Increased cancer mortality among Japanese individuals with hyperinsulinemia [0.03%]
高胰岛素血症日本人中的癌症死亡率升高
Sakurako Kira,Chikako Ito,Rumi Fujikawa et al.
Sakurako Kira et al.
Aims: To evaluate the effect of hyperinsulinemia on cancer death, we clarified the association between hyperinsulinemia and cancer mortality among Japanese individuals. ...
Oxidized albumin in blood reflects the severity of multiple vascular complications in diabetes mellitus [0.03%]
血液中氧化白蛋白反映糖尿病多血管并发症的严重程度
Yuka Kobayashi,Ryo Suzuki,Keiko Yasukawa et al.
Yuka Kobayashi et al.
Albumin has an oxidized form, known as non-mercaptalbumin (HNA), which reflects systemic oxidative stress. The association between serum HNA levels and diabetic complications are yet to be reported. In this cross-sectional study, we investi...
The mitochondrial transcription machinery genes are upregulated in acute myeloid leukemia and associated with poor clinical outcome [0.03%]
急性髓系白血病中的线粒体转录机器基因上调并与不良临床结果相关
Sharon Wu,Nicole Fahmy,Houda Alachkar
Sharon Wu
Background: Acute myeloid leukemia (AML) is characterized by rapid growth of abnormal blasts that overcrowd normal hematopoiesis. Defective mitochondrial biogenesis has been implicated in AML, which we believe is partly d...
Hepatic CREBZF as a novel transcriptional regulator of the lipogenic pathway [0.03%]
肝CREBZF作为脂质生成途径的新转录调节因子
Junli Liu
Junli Liu
Hypermetabolism in critically ill patients with COVID-19 and the effects of hypothermia: A case series [0.03%]
COVID-19重症患者的高代谢状态及低体温的影响：病例系列研究
Pey-Jen Yu,Hugh Cassiere,Karl Bocchieri et al.
Pey-Jen Yu et al.
Background: We have observed that critically ill patients with COVID-19 are in an extreme hypermetabolic state. This may be a major contributing factor to the extraordinary ventilatory and oxygenation demands seen in thes...
The therapeutic potential of colchicine in the complications of COVID19. Could the immunometabolic properties of an old and cheap drug help? [0.03%]
秋水仙碱在COVID19并发症中的治疗潜力。一种古老廉价的药物的免疫代谢特性是否有帮助？
Sandro Augusto Ribeiro,Cassio Lopes,Ricardo Amaral et al.
Sandro Augusto Ribeiro et al.
The present study analyzes the importance of the inflammasome that involves the NLRP3 complex in the state of hypercytokinemia observed in patients with COVID-19, significantly increasing IL-1β, IL18, IL-6, and TNF. Unfortunately, improvin...
A novel stable isotope tracer method to simultaneously quantify skeletal muscle protein synthesis and breakdown [0.03%]
一种新的稳定同位素示踪剂方法，可同时量化骨骼肌蛋白合成和分解
Hannah Crossland,Kenneth Smith,Philip J Atherton et al.
Hannah Crossland et al.
Background/aims: Methodological challenges have been associated with the dynamic measurement of muscle protein breakdown (MPB), as have the measurement of both muscle protein synthesis (MPS) and MPB within the same experi...