Gray matter network properties show distinct associations with CSF p-tau 181 levels and amyloid status in individuals without dementia [0.03%]
灰质网络特性与无痴呆症个体脑脊液磷酸Tau蛋白水平及淀粉样蛋白状态的关联不同
Lorenzini Luigi,Ingala Silvia,Wottschel Viktor et al.
Lorenzini Luigi et al.
Gray matter networks are altered with amyloid accumulation in the earliest stage of AD, and are associated with decline throughout the AD spectrum. It remains unclear to what extent gray matter network abnormalities are associated with hype...
The relationship between cardiovascular risk and lifestyle activities on hippocampal volumes in normative aging [0.03%]
心血管风险和生活方式活动与正常老化过程中海马体积的关系
Vanessa Scarapicchia,Stuart MacDonald,Jodie R Gawryluk
Vanessa Scarapicchia
Background: Despite the life-course perspective of popular aging models, few studies on healthy aging to date have examined both younger and older adulthood. The current study examined how cumulative vascular risk factors...
Capillary function progressively deteriorates in prodromal Alzheimer's disease: A longitudinal MRI perfusion study [0.03%]
基于纵向MRI灌注研究的早老素型阿尔茨海默病患者微循环功能渐进性恶化
Lasse S Madsen,Rune B Nielsen,Peter Parbo et al.
Lasse S Madsen et al.
Cardiovascular risk factors are associated with the development of Alzheimer's disease (AD), and increasing evidence suggests that cerebral microvascular dysfunction plays a vital role in the disease progression. Using magnetic resonance im...
Asymmetric amyloid deposition in preclinical Alzheimer's disease: A PET study [0.03%]
阿尔茨海默病前驱期淀粉样蛋白不对称沉积的PET研究
Pernille L Kjeldsen,Peter Parbo,Kim V Hansen et al.
Pernille L Kjeldsen et al.
Introduction: The typical spatial pattern of amyloid-β (Aβ) in diagnosed Alzheimer's disease (AD) is that of a symmetrical hemispheric distribution. However, Aβ may be asymmetrically distributed in early stages of AD. ...
Aging entails distinct requirements for Rb at maintaining adult neurogenesis [0.03%]
RB在维持成人神经发生方面具有不同的衰老需求
Saad Omais,Rouba N Hilal,Nour N Halaby et al.
Saad Omais et al.
Cell cycle proteins play essential roles in regulating embryonic and adult neurogenesis in the mammalian brain. A key example is the Retinoblastoma protein (Rb) whose loss disrupts the whole neurogenic program during brain development, but ...
Age-related differences in white matter microstructure measured by advanced diffusion MRI in healthy older adults at risk for Alzheimer's disease [0.03%]
基于高级弥散MRI的健康老年人（阿尔茨海默病高危人群）白质微结构年龄相关差异的研究
Alice Motovylyak,Nicholas M Vogt,Nagesh Adluru et al.
Alice Motovylyak et al.
Neurite orientation dispersion and density imaging (NODDI) is an advanced diffusion imaging technique, which can detect more distinct microstructural features compared to conventional Diffusion Tensor Imaging (DTI). NODDI allows the signal ...
Evaluating associations of RNFL thickness and multifocal VEP with cognitive assessment and brain MRI volumes in older adults: Optic nerve decline and cognitive change (ONDCC) initiative [0.03%]
老年人视网膜神经纤维层厚度和多焦点视觉诱发电位与认知评估及脑MRI体积关联的评价：optic nerve decline and cognitive change(ONDCC)计划
Ting Shen,Samran Sheriff,Yuyi You et al.
Ting Shen et al.
To examine the relationships of retinal structural (optical coherence tomography) and visual functional (multifocal visual evoked potentials, mfVEP) indices with neuropsychological and brain structural measurements in healthy older subjects...
Influence of endogenous estrogen on a network model of female brain integrity [0.03%]
内源性雌激素对女性大脑网络完整性影响的模拟研究
Janelle T Foret,Marie Caillaud,Drew D Gourley et al.
Janelle T Foret et al.
Recent reports document sex differences in midlife brain integrity and metabolic health, such that more relationships are detectable between metabolic syndrome (MetS) components and markers of brain health in females than in males. Midlife ...
Mehrane Mehramiz,Tenielle Porter,Simon M Laws et al.
Mehrane Mehramiz et al.
Sleep plays a major role in brain health, and cognition. Disrupted sleep is a well-described symptom of Alzheimer's disease (AD). However, accumulating evidence suggests suboptimal sleep also increases AD risk. The deacetylase Sirtuin 1 (Si...
Hemispheric dissociations in regions supporting auditory sentence comprehension in older adults [0.03%]
老年人听觉句子理解的半球差异性
Yune Sang Lee,Chad S Rogers,Murray Grossman et al.
Yune Sang Lee et al.
We investigated how the aging brain copes with acoustic and syntactic challenges during spoken language comprehension. Thirty-eight healthy adults aged 54 - 80 years (M = 66 years) participated in an fMRI experiment wherein listeners indica...