AI-assisted identification of a novel Orthopoxvirus inhibitor targeting F13 [0.03%]
基于人工智能的新型正痘病毒F13靶向抑制剂鉴定
Junwen Luan,Annan Ming,Wenbo Zhao et al.
Junwen Luan et al.
Treatment of mpox virus (MPXV) is crucial for public health. However, research into drugs for MPXV has fallen behind, particularly in anticipation of sudden outbreaks. This study aimed to identify new inhibitors of Orthopoxvirus using artif...
Computational optimization of a pan-coronavirus fusion inhibitory peptide targeting spike's heptapeptide repeat region [0.03%]
计算优化针对刺突蛋白七肽重复区域的广谱冠状病毒融合抑制多肽
Peixiang Gao,Shuo Liu,Xiaojing Chi et al.
Peixiang Gao et al.
In the past two decades, highly pathogenic coronaviruses (CoVs), such as severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and severe acute respiratory syndrome coronavirus 2 ...
Exploring enterovirus pathogenesis and cancer therapy potential through reverse genetics [0.03%]
通过反向遗传学探索肠道病毒的致病机制及其癌症治疗潜力
Shijin Wang,Qing Yu,Junfeng Zhou et al.
Shijin Wang et al.
Over the past decades, oncolytic viruses have emerged as prominent therapeutic agents with significant potential for anticancer treatment. Enteroviruses (EVs) have garnered particular attention due to their specific tropism for various type...
Jiashu Li,Tianyuan Jia,Liang Yang
Jiashu Li
Antibiotic-resistant bacterial pathogens pose substantial biosafety and health hazards, leading to millions of deaths each year. The evolution of bacterial virulence factors is mainly propelled by horizontal gene transfer (HGT). In addition...
Integrative single-cell and metagenomic analysis dissects SARS-CoV-2 shedding modes in human respiratory tract [0.03%]
整合单细胞和元基因组分析解剖了人类呼吸道中SARS-CoV-2的排出模式
Xiangxing Jin,Lili Ren,Xianwen Ren et al.
Xiangxing Jin et al.
It is crucial to understand how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sheds in human respiratory tract, but this question remains elusive due to technical limitations. In this study, we integrated published human meta...
Sustained circulation of Aedes albopictus-derived novel almendraviruses in the urban parks [0.03%]
城市公园中源自白纹伊蚊的新颖almendravirus的持续传播
Xi Zhang,Chengyu Liu,Yang Han et al.
Xi Zhang et al.
The Rhabdoviridae family comprises a diverse range of negative-sense single-stranded ribonucleic acid (RNA) viruses, including significant human and mammalian viruses transmitted by various arthropod species. Herein, using Aedes albopictus ...
Advances and perspectives for animal models of chikungunya virus infection [0.03%]
chickungunya病毒感染动物模型的研究进展与前景
Meng Zou,Zhihui Zheng,Wei Wang et al.
Meng Zou et al.
With the global warming, the expansion of transportation networks, a tremendous increase in international travel and exchange, and the ongoing evolution of viruses, chikungunya virus (CHIKV) has spread beyond its African origins and achieve...
Teng Zhao,Teng Chen,Jie Zhang et al.
Teng Zhao et al.
Chikungunya virus (CHIKV), a mosquito-borne alphavirus first identified in Tanzania in 1952, has expanded to more than 100 countries posing increasing global health risks. The 2025 epidemic in Réunion Island and local transmission in Fosha...
An explainable artificial intelligence framework reveals mutations associated with drug resistance in Mycobacterium tuberculosis [0.03%]
一种解释性的人工智能框架揭示了与结核分支杆菌药物耐药性相关的突变
Hui Cen,Peng Zhang,Yunchao Ling et al.
Hui Cen et al.
Understanding the mechanisms of drug resistance in Mycobacterium tuberculosis (MTB) is essential for the rapid detection of resistance and for guiding effective treatment, ultimately contributing to reducing the global burden of tuberculosi...
Harnessing a high-quality Salmonella genome catalog to combat antimicrobial resistance and inform outbreak responses [0.03%]
利用高质量的大肠杆菌基因组目录对抗抗生素抗性及应对疫情爆发提供信息
Beiwen Zheng,Yi Liu,Yonghong Xiao
Beiwen Zheng
•A century-scale analysis of 208,000 + Salmonella genomes reveals accelerating global antimicrobial resistance (AMR).•Multidrug-resistant Salmonella outbreaks are rising worldwide, endangering food safety and public health systems.•Fluor...