Deoxycholic Acid and Lipoteichoic Acid cooperatively drive macrophage M2/M1 polarization via TGR5/STAT3 and TLR2/NF-κB to fuel HCC progression in obesity [0.03%]
脱氧胆酸和脂壁酸通过TGR5/STAT3和TLR2/NF-κB协同驱动巨噬细胞M2/M1极化以促进肥胖相关HCC进展
Jian Wu,Wen Zheng,Xu-Zhen Ding et al.
Jian Wu et al.
Background: Obesity-related hepatocellular carcinoma (HCC) is associated with gut microbiota dysbiosis. However, the specific roles of key microbial metabolites, deoxycholic acid (DCA) and lipoteichoic acid (LTA), in modu...
Cross-sectional mediation analysis of systemic inflammation in the association between serum uric acid and diabetic kidney disease: Evidence from NHANES 1999-2018 [0.03%]
基于NHANES 1999-2018数据的血尿酸与糖尿病肾病横断面中介分析：系统性炎症的介导作用
Jiaying Wang,Weijing Liu,Jiaoyan Li et al.
Jiaying Wang et al.
Objective: To investigate whether systemic inflammation, quantified by the Aggregate Index of Systemic Inflammation (AISI), mediates the association between uric acid (UA) and diabetic kidney disease (DKD). ...
Gestational diabetes alters prefrontal neurochemistry and disrupts maternal behaviors: Role of Fibrillin-1, serotonin, and TNF-α in rats [0.03%]
妊娠期糖尿病改变前额叶神经化学并破坏母性行为：弹力蛋白1、血清素和肿瘤坏死因子在大鼠中的作用
Samira Khayat,Hamed Fanaei,Abdolvahed Safarzaei
Samira Khayat
Objective: Gestational diabetes mellitus (GDM) is a metabolic disorder that can impact various aspects of maternal behavior and neurochemical processes. This study aimed to investigate the effects of GDM on FBN1 (fibrilli...
Close multilevel links between metabolic dysfunction-associated steatotic liver disease and type 2 diabetes mellitus [0.03%]
代谢紊乱相关脂肪性肝病与2型糖尿病之间密切的多级联系
A G Holleboom,S M Francque,K Cusi et al.
A G Holleboom et al.
Since liver cirrhosis due to Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD) was first described in patients with diabetes mellitus, the prevalence and severity of this liver disease have increased dramatically, driven by t...
Association between triglyceride glucose-body mass index and MASH, cardiovascular disease in MASLD patients: a cross-sectional study and machine learning analysis [0.03%]
TG×BMI与MASLD患者MASH、心血管疾病的相关性研究：横断面研究及机器学习分析
Xiaoxuan Tang,Fenglan Wang,Yiran Liu et al.
Xiaoxuan Tang et al.
Background: The triglyceride glucose-body mass index (TyG-BMI) is a useful marker for metabolic dysfunction-associated steatotic liver disease (MASLD) and cardiovascular disease (CVD). However, its ability to differentiat...
Update on the impact of lipid and glucose control on diabetic wound healing [0.03%]
糖尿病伤口愈合的脂质和血糖控制影响的研究进展
Rui Sun,Yang Xu,Zhenjun Ji et al.
Rui Sun et al.
This review summarizes current insights into the molecular mechanisms by which hyperglycemia and dyslipidemia contribute to chronic diabetic wounds. It discusses the roles of key metabolic pathways, including the hexosamine biosynthetic and...
Prevalence of normal weight obesity among adults in Southeast Asia: Insights from a systematic review and meta-analysis [0.03%]
东南亚成人正常体重肥胖的患病率：来自系统评价和meta分析的见解
K G Sruthi,C Aditya,Paramjot Panda et al.
K G Sruthi et al.
Background: Normal Weight Obesity (NWO) describes individuals with a normal body mass index (BMI) but elevated body fat percentage (BF%), placing them at increased risk for cardiometabolic complications. This condition is...
Probiotics, prebiotics, synbiotics, and FMT for glycemic control: A systematic review of clinical efficacy and mechanistic readouts in type 2 diabetes and related dysglycemia [0.03%]
益生菌、益生元、合生元和粪菌移植在2型糖尿病患者血糖控制中的临床疗效及其机制：系统综述
Neda Shalbaf,Soheila Sadeghi,Sina Homaee et al.
Neda Shalbaf et al.
Objective: To systematically evaluate the clinical efficacy of probiotics, prebiotics, synbiotics, and fecal microbiota transplantation (FMT) on glycemic control in adults with type 2 diabetes (T2D) and related dysglycemi...
The role of pancreatic islet macrophages in type 2 diabetes mellitus: from underlying pathological mechanisms to therapeutic target discovery [0.03%]
糖尿病 mellitus中胰岛巨噬细胞的作用：从潜在的病理机制到治疗靶点发现
Zhongpeng Qiu,Dejing Shang
Zhongpeng Qiu
The pathogenesis of type 2 diabetes mellitus (T2DM) is closely associated with chronic inflammation within the islet microenvironment, where pancreatic islet macrophages serve as central orchestrators of local immune regulation. This review...
Novel causal associations between plasma metabolites and prostate cancer risk revealed by mendelian randomization [0.03%]
孟德尔随机化揭示新的因果代谢物与前列腺癌风险之间的联系
Hanghang Chen,Huiduo Zhao,Bingxin Meng et al.
Hanghang Chen et al.
Background: Prostate cancer (PCa) is a major global health concern for men, yet its underlying metabolic mechanisms are not fully understood. Identifying causal metabolites could reveal novel pathways for risk assessment ...