Use of Immunoglobulin Replacement Therapy in Clinical Practice: A Review [0.03%]
免疫球蛋白替代疗法的临床应用：综述性论文
Jibran Ahmed,Yeonjoo Choi,Taeyeong Ko et al.
Jibran Ahmed et al.
Immunoglobulins (Igs) are produced by B lymphocytes and play a key role in humoral immunity. Igs are classified into five isotypes (IgG, IgA, IgM, IgE, and IgD). Their primary function is to recognize and bind to foreign antigens. When Igs ...
Usefulness of Comprehensive Genomic Profiling in Clinical Decision-Making in Oncology: A Systematic Review [0.03%]
全面基因组分析在肿瘤临床决策中的应用价值：系统性综述
Sewanti Limaye,Jayesh Deshmukh,Nitesh Rohatagi et al.
Sewanti Limaye et al.
Biologic factors limiting responsiveness to matched targeted therapies include genomic heterogeneity and complexity. Advanced tumors with unique molecular profiles can be studied by comprehensive genomic profiling (CGP) and enhance patient ...
Cyclin Dependent Kinase 2 (CDK2) Inhibitors in Oncology Clinical Trials: A Review [0.03%]
肿瘤临床试验中 cyclin依赖性激酶2(CDK2)抑制剂的进展及思考—— review
Isabelle House,Mari Valore-Caplan,Elijah Maris et al.
Isabelle House et al.
Cyclin dependent kinase 2 (CDK2) is responsible for enforcing progression through the G1-S phase transition. Mutations and alterations in the CDK2 signaling pathway are associated with various cancers, most commonly breast, ovarian, prostat...
Real-World Outcomes in Patients with Advanced Penile Squamous Cell Carcinoma Receiving Immune Checkpoint Inhibitors: A Single Institution Experience [0.03%]
免疫检查点抑制剂治疗晚期阴茎鳞状细胞癌患者的真实世界疗效：单一机构经验
Tony Z Zhuang,Subir Goyal,Katherine B Case et al.
Tony Z Zhuang et al.
Introduction: Advanced penile squamous cell carcinoma (pSCC) is a rare and aggressive malignancy with a poor prognosis and an unmet need for biomarkers. We performed a retrospective evaluation of real-world efficacy, safe...
A Rare But Fatal Toxicity: Immune Checkpoint Inhibitor-Related Acquired Thrombotic Thrombocytopenic Purpura [0.03%]
一种罕见但具有威胁生命的毒性：免疫检查点抑制剂相关获得性血栓性血小板减少性紫癜
Aysun Senturk Yikilmaz,Cristhiam M Rojas Hernandez
Aysun Senturk Yikilmaz
Thrombotic thrombocytopenic purpura (TTP) is characterized by thrombotic microangiopathy resulting from decreased activation of the von Willebrand factor-cleaving protease (ADAMTS13). TTP can cause organ damage and is often fatal if the app...
Durable Remission After Targeted Therapy in BRAF V600E- Mutant Metastatic Colorectal Cancer: Case Report [0.03%]
BRAF V600E突变转移性结直肠癌经靶向治疗后获得持续缓解：病例报告
Daniel A Fox,Deepak Bhamidipati,Scott Kopetz et al.
Daniel A Fox et al.
BRAF mutation leads to constitutive activation of the MAPK pathway and is associated with the immune-activating molecular subtype of colorectal cancer. Targeted therapy for BRAF V600E-mutant metastatic colorectal cancer (CRC) has significan...
Expert Clinical Management of Inflammatory Immune-Related Arthritis in Patients with Cancer Receiving Immune Checkpoint Inhibitors [0.03%]
癌症患者接受免疫检查点抑制剂治疗时发生炎性自身免疫相关关节炎的专家管理意见书
Sebastian Bruera,Mar Riveiro-Barciela,Alexa Meara et al.
Sebastian Bruera et al.
Introduction: Treatment guidelines for immune-related inflammatory arthritis (irAE-IA) in patients with cancer receiving immune checkpoint inhibitors (ICIs) are vague with respect to the use of specific agents. Patients a...
Oncology Clinical Trials Targeting Members of the Cadherin Superfamily: A Review [0.03%]
钙黏着蛋白超家族成员抗肿瘤药物临床试验进展及其机制研究
Jacob Keeling,Gerald Falchook
Jacob Keeling
The cadherin superfamily of proteins is critical for cell-cell interactions and demonstrates tissue-specific expression profiles. In cancers, disruption of cell-cell adhesion is frequently associated with oncogenesis and metastasis. As such...
Diaphragmatic Myopathy Associated with Dual Immune Checkpoint Inhibitors in a Patient with Renal Cell Carcinoma [0.03%]
肾细胞癌患者接受免疫检查点抑制剂治疗后出现膈肌肌病一例报告
Jeremy R Walder,Saadia A Faiz,Sudhakar Tummala et al.
Jeremy R Walder et al.
Immune-related adverse events (irAEs) have become increasingly prevalent with immune checkpoint inhibitor (ICI) cancer treatment. We present a 79-year-old man with metastatic renal cell carcinoma who developed shortness of breath and hyperc...
A Phase Ib Study of Selinexor in Combination with Pembrolizumab in Patients with Metastatic Melanoma [0.03%]
塞利尼索联合派姆单抗治疗转移性黑色素瘤Ib期试验
Mohamed A Gouda,Bettzy Stephen,Yanyan Tian et al.
Mohamed A Gouda et al.
Immune checkpoint inhibitors (ICIs) have substantially advanced the treatment of patients with malignant melanoma. However, improving therapeutic efficacy requires identifying drug combinations that elicit durable responses without inducing...