No sex differences in the association between regional brain structure abnormalities and cognitive functioning in a geriatric memory clinic population [0.03%]
老年人记忆门诊就诊人群中脑区结构异常与认知功能障碍关联的性别差异研究
A Lamé,E G Thomas,S A J van de Schraaf et al.
A Lamé et al.
Differences between men and women in cognitive impairment and neurodegeneration are not yet well understood. Although sex differences in brain structure abnormalities, including white matter hyperintensities (WMH) and grey matter (GM) atrop...
Selenium deficiency negatively affects survival and integrity of human hippocampal progenitor cells [0.03%]
硒缺乏对人类海马神经前体细胞的存活和完整性产生负面影响
Sahand Farmand,Emaan Ahmed,Hadisa Azizi Zawar et al.
Sahand Farmand et al.
Selenium has been shown to be a key regulatory element in the health, survival and proliferation of neural stem and progenitor cells, with various studies underlining its anti-aging properties. However, most of this knowledge is derived fro...
Hirokazu Tanabe,Sumihiro Maeda,Etsuko Sano et al.
Hirokazu Tanabe et al.
Abnormal accumulation of tau proteins in the brain is a hallmark of neurodegenerative diseases such as Alzheimer's disease and is closely linked with neuronal cell death. Tau accumulation is a prominent therapeutic target for Alzheimer's di...
Effects of global Ripk2 genetic deficiency in aged mice following experimental ischemic stroke [0.03%]
全球敲除Ripk2基因对年老小鼠缺血性脑卒中的影响
John Aaron Howell,Jonathan Larochelle,Rachel E Gunraj et al.
John Aaron Howell et al.
Besides the loss of blood and oxygen reaching the ischemic tissue, many secondary effects of ischemic stroke can cause additional tissue damage, including inflammation, oxidative stress, and proteomic disturbances. Receptor-interacting seri...
TOMM40 may mediate GFAP, neurofilament light Protein, pTau181, and brain morphometry in aging [0.03%]
TOMM40可能介导GFAP、神经丝轻链蛋白、pTau181和脑形态学在衰老中的作用
Robyn A Honea,Heather Wilkins,Suzanne L Hunt et al.
Robyn A Honea et al.
A growing amount of data has implicated the TOMM40 gene in the risk for Alzheimer's disease (AD), neurodegeneration, and accelerated aging. No studies have investigated the relationship of TOMM40 rs2075650 ('650) on the structural complexit...
Parnika P Saxena,Adam Turnbull,Daniel Kim et al.
Parnika P Saxena et al.
Affective symptoms (i.e., depression, anxiety, and apathy) are the most prevalent subsyndrome of neuropsychiatric symptoms (NPS) in preclinical dementia, such as amnestic mild cognitive impairment (aMCI), and remain a challenge to understan...
Sleep discrepancy and brain glucose metabolism in community-dwelling older adults [0.03%]
社区老年人睡眠差异与大脑葡萄糖代谢的关系
Nadia Soh,Michael Weinborn,James D Doecke et al.
Nadia Soh et al.
Sleep discrepancy (negative discrepancy reflects worse self-reported sleep than objective measures, such as actigraphy, and positive discrepancy the opposite) has been linked to adverse health outcomes. This study is first to investigate th...
Deependra Kumar
Deependra Kumar
Cognitive and gray matter volume predictors of learning across two types of casual video games in older Adults: Action vs Strategy [0.03%]
认知和灰质体积预测老年人在两种类型休闲视频游戏中的学习：动作游戏与策略游戏
Evan T Smith,Kaoru Nashiro,Margaret O&#x;Connell et al.
Evan T Smith et al.
Video game based and other computerized cognitive interventions are generally efficacious in bolstering cognition in adults over the age of 60, though specific efficacy varies widely by intervention methodology. Furthermore, there is reason...
White matter differences between younger and older adults revealed by fixel-based analysis [0.03%]
基于固定分析揭示的年轻和老年受试者白质差异
Feliberto de la Cruz,Andy Schumann,Katrin Rieger et al.
Feliberto de la Cruz et al.
The process of healthy aging involves complex alterations in neural structures, with white matter (WM) changes significantly impacting cognitive and motor functions. Conventional methods such as diffusion tensor imaging provide valuable ins...