Bta-miR-30f promotes adipogenesis and unsaturated fatty acid accumulation by targeting RAD23B in buffalo intramuscular preadipocytes [0.03%]
Bta-miR-30f通过靶向RAD23B促进水牛肌间前脂肪细胞的脂肪生成和不饱和脂肪酸积累
Ruirui Zhu,Hao Tian,Fangfang Zou et al.
Ruirui Zhu et al.
The intramuscular fat content and the unsaturated fatty acid (UFA) composition are both critical indicators of buffalo meat quality. While microRNAs regulate fatty acid metabolism, their specific roles in buffaloes remain unclear. Our previ...
Unifying thermopower: entropy and specific heat in magnetic, superconducting, nanoscale, and frustrated systems [0.03%]
统一的塞贝克效应：磁性、超导、纳米和阻挫系统中的熵和比热容
Morteza Jazandari,Jahanfar Abouie,Daryoosh Vashaee
Morteza Jazandari
Thermopower, a key parameter in thermoelectric performance, is often linked to either specific heat or entropy, yet the governing quantity has remained elusive. Here we present a unified framework showing that entropy per carrier, not speci...
Interpretable machine learning for predicting low-dose methylprednisolone effectiveness in long COVID [0.03%]
可解释机器学习预测低剂量甲基强的松龙治疗长新冠的有效性
Jisheng Zhang,Yang Chen,Aijun Zhang et al.
Jisheng Zhang et al.
Long COVID is a chronic, multisystem disease with limited response to conventional treatments. While low-dose methylprednisolone has shown effectiveness in some patients, individual responses vary, and accurate predictive tools are lacking....
Yuichiro Adachi,Allison M Williams,Masashi Masuda et al.
Yuichiro Adachi et al.
Stress granules (SGs) are cytoplasmic ribonucleoprotein condensates formed in response to stress-induced inhibition of mRNA translation and polysome disassembly. Despite the broad interest in SG assembly and disassembly in response to acute...
Dimensionality-modulated generative AI for safe biomedical dataset augmentation [0.03%]
用于安全的生物医学数据集增强的维度调节生成式AI
Jörn Lötsch,André Himmelspach,Dario Kringel
Jörn Lötsch
Generative AI can expand small biomedical datasets but may amplify noise and distort statistical relationships. We developed genESOM, a framework integrating an error control system into a generative AI method based on emergent self-organiz...
Structural analyses and substrate profiling of PPEP-3 provide new insights into the molecular basis of Pro-Pro endopeptidase specificity [0.03%]
对PPEP-3的结构分析及底物谱研究揭示了Pro-Pro内肽酶特异性的分子机制的新见解
Bart Claushuis,Fabian Wojtalla,Lisa Papenhagen et al.
Bart Claushuis et al.
Pro-Pro endopeptidases (PPEPs) are secreted bacterial enzymes that uniquely cleave peptide bonds between adjacent proline residues. Their active site accommodates six substrate residues (P3 to P3'), with interactions at these positions dete...
Comparative transcriptomic analysis of embryonic stem cells across mammalian species [0.03%]
跨物种哺乳动物胚胎干细胞的比较转录组分析
Yifei Fang,Yue Su,Richard Meisel et al.
Yifei Fang et al.
Pluripotency, the ability of cells to self-renew and differentiate into all body lineages, is vital for mammalian early development. This study presented a comprehensive comparative transcriptomic analysis of embryonic stem cells across mul...
AI-Carbon-Energy: Spillover effects and drivers in interconnected markets [0.03%]
人工智能-碳-能源：互联互通市场中的溢出效应及驱动因素分析
Mingming Zhang,Yue Pan,Bin Su et al.
Mingming Zhang et al.
This study explores the spillover effects between the AI market, international carbon market, and energy markets based on a time-varying parameter vector autoregression model. Further, the study uses a multivariate quantile-to-quantile regr...
Ubiquitination and degradation of CD47 enhances macrophage phagocytosis of hemolytic erythrocytes [0.03%]
CD47泛素化降解促进巨噬细胞清除溶血性红细胞
Yafen Wang,Xiaoshuang Wu,Xinlei Li et al.
Yafen Wang et al.
The destruction of red blood cells by classical complement activation can form erythrocyte ghosts in immune-mediated hemolysis. However, the mechanisms involved in clearing these membrane remnants remain to be elucidated. In this study, a c...
Contrasting whole-genome diversity patterns and adaptation in honeybees from two southern European glacial refugia [0.03%]
来自两个南部欧洲冰川避难所的整个蜂群多样性模式及适应性的对比研究
Carlos A Yadró Garcia,Dora Henriques,Giovanni Cilia et al.
Carlos A Yadró Garcia et al.
Human-driven environmental change makes understanding genetic variation essential for protecting keystone species such as the honeybee, Apis mellifera. We compared whole-genome mitonuclear variation in subspecies inhabiting the Iberian and ...