Intra-tracheal delivery of AAV6 vectors results in sustained transduction in murine lungs without genomic integration [0.03%]
AAV6载体的气道内递送可实现小鼠肺部的持续转导且没有基因组整合
Yanerys Colon-Cortes,Mutasim Abu Hasan,George Aslanidi
Yanerys Colon-Cortes
Despite the progress made in AAV-based gene therapy targeting different organ systems, lung-targeted gene therapy using AAV vectors has not been effective, mostly due to the poor transduction and un-sustained gene expression in airway epith...
Time-series analyses of directional sequence changes in SARS-CoV-2 genomes and an efficient search method for candidates for advantageous mutations for growth in human cells [0.03%]
SARS-CoV-2基因组方向序列变化的时间序列分析以及有利于人体细胞生长的有利突变候选者的有效搜索方法
Kennosuke Wada,Yoshiko Wada,Toshimichi Ikemura
Kennosuke Wada
We first conducted time-series analysis of mono- and dinucleotide composition for over 10,000 SARS-CoV-2 genomes, as well as over 1500 Zaire ebolavirus genomes, and found clear time-series changes in the compositions on a monthly basis, whi...
Li Jiang,Xiaoyan Wang,Xiaopeng Zhan et al.
Li Jiang et al.
CircRNA (circular RNA) is a kind of closed circular structure of noncoding RNA molecules without 5' hat structure and 3' polyA, mainly located in the cytoplasm or stored in exosomes. It is not affected by RNA exonuclease, so it's stable and...
Splice2Deep: An ensemble of deep convolutional neural networks for improved splice site prediction in genomic DNA [0.03%]
基于深度卷积神经网络的基因组DNA拼接位点预测模型拼接模型
Somayah Albaradei,Arturo Magana-Mora,Maha Thafar et al.
Somayah Albaradei et al.
Background: The accurate identification of the exon/intron boundaries is critical for the correct annotation of genes with multiple exons. Donor and acceptor splice sites (SS) demarcate these boundaries. Therefore, derivi...
Glucose and TNF enhance expression of TNF and IL1B, and histone H3 acetylation and K4/K36 methylation, in juvenile macrophage cells [0.03%]
葡萄糖和TNF通过组蛋白H3乙酰化、甲基化促进幼年巨噬细胞中TNF和IL-1β的表达
Kazue Honma,Chie Machida,Kazuki Mochizuki et al.
Kazue Honma et al.
Hyperglycemia activates innate leukocytes such as monocytes and induces pro-inflammatory cytokine expression, resulting in increased monocyte adhesion to aortic endothelial cells. In this study, we investigated whether high glucose and/or t...
Protective functions of alternative splicing transcripts (CdDHN4- L and CdDHN4- S) of CdDHN4 from bermudagrass under multiple abiotic stresses [0.03%]
百喜草CdDHN4基因两个可变剪切转录本(CdDHN4-L和CdDHN4-S)在多种非生物胁迫下的保护功能研究
Di Zhang,Aimin Lv,Tianchen Yang et al.
Di Zhang et al.
Dehydrins (DHNs) play critical roles in plant adaptation to abiotic stresses. The objective of this study was to characterize DHNs in bermudagrass (Cynodon spp.). CdDHN4 gene was cloned from bermudagrass 'Tifway'. Two CdDHN4 transcripts wer...
Shaimar R González Morales,Chengjing Liu,Heath Blankenship et al.
Shaimar R González Morales et al.
Mouse Ptchd3 (patched domain containing 3) was previously identified as a male germ-cell specific gene. The protein product of this gene has been found on the surface of mouse, rat and human sperm. Since Ptchd3 contains a conserved patched ...
ALCAM (CD166) as a gene expression marker for human mesenchymal stromal cell characterisation [0.03%]
ALCAM(CD166)作为人基质干细胞特征分析的一种基因表达标志物研究
Bas Brinkhof,Bo Zhang,Zhanfeng Cui et al.
Bas Brinkhof et al.
Background: Human mesenchymal stromal cells (MSCs) phenotypically share their positive expression of the International Society for Cell and Gene Therapy (ISCT) markers CD73, CD90 and CD105 with fibroblasts. Fibroblasts ar...
Enhanced immortalization, HUWE1 mutations and other biological drivers of breast invasive carcinoma in Black/African American patients [0.03%]
黑人/非裔美国人乳腺浸润性癌的增强型永生化、HUWE1突变及其他生物学驱动因素
Terrick Andey,Michael M Attah,Nana Adwoa Akwaaba-Reynolds et al.
Terrick Andey et al.
Black/African-American (B/AA) breast cancer patients tend to have more aggressive tumor biology compared to White/Caucasians. In this study, a variety of breast tumor molecular expression profiles of patients derived from the two racial gro...
Interrogation of the cell wall integrity pathway in Aspergillus niger identifies a putative negative regulator of transcription involved in chitin deposition [0.03%]
曲霉细胞壁的完整性途径鉴定出一个可能的负向转录调控因子参与了几丁质沉积
Tim M van Leeuwe,Mark Arentshorst,Peter J Punt et al.
Tim M van Leeuwe et al.
Post-fermentation fungal biomass waste provides a viable source for chitin. Cell wall chitin of filamentous fungi, and in particular its de-N-acetylated derivative chitosan, has a wide range of commercial applications. Although the cell wal...