Age-related decline in social interaction is associated with decreased c-Fos induction in select brain regions independent of oxytocin receptor expression profiles [0.03%]
社交互动随年龄增长而下降与选定脑区c-Fos的诱导减少有关，这独立于催产素受体表达谱的变化
J Russell Ravenel,Amy E Perkins,Angela Tomczik et al.
J Russell Ravenel et al.
Social behavior decreases with aging, and we have previously found a substantial decline in social investigative behavior of old female rats. In this study we examined the neural activation pattern (c-Fos mRNA) of young (3 month) and old (1...
Age-related differences in structural and resting-state functional brain network organization across the adult lifespan: A cross-sectional study [0.03%]
成人生命周期中结构性及休息状态功能性大脑网络组织的年龄差异性：一项横断面研究
Maedeh Khalilian,Monica N Toba,Martine Roussel et al.
Maedeh Khalilian et al.
We investigated age-related trends in the topology and hierarchical organization of brain structural and functional networks using diffusion-weighted imaging and resting-state fMRI data from a large cohort of healthy aging adults. At the cr...
Aging changes the expression of adenosine receptors, insulin-like growth factor 1 (IGF1), and hypoxia-inducible factor 1α (HIF1α) in hypothalamic astrocyte cultures [0.03%]
衰老改变下丘脑星形胶质细胞培养物中腺苷受体，胰岛素样生长因子1（IGF1）和缺氧诱导因子1α（HIF1α）的表达
Camila Leite Santos,Larissa Daniele Bobermin,André Quincozes-Santos
Camila Leite Santos
The aging process induces neurochemical alterations in different brain regions, including hypothalamus. This pivotal area of the central nervous system (CNS) is crucial for detection and integration of nutritional and hormonal signals from ...
Grey-matter structure in cortical and limbic regions correlates with general cognitive ability in old age [0.03%]
老人大脑皮层和边缘区域的灰质结构与一般认知能力有关
Ylva Köhncke,Simone Kühn,Sandra Düzel et al.
Ylva Köhncke et al.
According to the maintenance hypothesis (Nyberg et al., 2012), structural integrity of the brain's grey matter helps to preserve cognitive functioning into old age. A corollary of this hypothesis that can be tested in cross-sectional data i...
EngAge - A metacognitive intervention to supplement working memory training: A feasibility study in older adults [0.03%]
针对老年人的一项可行性研究：EngAge方案——一种补充工作记忆训练的元认知干预措施
Susanne M Jaeggi,Alexandria N Weaver,Elena Carbone et al.
Susanne M Jaeggi et al.
Working Memory (WM) training has shown promise in supporting cognitive functioning in older adult populations, but effects that generalize beyond the trained task have been inconsistent. Targeting cognitive processes in isolation might be a...
Integrative Precision Medicine for Dementia and Alzheimer's Diseases in Africa [0.03%]
面向非洲的痴呆与阿尔茨海默病整合型精准医学
Abdullahi Tunde Aborode,Nike Jesutofunmi Idowu,Samuel Tundealao et al.
Abdullahi Tunde Aborode et al.
Brain apolipoprotein E levels in mice challenged by a Western diet increase in an allele-dependent manner [0.03%]
由西方饮食引发的小鼠脑源性载脂蛋白E以基因型依赖的方式增加
Braison Liemisa,Samantha F Newbury,Mariah J Novy et al.
Braison Liemisa et al.
Human apolipoprotein E (APOE) is the greatest determinant of genetic risk for memory deficits and Alzheimer's disease (AD). While APOE4 drives memory loss and high AD risk, APOE2 leads to healthy brain aging and reduced AD risk compared to ...
Urine-derived cells from the aged donor for the 2D/3D modeling of neural cells via iPSCs [0.03%]
基于尿源老化细胞通过诱导多能干细胞进行神经细胞二维和三维建模的研究
Sopak Supakul,Yuki Hatakeyama,Nicolas Leventoux et al.
Sopak Supakul et al.
Human neural cell models derived from induced pluripotent stem cells (iPSCs) have been widely accepted to model various neurodegenerative diseases such as Alzheimer's disease (AD) in vitro. Although the most common sources of iPSCs are fibr...
Lars Nyberg,Erika J Laukka,Martin Lövdén
Lars Nyberg
Overcoming hurdles: Enhancing post-mortem capabilities for neurological investigations in Africa [0.03%]
克服障碍：增强非洲神经学调查的尸检能力
Abdullahi Tunde Aborode,Ayah Karra-Aly,Seto Charles Ogunleye et al.
Abdullahi Tunde Aborode et al.