Histiocytic Sarcoma Treated with Pembrolizumab: A Case Report and Literature Review [0.03%]
接受派姆单抗治疗的组织细胞肉瘤：一个病例报道及文献回顾
Daniel Huff,Shannon Fortin Ensign,Margaret S Ryan et al.
Daniel Huff et al.
Histiocytic sarcoma (HS) is a rare hematologic malignancy that has historically been treated with lymphoma-based regimens with a median survival of 6 months. We describe a case of a 51-year-old woman who presented with acute back pain and c...
Multidisciplinary Care of a Large Brain Metastasis in a Patient with Hormone-Receptor-Positive Breast Cancer with Ataxia-Telangiectasia Mutation [0.03%]
带有ataxiatelangiectasia突变的激素受体阳性乳腺癌患者的大脑转移瘤多学科治疗
Anca Chelariu-Raicu,Sarina A Piha-Paul,Mariana Chavez-MacGregor et al.
Anca Chelariu-Raicu et al.
Poly (adenosine diphosphate-ribose) polymerase inhibitors (PARP)i are emerging as standard oncology treatments in various tumor types. The indications will expand as PARPi are being investigated in various breast cancer subtypes. Currently,...
Targeted and Immunotherapy Approaches in HER2-Positive Gastric and Gastroesophageal Junction Adenocarcinoma: A New Era [0.03%]
HER2阳性胃及胃食管交界腺癌的靶向和免疫治疗：新时代来临
Maluki Radford,Hassan Abushukair,Stijn Hentzen et al.
Maluki Radford et al.
HER2-targeted therapy with the HER2 monoclonal antibody trastuzumab has achieved impressive outcomes in the first-line settings of patients with advanced gastric and gastroesophageal junction (GEJ) adenocarcinoma overexpressing HER2. Howeve...
Optimizing the Treatment for Advanced Non-Small-Cell Lung Cancer with Mutated Epidermal Growth Factor Receptor in Low-Income Countries: A Review [0.03%]
低收入国家表皮生长因子受体突变型晚期非小细胞肺癌治疗优化策略的评估：综述文章
Mousa Alali,Maher Saifo
Mousa Alali
Introduction: Osimertinib is the treatment of choice for epidermal growth factor receptor (EGFR)-mutated advanced non-small-cell lung cancer (NSCLC). Because of its high price, many low-income countries, such as Syria, ca...
Autoimmune HLA Alleles and Neoepitope Presentation Predict Post-Allogenic Transplant Relapse [0.03%]
自身免疫性人类白细胞抗原等位基因和新表位的呈现预测异体移植后的复发风险
Andrea Castro,Aaron M Goodman,Zachary Rane et al.
Andrea Castro et al.
Introduction: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) can cure patients with high-risk myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). However, many patients relapse or develop deb...
Treatment of Stage IV Non-Small Cell Lung Cancer with Pembrolizumab in Combination with Platinum-Based Doublet Chemotherapy in Vietnam [0.03%]
帕博利珠单抗联合含铂化疗治疗越南IV期非小细胞肺癌患者的疗效
Khanh Toan Nguyen,To Ta Van
Khanh Toan Nguyen
Introduction: Lung cancer has been one of the most prevalent cancers worldwide in recent decades. According to the findings of the KEYNOTE-407 (2018) study on patients with stage IV squamous cell lung cancer, the combinat...
Ian J Robertson,Timothy A Gregory,Steven G Waguespack et al.
Ian J Robertson et al.
Pituitary carcinoma (PC) is a rare, aggressive malignancy that comprises 0.1-0.2% of all pituitary tumors. PC is defined anatomically as a pituitary tumor that metastasizes outside the primary intrasellar location as noncontiguous lesions i...
Translational Studies Using the MALT1 Inhibitor (S)-Mepazine to Induce Treg Fragility and Potentiate Immune Checkpoint Therapy in Cancer [0.03%]
利用(S)-Mepazine抑制剂进行转化研究以诱导Treg脆弱性并增强癌症免疫检查点治疗效力
Mauro Di Pilato,Yun Gao,Yi Sun et al.
Mauro Di Pilato et al.
Introduction: Regulatory T cells (Tregs) play a critical role in the maintenance of immune homeostasis but also protect tumors from immune-mediated growth control or rejection and pose a significant barrier to effective i...
Mirella Nardo,Deniz Can Guven,Aysun Senturk Yikilmaz et al.
Mirella Nardo et al.