Convolvulus pluricaulis confers antidepressant and antioxidant effects through conserved metabolic and molecular pathways in Drosophila [0.03%]
旋花多茎草通过保守的代谢和分子通路在果蝇中产生抗抑郁和抗氧化作用
Shreyasi Mitra,Amit Kumar,Manish Pandey et al.
Shreyasi Mitra et al.
Convolvulus pluricaulis (shankhpushpi) is a traditional herb used to treat depression and anxiety. Using Drosophila melanogaster as a model, we identified conserved metabolic and molecular pathways mediating its neuroprotective effects. Met...
Context-dependent NMDA receptor dysfunction predicts seizure treatment in mice with human GluN1 variant [0.03%]
人GLUN1变异小鼠的上下文相关N-甲基-D天冬氨酸受体功能障碍可预测发作治疗效果
Sridevi Venkatesan,Daria Nazarkina,Megan T Sullivan et al.
Sridevi Venkatesan et al.
Mutations in N-methyl-D-aspartate receptors (NMDARs) cause epilepsy and profound cognitive impairment, though the underlying subunit-specific vulnerabilities remain unclear. We investigate the impact of a severe human variant in the lurcher...
Deriving connectivity from spiking activity in detailed models of large-scale cortical microcircuits [0.03%]
从大规模皮层微电路的详细模型中根据突触活动推导连接性
Faraz Moghbel,Muhammad Taaha Hassan,Alexandre Guet-McCreight et al.
Faraz Moghbel et al.
Inferring large-scale cortical microcircuit connectivity is essential for uncovering how information is processed in the brain. A common method in vivo uses short-lag spike cross-correlations to derive putative monosynaptic connections, but...
AI enhancing differential diagnosis of acute chronic obstructive pulmonary disease and acute heart failure [0.03%]
人工智能辅助慢性阻塞性肺病和急性心力衰竭的鉴别诊断
Yu Lao,Hao Ren,Zhenxin Ma et al.
Yu Lao et al.
Differentiating acute exacerbation of chronic obstructive pulmonary disease (AECOPD) from acute heart failure (AHF) is clinically challenging due to overlapping symptoms, especially in resource-limited settings lacking radiological/ultrason...
Consensus and dissent between climate activists and oil and gas employees in the United Kingdom [0.03%]
英国气候活动家和油气工人之间的共识与分歧
Ella Exley,Krista Halttunen,Iain Staffell
Ella Exley
With global temperatures breaching 1.5°C above pre-industrial levels, the energy system must undergo rapid, radical transformation to avoid irreversible ecosystem damage. This complex challenge is exacerbated by polarized views between act...
Homo sapiens could have hunted with bow and arrow from the onset of the early Upper Palaeolithic in Eurasia [0.03%]
从东亚早更新世初期开始智人可能就已经使用弓箭狩猎了
Keiko Kitagawa,José-Miguel Tejero,Reuven Yeshurun et al.
Keiko Kitagawa et al.
The evolution of projectile technology remains a central topic in palaeoanthropological discussions on prey acquisition, subsistence strategies, and interpersonal violence. A linear technological development is traditionally assumed from ha...
Non-invasive detection of bone marrow fibrosis in myeloproliferative neoplasms using cell-free RNA [0.03%]
采用无细胞RNA检测骨髓纤维化中的骨髓增生性肿瘤
Mohamed Saad,Stijn N R Fuchs,Carmen Schalla et al.
Mohamed Saad et al.
Myeloproliferative neoplasms (MPNs), particularly with myelofibrosis (MF), involve a disrupted perivascular hematopoietic niche, ultimately leading to bone marrow fibrosis. We asked if the transcriptome in cell-free RNA (cf-RNA) from the pe...
Gut microbiota and Parkinson's disease: exploring pathogenesis and potential therapeutic strategies from a gut-brain axis perspective [0.03%]
从脑-肠轴角度探索帕金森病的发病机制及潜在治疗策略——聚焦肠道菌群研究进展
Xiayu Jin,Jirui Wei,Xudong Min et al.
Xiayu Jin et al.
Parkinson's disease (PD) is a prevalent neurodegenerative disorder with a global prevalence exceeding 1‰, posing a significant public health challenge. Although the pathogenesis of PD is not yet fully elucidated, accumulating evidence sugg...
Anja T Zai,Corinna Lorenz,Shakana Srikantharajah et al.
Anja T Zai et al.
What exploration strategies do animals use to learn motor skills? Reinforcement learning (RL) theory is a powerful framework to study motor learning, but provides no guidance for estimating motor exploration - the behavioral component aimed...
Preclinical drug screen identifies WEE1 inhibitor and vinca alkaloid as a combination treatment concept for Li-Fraumeni syndrome medulloblastoma [0.03%]
药效筛选识别出WEE1抑制剂与长春花生物碱可作为联合治疗概念用于LFS髓母细胞瘤治疗中
Anna S Kolodziejczak,Florian Selt,Heike Peterziel et al.
Anna S Kolodziejczak et al.
Li-Fraumeni syndrome (LFS) is characterized by constitutional pathogenic TP53 mutation and increased risk of cancer development, including Sonic Hedgehog-activated medulloblastoma (SHH-MB). In LFS patients, radiation and DNA-damaging agents...