Clinical characteristics of SARS-CoV-2 infection in patients with chronic hepatitis B during interferon antiviral therapy [0.03%]
干扰素抗病毒治疗的慢性乙型肝炎患者感染SARS-CoV-2的临床特征分析
Shiyu Wang,Ziyu Zhang,Xinxin Li et al.
Shiyu Wang et al.
To investigate the clinical characteristics of coronavirus disease 2019 (COVID-19) infection in patients with chronic hepatitis B (CHB) during interferon antiviral therapy and to explore the correlation between interferon use and COVID-19 i...
TempSnap-Trace: A temporal snapshot-based framework for haplotype network tracing [0.03%]
基于时间快照的基因型网络追踪框架-tempSnap-Trace
Jiajun Liu,Decheng Li,Yixue Li et al.
Jiajun Liu et al.
To address the challenge of tracking large-scale viral evolutionary history, this study introduces TempSnap-Trace, a novel computational framework designed for this purpose. The methodology processes genomic data to generate variant-feature...
Rui Wang,Jianping Huang,Xinbo Lian et al.
Rui Wang et al.
The explosive growth during the early stages and the sustained transmission in the later phases of the coronavirus disease 2019 (COVID-19) pandemic may be closely linked to superspreading events (SSEs), yet in-depth research into their spec...
Large language models for biological sequence analysis in infectious disease research [0.03%]
大型语言模型在传染病研究中的生物序列分析中的应用
Junyu Luo,Xiyang Cai,Yixue Li
Junyu Luo
Large language models (LLMs) have emerged as transformative tools in infectious disease research, offering unprecedented capabilities in analyzing biological sequences. This review summarizes three primary types of biological LLMs, includin...
Interactions between zoonotic pathogens and infectious disease spread: Why understanding mechanisms and modelling matters more than ever [0.03%]
人畜共患病病原体与传染病传播之间的相互作用：为什么了解机制和建模比以往任何时候都重要
Naizhe Li,Sunxiao Ruan,Huaiyu Tian
Naizhe Li
Interactions among zoonotic pathogens play a critical role in shaping disease transmission, severity, and public health responses. However, the mechanisms and population-level consequences of these interactions remain underexplored in curre...
Application progress and biosafety challenges of gene editing and synthetic biotechnology in diagnosis, treatment and prevention of infectious diseases [0.03%]
基因编辑和合成生物技术在传染病诊治和预防中的应用进展与生物安全挑战
Zixuan Gao,Yuanjiao Gao,Shuojie Wang et al.
Zixuan Gao et al.
Global infectious disease prevention faces escalating challenges due to the continual emergence of novel pathogens and rapid viral mutations. Synthetic biology has revolutionized this field by enabling precise diagnostics, innovative vaccin...
Global trends, age-period-cohort analysis, and future projections of diarrhea burden: Findings from the Global Burden of Disease Study 2021 [0.03%]
全球腹泻疾病负担的全球趋势、年龄-时期-世代分析及未来预测：全球疾病负担研究（2021年）的结果
Mengjiao Xie,Yang Song,Jing Tao et al.
Mengjiao Xie et al.
Diarrhea is currently a prominent global public health issue. This study evaluated recent trends in the global burden of diarrhea and projected future changes over the next decade. Using the diarrhea data from the global burden of disease (...
Metagenomics research on the gut microbiota of the Marmota himalayana of the Sanjiangyuan National Nature Reserve in Qinghai Province, China [0.03%]
青藏高原三江源国家自然保护区喜马拉雅旱獭肠道微生物组的元基因组学研究
Ying Ma,Ziyan Li,Pengbo Liu et al.
Ying Ma et al.
With the improvement of transportation and the rise of tourism on the Qinghai-Xizang Plateau, the scope of human activities has continuously expanded, increasing opportunities for contact with wildlife, also exacerbating the outbreak rate o...
Beyond evolution: De novo designed protein toolkit rewriting the rules of synthetic biology [0.03%]
超越进化：从头设计的蛋白质工具包重写合成生物学规则
Guohao Zhang,Chuanyang Liu,Wenying Li et al.
Guohao Zhang et al.
Artificial intelligence (AI)-driven de novo protein design is revolutionizing synthetic biology by facilitating the first-principle rational engineering of protein-based functional modules unbound by known structural templates and evolution...
Evaluating viral inactivation in the liquid waste stream from a viral total nucleic acid extraction kit for safe disposal [0.03%]
评估病毒总核酸提取试剂盒液废中病毒灭活情况以实现安全排放
Charles Gan,Melissa Pitton,Lea Caduff et al.
Charles Gan et al.
Safe laboratory processing requires mitigating risks from the release of pathogens into the environment through generated waste streams. This study evaluated the inactivation kinetics of bacteriophage MS2 as a surrogate for infectious virus...