Advanced human organoid-on-chip with physiological cellular complexity reveals bidirectional secretion patterns [0.03%]
具有生理细胞复杂性的先进人体类器官芯片揭示了双向分泌模式
Inga Viktoria Hensel,Szabolcs Éliás,Michelle Steinhauer et al.
Inga Viktoria Hensel et al.
Intestinal epithelial cells are essential for maintaining gut homeostasis, serving as a physical barrier separating luminal content from the immune compartment. They are crucial for balancing tolerance to commensal and protection from patho...
BRD3 PROTAC degrader targets H3K18ac to alleviate retinal microglia-driven uveitis [0.03%]
靶向BRD3降解剂通过缓解视网膜小胶质细胞驱动的葡萄膜炎治疗H3K18ac相关疾病
Zhi Zhang,Tianlong Lan,Yongbo Liu et al.
Zhi Zhang et al.
Uveitis is a sight-threatening intraocular inflammation in which the proinflammatory immune response driven by retinal microglia is a key contributor. Proteolysis targeting chimera (PROTAC) targeting bromodomain and extraterminal (BET) prot...
Arhgef7 is essential for granule cell precursor proliferation and migration during cerebellum development [0.03%]
Arhgef7对小脑发育过程中颗粒细胞前体增殖和迁移是必不可少的
Vanesa Jiménez-Amilburu,Hugo Ducuing,Nursen Balekoglu et al.
Vanesa Jiménez-Amilburu et al.
During cerebellar development, granule cell precursors (GCPs) undergo a series of tightly regulated events, including proliferation, migration, and differentiation. Arhgef7, a guanine nucleotide exchange factor for Rac1 and Cdc42, plays a c...
Manipulating electronic properties of two-dimensional MXenes Cr2TiC2FCl by phonon vibration [0.03%]
二维MXene材料Cr2TiC2FCl的声子振动及其对电子结构的影响
Ke Wang,Jiaxiang Li,Kai Ren et al.
Ke Wang et al.
Although the manipulation of physical properties is common in applications of two-dimension (2D) materials, it is rare to tailor electronic properties by phonon vibration. In this article, we tailor the electronic band structure of Cr2TiC2F...
Intuitive and deliberative processes underlying commitment signaling for cooperative assortment [0.03%]
合作型信号传递中的直觉与反思过程研究
Martin Lang,Alexandra Ružičková,Katarína Čellárová et al.
Martin Lang et al.
While costly signals of commitment were proposed to facilitate cooperative assortment in humans, little is known about cognitive processes facilitating the reliability of such commitment signals. Across three studies (total N = 2,223), we t...
Ámbar Pérez-García,Graciela Amanda,José F López et al.
Ámbar Pérez-García et al.
Plastic pollution threatens terrestrial and aquatic ecosystems, and rivers play a central role in transporting and retaining plastics across landscapes. Effective mitigation requires scalable methods to identify riverine plastic accumulatio...
Microplastic contamination in the pristine waters of Tilicho Lake, Nepal: A groundbreaking study in the high-altitude himalayas [0.03%]
尼泊尔希姆拉莱的微塑料污染：蒂利科湖的洁净水域受到威胁
Sahil Shrestha,Ajaya Subedi,Michael J Angove et al.
Sahil Shrestha et al.
Microplastics (MPs) are studied extensively in various environments worldwide; however, their presence in remote, high-altitude freshwater lakes remains underreported. These alpine lakes serve as both upstream water sources and sinks for MP...
Fluorescence tracking Treg movement identifies anti-CCR8 and radiation as a therapeutic combination [0.03%]
荧光追踪Treg运动表明抗CCR8与放射治疗相结合的疗法有效
David J Friedman,Sina Ramin,Tiffany Blair et al.
David J Friedman et al.
Radiation therapy (RT) is recognized for its ability to induce DNA damage within cancer cells, leading to cancer cell death and promotion of anti-tumor immune responses. However, this beneficial effect is often counterbalanced by the presen...
Jinlin Hang,Meng Chen,Weibin Ma et al.
Jinlin Hang et al.
Oxidative coupling and cyclocondensation reactions to produce imidazopyridine have been attractive methodologies because of their inherent atom- and step-economy, which have been well established using exogenous oxidants, especially I2. How...
FGFR signaling and neddylation facilitate SARS-CoV-2 infection by modulating interferon induction and viral entry, respectively [0.03%]
成纤维细胞生长因子信号和泛素化促进SARS-CoV-2感染通过调节干扰素诱导和病毒进入
Alberto Felix-Lopez,Joaquin Lopez-Orozco,Mohamed Elaish et al.
Alberto Felix-Lopez et al.
SARS-CoV-2 is the causative agent of COVID-19, and although vaccines have reduced disease severity, emerging variants remain a significant public health issue. Broadly effective therapeutics, particularly those targeting host pathways essen...