Management of Hepatitis B Virus and Hepatitis C Virus Infections in Patients with Cancer Receiving Immune Checkpoint Inhibitors [0.03%]
免疫检查点抑制剂治疗肿瘤患者合并乙型和丙型肝炎病毒感染的管理指南
Khalis Mustafayev,Vincent Mallet,Harrys A Torres
Khalis Mustafayev
Background: Patients with cancer with hepatitis B virus (HBV) or hepatitis C virus (HCV) infection are excluded from many cancer clinical trials of immune checkpoint inhibitors (ICIs). Therefore, data are limited regardin...
Images in Immunotherapy and Precision Oncology: A Case Report of Neurofibromatosis-1 [0.03%]
免疫疗法和精准肿瘤学中的影像学：NF-1病例报告
Anagha Deshpande,Javier Munoz,Vrushali Dabak et al.
Anagha Deshpande et al.
Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic disorder that primarily causes the growth of tumors along nerves. Additionally, the germline mutations involved in NF1 predispose patients to develop further malignancies. The ...
Immune Checkpoint Inhibitors and Glioblastoma: A Review on Current State and Future Directions [0.03%]
免疫检查点抑制剂与胶质母细胞瘤：现状和未来方向的综述
Merve Hazal Ser,Mason J Webb,Ugur Sener et al.
Merve Hazal Ser et al.
Glioblastoma (GBM) is the most prevalent malignant tumor of the central nervous system. The prognosis of GBM is grim, with a median overall survival of 14.6 months and only 6.9% of patients surviving 5 years after the initial diagnosis. Des...
Keeping an Eye Out for Immunotherapy Toxicity: A Case of Unilateral Ptosis Caused by Ipilimumab/Nivolumab Therapy [0.03%]
警惕免疫治疗毒性反应-一例伊匹单抗/纳武单抗治疗诱发的单侧眼睑下垂病例报告
Khalid Jazieh,Lisa Kottschade,Anastasios Dimou
Khalid Jazieh
Despite ocular adverse events from immune checkpoint inhibitors being uncommon, they are still important complications to be aware of. We present the case of metastatic melanoma on ipilimumab/nivolumab in a patient who developed immunothera...
T cell Immunoglobulin and Mucin Domain Containing Protein 3 (TIM-3) Inhibitors in Oncology Clinical Trials: A Review [0.03%]
肿瘤临床试验中的T细胞免疫球蛋白和黏蛋白结构域含有蛋白3(TIM-3)抑制剂：综述
Benjamin Duong,Pratyush Banskota,Gerald S Falchook
Benjamin Duong
T cell immunoglobulin and mucin domain containing protein 3 (TIM-3) is a receptor found on a multitude of immune cells and is commonly overexpressed in patients with cancer. Due to its selective expression in immune cells and its preliminar...
Impact of COVID-19 on Management and Outcomes of Oncology Patients: Results of MENA COVID-19 and Cancer Registry (MCCR) [0.03%]
新型冠状病毒肺炎疫情对肿瘤患者管理及预后影响的研究——来自中东和北非地区新冠肺炎与癌症注册协会(MCCR)的数据报告
Abdul-Rahman Jazieh,Adda Bounedjar,Hikmat Abdel-Razeq et al.
Abdul-Rahman Jazieh et al.
Introduction: Despite extensive studies of the impact of COVID-19 on patients with cancer, there is a dearth of information from the Middle East and North Africa (MENA) region. Our study aimed to report pertinent MENA COV...
Phase Ib/II Study of Lacnotuzumab in Combination with Spartalizumab in Patients with Advanced Malignancies [0.03%]
拉科妥珠单抗联合斯帕托利单抗治疗晚期恶性肿瘤患者的Ⅰb/Ⅱ期研究
Jibran Ahmed,Bettzy Stephen,Yali Yang et al.
Jibran Ahmed et al.
Introduction: Blocking the colony-stimulating factor 1 (CSF-1) signal on tumor-associated macrophages can lead to an upregulation of checkpoint molecules, such as programmed cell death ligand 1 (PD-L1), thus causing resis...
Proton Craniospinal Irradiation with Immunotherapy in Two Patients with Leptomeningeal Disease from Melanoma [0.03%]
两位黑素瘤引起软脑膜疾病的患者在免疫治疗下进行质子全颅脊髓照射治疗
Ugur Sener,Mason Webb,William G Breen et al.
Ugur Sener et al.
Introduction: Proton craniospinal irradiation (pCSI) is a treatment option for leptomeningeal disease (LMD), which permits whole neuroaxis treatment while minimizing toxicity. Despite this, patients inevitably experience ...
Oral Toxicities Associated with Immune Checkpoint Inhibitors: Meta-Analyses of Clinical Trials [0.03%]
免疫检查点抑制剂相关的口腔毒性：临床试验的荟萃分析
Akanksha Srivastava,Graciela M Nogueras-Gonzalez,Yimin Geng et al.
Akanksha Srivastava et al.
Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment; however, their oral toxicity profile is not well elucidated. This review aimed to investigate the prevalence of oral toxicities including xerostomia, mucositis/stomat...
Nouran Muhammed Roby,Mohamed Hassan,Mohamed A Aboelkasem et al.
Nouran Muhammed Roby et al.
Introduction: Adaptive radiotherapy (ART) is an essential approach to account for anatomical and biological uncertainties. Adaptive radiotherapy is, however, time-consuming, and it is unclear which patients are eligible o...