John B Haanen
John B Haanen
High multiplex analysis of the immune microenvironment in bone marrow trephine samples using GeoMX™ digital spatial profiling [0.03%]
采用GeoMX数字空间分析技术对骨髓活检样本免疫微环境进行高通量分析
R M Koldej,D S Ritchie
R M Koldej
Background: To date, studies into the bone marrow (BM) immune microenvironment have been limited due to reliance on the analysis of BM aspirates in which the microenvironmental context is lost. GeoMX™ digital spatial pro...
E A Lim,C G Drake,A Mintz
E A Lim
Immunotherapy has changed the treatment landscape for many cancers; however, not all patients treated have a favorable response and others can develop immune-related adverse events. A method to predict the treatment response to immunotherap...
Computational cancer neoantigen prediction: current status and recent advances [0.03%]
计算性癌症新抗原预测：现状与近期进展
G Fotakis,Z Trajanoski,D Rieder
G Fotakis
Over the last few decades, immunotherapy has shown significant therapeutic efficacy in a broad range of cancer types. Antitumor immune responses are contingent on the recognition of tumor-specific antigens, which are termed neoantigens. Tum...
L M Roelofsen,P Kaptein,D S Thommen
L M Roelofsen
Immune checkpoint blockade (ICB) unleashes immune cells to attack tumors, thereby inducing durable clinical responses in many cancer types. The number of patients responding to ICB is modest, however, and combination treatments are likely n...
L Chocarro,E Blanco,H Arasanz et al.
L Chocarro et al.
Lymphocyte-activated gene 3 (LAG-3) is a cell surface inhibitory receptor and a key regulator of immune homeostasis with multiple biological activities related to T-cell functions. LAG-3 is considered a next-generation immune checkpoint of ...
Trieu My Van,Christian U Blank
Trieu My Van
Characterization of spatial protein expression for multiple targets from a single tissue is difficult to perform, especially due to the limitations of multiplex immunohistochemistry and tissue heterogeneity. Therefore, a new technology is r...
John B Haanen
John B Haanen
Oliver Nussbaumer,Michael Koslowski
Oliver Nussbaumer
The recent successes of chimeric antigen receptor T cells in the treatment of hematological malignancies have clearly led to an explosion in the field of adoptive cell therapy for cancer. Current efforts are focused on the translation of th...
Gene editing: Towards the third generation of adoptive T-cell transfer therapies [0.03%]
基因编辑：朝向第三代过继T细胞治疗技术发展
Cristina Puig-Saus,Antoni Ribas
Cristina Puig-Saus
First-generation adoptive T-cell transfer (ACT) administering tumor-infiltrating lymphocytes (TILs), and second-generation ACT using autologous T cells genetically modified to express tumor-specific T-cell receptors (TCRs) or chimeric antig...