Lipofuscin autofluorescence confounds intracellular amyloid β detection in the aged mouse brain [0.03%]
脂褐素自体荧光混淆老年小鼠脑内细胞内淀粉样蛋白β检测
Godfried Dougnon,Hideaki Matsui
Godfried Dougnon
Intracellular amyloid β (Aβ) accumulation is a contentious feature of Alzheimer's disease (AD), increasingly reported in young adults and aged animal models of AD. However, autofluorescent lipofuscin granules which consist of a mixture of...
Sex differences in the association between episodic memory residual reserve index and change in executive function [0.03%]
事件记忆储备指数与执行力变化之间的性别差异
Cheyenne Chooi,Brandon E Gavett,David Ames et al.
Cheyenne Chooi et al.
Sex differences in cognitive reserve might contribute to females being disproportionately affected by Alzheimer's disease (AD). We investigated sex differences in the protective effects of cognitive reserve, and whether brain beta-amyloid a...
Identification of novel candidate loci for Alzheimer's disease and related dementias by leveraging the shared genetic basis with hippocampal volume [0.03%]
通过利用与海马体积的遗传基础共有的方式来鉴定阿尔茨海默病和相关痴呆症的新候选基因位点
Chenyang Jiang,Sven J van der Lee,Niccolò Tesi et al.
Chenyang Jiang et al.
Alzheimer's disease and related dementias (ADRD) are complex neurodegenerative disorders of which the genetic basis remains incompletely understood. Hippocampal volume loss is a core hallmark of AD. Hippocampal volume also has a strong heri...
M C Alonso-Moreno,M Gallardo-Caballero,A V Prádanos-Senén et al.
M C Alonso-Moreno et al.
The mammalian hippocampus generates new dentate granule cells (DGCs) throughout life. This process, named adult hippocampal neurogenesis (AHN), participates in hippocampal functions such as memory and mood regulation. Moreover, AHN is impai...
Neural stem cell secretome: a secret key to unlocking the power of regeneration in the adult and aging brain [0.03%]
神经干细胞分泌组分：解锁成人及老年大脑再生潜能的密钥
Soumia Abdellaoui,Lida Katsimpardi
Soumia Abdellaoui
Adult neurogenesis involves the activation of quiescent neural stem cells (qNSCs) to generate new neurons, which migrate and integrate into existing neural circuits. In addition to their role in neurogenesis, adult NSCs also secrete bioacti...
Frontal theta oscillations and cognitive flexibility: Age-related modulations in EEG activity [0.03%]
frontal theta振荡和认知灵活性：EEG活动的年龄相关调节
Margarita Darna,Christopher Stolz,Hannah-Sophia Jauch et al.
Margarita Darna et al.
Cognitive flexibility, the ability to adapt one's behaviour in changing environments, declines during aging. Electroencephalography (EEG) studies have implicated midfrontal theta oscillations in attentional set-shifting, a measure of cognit...
Nigrostriatal dopaminergic neurotransmission and resilience to peripheral systemic risk factors for gait slowing upon transition to uneven surfaces in older adult [0.03%]
黑纹状体多巴胺能神经传导与老年个体过渡到不平坦地面时步速减慢的外周系统性风险因素的抗逆性之间的关系研究
Lana M Chahine,Andrea Rosso,Ian Troidl et al.
Lana M Chahine et al.
Identifying mechanisms that compensate for slow gait speed in older adults is crucial. Dopaminergic neurotransmission curbs deleterious associations of cerebrovascular disease with gait, but whether it compensates for peripheral systemic ri...
Cellular senescence, neuroinflammation, and microRNAs: Possible interactions driving aging and neurodegeneration in the hippocampal neurogenic niche [0.03%]
细胞衰老、神经炎症和microRNA：驱动海马区神经营养生态位老化和神经退行性变的可能相互作用
O Polzer,E Kinloch,C P Fitzsimons
O Polzer
Cellular senescence influences normal physiology and ageing-related diseases, including neurodegeneration. Senescent cells accumulate with age in the brain, secreting pro-inflammatory factors that promote neuroinflammation, which has been l...
Testing the causal impact of plasma amyloid on total Tau using a genetically informative sample of adult male twins [0.03%]
利用成人男性双胞胎遗传信息样本测试血浆淀粉样蛋白对总tau的因果影响
Nathan A Gillespie,Michael C Neale,Matthew S Panizzon et al.
Nathan A Gillespie et al.
The amyloid cascade hypothesis predicts that amyloid-beta (Aβ) aggregation drives tau tangle accumulation. We tested competing causal and non-causal hypotheses regarding the direction of causation between Aβ40 and Aβ42 and total Tau (t-T...
Complex span measures of working memory do not mediate the effects of age on the P3 and N400 ERPs [0.03%]
工作记忆的复杂跨度测量不能介导年龄对P3和N400的影响
Jasmin Joshi,Chandlyr M Denaro,Alan A Hartley et al.
Jasmin Joshi et al.
Working memory (WM), the temporary maintenance of a limited amount of information in an accessible state, is required for the performance of many tasks. Studies have shown that WM demands are related to the neural processing of tasks requir...