Combined prostate cancer vaccine plus immune checkpoint inhibition synergizes to eliminate prostate cancer [0.03%]
联合前列腺癌疫苗和免疫检查点抑制协同作用消除前列腺癌
Gabriel Carreno-Galeano,Seema Dubey,Kenneth A Iczkowski et al.
Gabriel Carreno-Galeano et al.
Immunotherapy has improved outcomes in many cancers, yet the clinical benefits remain limited in prostate cancer. We evaluated whether an adenovirus-based bivalent prostate cancer vaccine (Ad-PS2) targeting two tumor antigens could be stren...
Comparative evaluation of three automated urine sediment analyzers excluding cutoff-related trade-offs [0.03%]
排除切值相关权衡的三种自动化尿沉渣分析仪的比较评价
Jinho Lee,Heekang Choi,Hanmil Jang et al.
Jinho Lee et al.
Performance comparison of automated urine sediment analyzers is difficult due to cutoff-related trade-offs. In this study, we evaluated and compared UF-5000, UAS800, and Cobas u701 using receiver operating characteristic (ROC) analysis. A t...
Multimodal-multiscale hybrid fusion network for automated esophageal cancer diagnosis [0.03%]
用于自动食管癌诊断的多模态-多尺度混合融合网络
Zenebe Markos Lonseko,Helen Haile Hayeso,Tan Gan et al.
Zenebe Markos Lonseko et al.
Accurate and early diagnosis of esophageal cancer (EC) remains challenging due to heterogeneous imaging characteristics and the complexity of integrating multimodal data. This study proposes a multimodal-multiscale hybrid fusion network (MH...
Zhigancao decoction alleviates Parkinson's disease via inhibiting TNF/NF-κB and Ras/ERK-mediated neuroinflammation and apoptosis [0.03%]
炙甘草汤通过抑制TNF/NF-κB和Ras/ERK介导的神经炎症和细胞凋亡来改善帕金森病症状
Jiakang Zhang,Xinlang Yu,Yuan Fang et al.
Jiakang Zhang et al.
Parkinson's disease (PD) is characterized by the progressive loss of dopaminergic neurons, with neuroinflammation and apoptosis serving as key pathological drivers. In this study, we investigated the traditional herbal formula Zhigancao Dec...
Database of recurrent mutations, an unbiased web resource to browse recurrent mutations in cancers [0.03%]
肿瘤癌症中反复出现的突变数据库——一个无需偏见浏览癌症中反复出现的突变的网络资源
Deepankar Chakroborty,Katri Vaparanta,Bishwa Ghimire et al.
Deepankar Chakroborty et al.
Existing cancer-associated variant databases contain biases arising from duplicate entries and the inclusion of targeted sequencing panels, which interfere with accurate estimation somatic mutation frequency in cancer cohorts. To address th...
DACIT device for axon cancer cell interaction testing in 2D and 3D [0.03%]
用于二维和三维中轴突与癌细胞相互作用检测的DACIT设备
Ines Velazquez-Quesada,Vahid Alizadeh,Kara Allison et al.
Ines Velazquez-Quesada et al.
Peripheral innervation is increasingly recognized as a critical regulator of tumor progression, yet in vitro models that enable controlled study of axon-cancer cell interactions remain limited. Here, we present the Device for Axon-Cancer ce...
The GF-NEO discovery platform unveils a [KQE][DG] sequence motif within fusion neoantigens in pediatric cancer [0.03%]
GF-NEO发现平台揭示了儿童癌症融合新抗原中的[KQE][DG]序列基序
Christopher Savoie,Zhaoguan Wu,Frederic Saab et al.
Christopher Savoie et al.
Gene fusions (GFs) are critical events in pediatric oncology, often serving as oncogenic drivers. However, fusion proteins and their derived neoantigens (GF-NEOs) remain underexplored for targeted immunotherapy. We developed ProteoFusioNEO,...
The basal ganglia mediate the inter-hemispheric transfer of complex tool-use skill [0.03%]
基底神经节介导复杂工具使用技能的半球间传递
Sayori Takeda,Kouji Takano,Kimihiro Nakamura
Sayori Takeda
Motor skills learned in one hand generalize to the other hand via plastic changes in motor systems. Such "intermanual transfer" may arise during complex tool-use learning, but its neural underpinnings remain unknown. Using resting-state fMR...
Advances in mitochondrial-targeted colorectal cancer therapy: Mechanistic insights and clinical translation [0.03%]
线粒体靶向结直肠癌治疗进展：机制见解与临床转化
Hao Che,Zhen-Jun Li,Ling Xu et al.
Hao Che et al.
Colorectal cancer (CRC) therapy is challenged by drug resistance and limited treatment efficacy. Mounting evidence now positions mitochondrial dysfunction as a central mediator of these challenges, making it a compelling therapeutic target....
Production and physicochemical characterization of exopolysaccharides from the salt-tolerant actinobacterial strain Zhihengliuella halotolerans DT-Z1 [0.03%]
一株耐盐放线菌Zhihengliuella halotolerans DT-Z1胞外多糖的发酵生产及其理化性质研究
Chengyang Wang,Guangyang Jiang,Longzhan Gan et al.
Chengyang Wang et al.
Extremophiles often produce exopolysaccharides (EPSs) as a strategy in harsh environments, thus attracting significant interest for their properties and applications. A salt-tolerant EPS-producing Zhihengliuella halotolerans DT-Z1 was acqui...