Brain-predicted age difference mediates the association between PROMIS sleep impairment, and self-reported pain measure in persons with knee pain [0.03%]
基于大脑预测的年龄差距介导了膝关节疼痛患者PROMIS睡眠障碍与自陈式疼痛测量之间的关系
Soamy Montesino-Goicolea,Pedro Valdes-Hernandez,Chavier Laffitte Nodarse et al.
Soamy Montesino-Goicolea et al.
Knee pain, the most common cause of musculoskeletal pain (MSK), constitutes a severe public health burden. Its neurobiological causes, however, remain poorly understood. Among many possible causes, it has been proposed that sleep problems c...
K G Akbulut,A Keskin-Aktan,S A Abgarmi et al.
K G Akbulut et al.
Background: Though the exact mechanisms regarding brain aging and its relation to neurodegenerative disorders are not precise, oxidative stress, the key regulators of apoptosis and autophagy, such as bcl-2 and beclin 1, s...
Short-term blood pressure variability is inversely related to regional amplitude of low frequency fluctuations in older and younger adults [0.03%]
短期血压变异性与老年人和年轻人大脑低频振荡幅度呈负相关关系
Isabel J Sible,Hyun Joo Yoo,Jungwon Min et al.
Isabel J Sible et al.
Blood pressure variability (BPV), independent of mean blood pressure levels, is associated with cerebrovascular disease burden on MRI and postmortem evaluation. However, less is known about relationships with markers of cerebrovascular dysf...
No moderating influence of education on the association between changes in hippocampus volume and memory performance in aging [0.03%]
教育对衰老过程中海马体积变化和记忆力表现之间关系的调停作用有限
Martin Lövdén,Amos Pagin,David Bartrés-Faz et al.
Martin Lövdén et al.
Contemporary accounts of factors that may modify the risk for age-related neurocognitive disorders highlight education and its contribution to a cognitive reserve. By this view, individuals with higher educational attainment should show wea...
Upregulation of endocytic protein expression in the Alzheimer's disease male human brain [0.03%]
阿尔茨海默病男性人脑中内吞蛋白表达的上调
Mouhamed Alsaqati,Rhian S Thomas,Emma J Kidd
Mouhamed Alsaqati
Amyloid-beta (Aβ) is produced from amyloid precursor protein (APP) primarily after APP is internalised by endocytosis and clathrin-mediated endocytic processes are altered in Alzheimer's disease (AD). There is also evidence that cholestero...
Alteration of brain function and systemic inflammatory tone in older adults by decreasing the dietary palmitic acid intake [0.03%]
通过降低饮食中的棕榈酸摄入量改变老年人大脑功能和全身炎症状态
Julie A Dumas,Janice Y Bunn,Michael A LaMantia et al.
Julie A Dumas et al.
Prior studies in younger adults showed that reducing the normally high intake of the saturated fatty acid, palmitic acid (PA), in the North American diet by replacing it with the monounsaturated fatty acid, oleic acid (OA), decreased blood ...
Longitudinal change-change associations of cognition with cortical thickness and surface area [0.03%]
认知与皮层厚度和表面积的纵向变化关系
Lars Nyberg,Micael Andersson,Anders Lundquist
Lars Nyberg
Age-related changes in cortical volumes are well established but relatively few studies probed its constituents, surface area (SA) and thickness (TH). Here we analyzed 10-year, 3-waves longitudinal data from a large sample of healthy indivi...
Sadashiva K Pai
Sadashiva K Pai
Dopamine D1-signaling modulates maintenance of functional network segregation in aging [0.03%]
多巴胺D1信号传导调节老化过程中功能网络分离的维持
Robin Pedersen,Jarkko Johansson,Alireza Salami
Robin Pedersen
Past research has shown that as individuals age, there are decreases in within-network connectivity and increases in between-network connectivity, a pattern known as functional dedifferentiation. While the mechanisms behind reduced network ...
Regional serotonin terminal density in aging human brain: A [11C]DASB PET study [0.03%]
人脑衰老的区域型五羟色胺能末梢密度降低：基于[11C]DASB PET影像的研究
Prabesh Kanel,Robert A Koeppe,Vikas Kotagal et al.
Prabesh Kanel et al.
There are conflicting results regarding regional age-related changes in serotonin terminal density in human brain. Some imaging studies suggest age-related declines in serotoninergic terminals and perikarya. Other human imaging studies and ...