗法
Kaiyuan Ni,Guangxu Lan,Christina Chan et al.
Kaiyuan Ni et al.
[This corrects the article PMC7442115.].
Published Erratum
Matter. 2024 May 1;7(5):1909. DOI:10.1016/j.matt.2024.04.003 2024
Stiff Hydrogel Encapsulation Retains Mesenchymal Stem Cell Stemness for Regenerative Medicine [0.03%]
刚性水凝胶包封保持间充质干细胞的干性以用于再生医学
Bo Li,Liyuan Zhang,Yuan Yin et al.
Bo Li et al.
Mesenchymal stem cell (MSC) stands as a prominent choice in regenerative medicine, yet their therapeutic potential remains controversial due to challenges in maintaining lineage and viability. As directly injected MSCs are quickly cleared b...
Alex Lammers,Heng-Hua Hsu,Subramanian Sundaram et al.
Alex Lammers et al.
Tissue engineering has long sought to rapidly generate perfusable vascularized tissues with vessel sizes spanning those seen in humans. Current techniques such as biological 3D printing (top-down) and cellular self-assembly (bottom-up) are ...