Efficacy and safety of repetitive transcranial magnetic stimulation on motor function, depression, and cognitive dysfunction in Parkinson's disease: A systematic review and meta-analysis of randomized controlled trials [0.03%]
重复经颅磁刺激对帕金森病运动功能、抑郁和认知障碍的有效性和安全性：系统评价和meta分析
Wenming Lu,Longxiang Yan,Chuangguo Li et al.
Wenming Lu et al.
Background: Parkinson's disease (PD) is a multifactorial neurodegenerative disease with a high prevalence worldwide, leading to motor and non-motor symptoms. Moreover, PD presents a progressive aggravation alongside time,...
Temporal patterns of motor and nonmotor symptom emergence in Parkinson's disease: a cluster analysis [0.03%]
帕金森病运动及非运动症状出现的时间规律：聚类分析
Yoko Sugimura,Toru Baba,Tomoko Totsune et al.
Yoko Sugimura et al.
Background: Parkinson's disease is a heterogeneous disorder characterized by a broad spectrum of motor and nonmotor symptoms. Recent studies suggest that the order of motor and nonmotor symptom development may indicate di...
Epidemiology of Parkinson's disease - Global burden of disease research from 1990 to 2021 and future trend predictions [0.03%]
1990至2021年全球疾病负担研究中的帕金森病流行病学及未来趋势预测
Sen Wang,Yujie Che,Yiqun Lin et al.
Sen Wang et al.
Background: Parkinson's disease (PD), a common neurodegenerative disorder, severely affects patients' quality of life. This study aims to update the assessment of PD's prevalence, incidence, mortality, and disability-adju...
Explore thyself: is it time for metacognition screening in clinical trials? [0.03%]
探索自我：临床试验中是否需要元认知筛查？
Andrew McGarry,Scott Y H Kim,Peggy Auinger et al.
Andrew McGarry et al.
Participant self-report has become increasingly important in the design of clinical trials for Parkinson's Disease (PD), resonating with the general sense that a person's account of their experience should be a prime consideration in evalua...
Alexander Calvano,Dilara Bingoel,Laura Beccaria et al.
Alexander Calvano et al.
We describe a young woman with a novel homozygous PARK7 mutation causing an early-onset and progressive parkinsonism-dystonia syndrome with poor dopaminergic response. Clinical heterogeneity among homozygous mutation carriers emphasises tha...
Validation of the Norwegian version of the Movement Disorder Society-Unified Parkinson's Disease Rating Scale [0.03%]
帕金森病统一评分量表(MDS-UPDRS)挪威版本的验证研究
Guido Alves,Yvonne Stavland Sørenes,Veslemøy Hamre Frantzen et al.
Guido Alves et al.
Introduction: The Movement Disorder Society-revised version of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS) is the gold standard assessment for evaluating Parkinson's disease (PD) symptoms and severity, but a ...
Ananda Carolina Moraes de Falcone,Carina França,Thiago Gonçalves Guimarães et al.
Ananda Carolina Moraes de Falcone et al.
Deep Brain Stimulation (DBS) has revolutionized Parkinson's disease treatment, yet post-operative challenges persist, including reversible programming errors caused by insufficient clinician training. Approximately 40 % of suboptimal outcom...
Confirmation of biallelic VPS11 variants as a cause of complex dystonic syndrome [0.03%]
VPS11双等位基因变异引起复杂扭转痉挛综合征的证据
Arnaud Storck,Marie Thérèse Abiwarde,Gaelle Hardy et al.
Arnaud Storck et al.
•VPS11 is associated with hypomyelinated leukodystrophy affecting children.•A single case of adult-onset generalized dystonia was reported.•We provide the first replication by describing a second case of complex dystonia related to biall...
Emerging neurotechnological approaches to management of sleep disturbances in Parkinson's disease [0.03%]
帕金森病睡眠障碍的新型神经技术管理方法
Mason Dallegge,Sanjana Murthy,Don M Tucker et al.
Mason Dallegge et al.
Among non-motor symptoms of Parkinson's disease (PD), sleep disruption is highly prevalent and may be a target for emerging neurotechnological approaches to treatment. Neuroanatomical and chemical changes in PD significantly impact sleep re...
Differentiating effects of levodopa and subthalamic nucleus deep brain stimulation on motor features in Parkinson disease [0.03%]
左旋多巴和丘脑底核深部电刺激对帕金森病运动功能影响的差异性研究
Tiffanie A Lee,Deepa Ramesh,Mwiza Ushe et al.
Tiffanie A Lee et al.
Introduction: While deep brain stimulation of the subthalamic nucleus (STN DBS) is traditionally used to treat motor fluctuations in Parkinson disease (PD), recent progress in levodopa delivery systems may offer non-invas...