CK1δ-dependent SNAPIN dysregulation drives lysosomal failure in HIV-1 Vpr-exposed neurons: A targetable mechanism in HAND [0.03%]
HIV-1 Vpr通过CK1δ依赖性SNAPIN异常调节驱动神经元溶酶体功能障碍：HIV相关神经病变的可靶向机制
Bassel E Sawaya,Maryline Santerre
Bassel E Sawaya
HIV-associated neurocognitive disorders (HANDs) persist in nearly 40% of virally suppressed individuals despite antiretroviral therapy (ART). Lysosomal dysfunction has emerged as a key contributor to HAND pathogenesis, yet the molecular mec...
Pei-Cheng Shih,Masato Hirano,Shinichi Furuya
Pei-Cheng Shih
Executing complex movement sequences from memory is crucial for skillful motor actions such as musical performance and sports. While chunking helps memorization during practice, transitions between chunks may become vulnerable during execut...
Activation phenotypes defined by the coordinated expression of activation markers discriminate TCR-mediated and bystander T cell responses [0.03%]
激活表型由活化标志物的协调表达定义，可区分TCR介导和旁观者T细胞反应
Tamara J C Schenk,Martijn Vos,Yannick van Sleen et al.
Tamara J C Schenk et al.
Studying activation of antigen-specific T cells is essential for understanding adaptive immune response to pathogens, tumors, and vaccines. Flow cytometry is commonly used to identify antigen-specific T cells based on the induction of activ...
Ecological barrier crossing strategies in small migratory birds depend on wing morphology and plumage color [0.03%]
小型迁徙鸟类的生态屏障穿越策略依赖于翅膀形态和羽毛颜色
Paul Dufour,Raphaël Nussbaumer,Martins Briedis et al.
Paul Dufour et al.
Recent tracking technologies have revealed remarkable diel flight altitude changes over the Sahara Desert in small migratory birds. However, the drivers and traits behind these strategies remain poorly understood, partly because few species...
Lin Zhu,Wujianan Sun,Kun Chen et al.
Lin Zhu et al.
Autoimmune pathologies arise from dysregulated immune activation, yet conserved molecular programs across autoimmune contexts remain incompletely characterized. Here, we analyzed integrative single-cell RNA sequencing data of over 1.3 milli...
A low-cost IoT architecture with RF communication and data analytics for real-time productivity monitoring in garment manufacturing [0.03%]
一种低成本的物联网架构：具有射频通信和数据分析功能的服装制造业实时生产率监测方法
Cong Duy Vo,Thanh-Truong Nguyen,Duy Anh Dang
Cong Duy Vo
Productivity control in garment sewing lines is a critical factor in ensuring on-time delivery and competitiveness in the apparel industry. In many developing countries, however, line-level monitoring remains manual, often performed at the ...
Mesoscopic analysis of GABAergic marker expression in acetylcholine neurons in the whole mouse brain [0.03%]
乙酰胆碱能神经元伽马氨基丁酸能标记在整个小鼠脑内的介观分析研究
R Oliver Goral,Snehashis Roy,Caroll A Co et al.
R Oliver Goral et al.
In the central nervous system, acetylcholine (ACh) neurons coordinate neural network activity required for higher brain functions, such as attention, learning, and memory, as well as locomotion. Disturbances in cholinergic signaling have be...
Theoretical and computational study of a quad-band optical switch and three-bit encoder based on a graphene metasurface [0.03%]
基于石墨烯超表面的四波长光学开关和三进制编码器的理论与计算研究
Jiacheng Dai,Jun Zhu
Jiacheng Dai
To address the issues of insufficient tunability and high losses in existing metamaterial devices, this study proposes a tunable metamaterial device based on graphene. Coupling effects among these units under normal-incidence x-polarized te...
United multi-omics and machine learning refine regulatory T cell-defined hepatocellular carcinoma subtypes [0.03%]
整合组学和机器学习精确定义调节性T细胞肝癌亚型
Wanli Zhang,Chengdong Liu,Aishun Jin et al.
Wanli Zhang et al.
Hepatocellular carcinoma (HCC) is highly heterogeneous and aggressive, and the absence of precision individual treatment regimen enables repeated immune escape. Exploiting regulatory T cell (Treg) marker genes as key classifiers, we used 10...
Erratum: Integrated transmission-reflection strong-field terahertz time-domain spectroscopy [0.03%]
erratum：强场太赫兹时域光谱的透射/反射集成传输研究
Jianghao Li,Aojie Xu,Deyin Kong et al.
Jianghao Li et al.
[This corrects the article DOI: 10.1016/j.isci.2025.114263.]. © 2025 The Author(s).
Published Erratum
iScience. 2026 Jan 8;29(1):114599. DOI:10.1016/j.isci.2025.114599 2026