Calcium waves and nuclear tension changes coordinate mechanical stress dissipation in locally folded epithelia [0.03%]
钙波和核张力变化协调局部折叠上皮组织中的机械应力耗散
Marvin Brun-Cosme-Bruny,Lydia Pernet,Kenny Elias et al.
Marvin Brun-Cosme-Bruny et al.
Epithelia are continuously exposed to biomechanical forces such as compression, stretch, and shear stress arising from their dynamic microenvironments. Changes in tension, including stretch, trigger cell rearrangements, divisions, and trans...
Identity rather than 3D position informs splicing of rare introns in the human genome [0.03%]
身份而非三维位置决定人类基因组中稀有内含子的拼接
Saren M Springer,Katherine Fleck,Kaitlin N Girardini et al.
Saren M Springer et al.
Three-dimensional genome organization influences splicing, yet how introns, particularly rare introns, are arranged within the nucleus and whether this organization contributes to splicing have not been fully explored. We mapped the organiz...
Multiplexing of visual-auditory signals in a predominantly auditory brain region [0.03%]
视觉听觉信号在以听觉为主的脑区的多路复用现象
Meredith N Schmehl,Yunran Chen,Surya T Tokdar et al.
Meredith N Schmehl et al.
A recent theory of neural representation postulates that neurons may fluctuate between encoding multiple items. Such competition for representation is plausible when the stimuli evoke activity in overlapping neural populations. What about w...
Cecilia Marini,Maddalena Ghelardoni,Sonia Carta et al.
Cecilia Marini et al.
The endoplasmic reticulum (ER) supports essential biosynthetic and quality control functions. These processes rely on sustained energy supply and precise redox control within the ER lumen. While ATP can be imported from mitochondria, pyridi...
Combining DNA methylation features and clinical characteristics predicts ketamine treatment response for PTSD [0.03%]
结合DNA甲基化特征和临床表型预测PTSD的氯胺酮治疗反应
Amir Valizadeh,John D Roache,Xinyu Zhang et al.
Amir Valizadeh et al.
Post-traumatic stress disorder (PTSD) exhibits extensive clinical and biological variability, making treatment challenging. The Consortium to Alleviate PTSD (CAP)-ketamine trial, the largest randomized study of ketamine for PTSD, found no o...
Deep generative modeling captures maturation-dependent pairing patterns in human antibodies [0.03%]
深度生成模型捕获人类抗体成熟度依赖的配对模式
Lea Brönnimann,Thomas Lemmin,Chiara Rodella
Lea Brönnimann
Understanding antibody heavy-light chain pairing is critical for decoding immune repertoire architecture and designing therapeutic antibodies, yet most sequence databases lack paired chain information. To address this gap, we developed a tw...
RNAi-based screen for pigmentation in Drosophila melanogaster reveals regulators of brain dopamine and sleep [0.03%]
利用果蝇Drosophila melanogaster的RNA干扰筛选色素合成基因并发现脑多巴胺和睡眠调控新因子
Samantha L Deal,Danqing Bei,Shelley B Gibson et al.
Samantha L Deal et al.
The dopaminergic system has a large role in behavior and neurological disease, and understanding dopamine level regulation in vivo is critical. To identify dopamine regulators, we utilized Drosophila melanogaster cuticle pigmentation, where...
A potential application of dual-mode metafilm for enhanced second harmonic generation in refractive index and angle measurement [0.03%]
双工作模式metafilm在折射率和角度测量中的二次谐波增强效应的潜在应用研究
Xiang Li,Jun-Yang Sui,Hai-Feng Zhang
Xiang Li
Second harmonic generation (SHG) is a nonlinear phenomenon in which incident electromagnetic wave signals are converted into harmonic signals with doubled frequency. In this paper, a method has been proposed to enhance the SHG using metafil...
Systematic review and meta-analysis of cardiac complications in acute pancreatitis [0.03%]
急性胰腺炎的心脏并发症的系统评价和meta分析
Veronika Lillik,Mahmoud Obeidat,Dániel Sándor Veres et al.
Veronika Lillik et al.
Cardiovascular abnormalities are associated with acute pancreatitis (AP). Here, we temporarily link these abnormalities to AP outcomes. We systematically searched PubMed, EMBASE, and Cochrane on 5th November 2023 and included 44 studies (n ...
Otubain deubiquitinases: Multi-layered regulators of cell fate, development, and stress responses across kingdoms [0.03%]
奥图贝林脱泛素酶：跨王国细胞命运、发育和压力反应的多层调节因子
Jie Yang,Yijie Zhang,Qinhu Wang et al.
Jie Yang et al.
Otubain deubiquitinating enzymes are pivotal regulators of cell fate, development, and stress responses across animals, plants, and fungi. This review highlights their conserved and pleiotropic functions in orchestrating proteostasis, organ...