Nonspecific ensemble reactivation in mouse dentate gyrus disrupts spatial working memory [0.03%]
小鼠齿状回非特异性联合体反应的破坏作用会影响空间工作记忆
Lucius K Wilmerding,Ivan Kondratyev,Wen Bing Shi et al.
Lucius K Wilmerding et al.
Spatial working memory enables behavioral flexibility and depends upon the hippocampus. The hippocampal dentate gyrus (DG) is hypothesized to act as a pattern separator to disambiguate similar memories. We used activity-dependent labeling s...
Phosphorylation of plectin by Akt3 promotes triple-negative breast cancer cell invasive migration [0.03%]
Akt3对plectin的磷酸化促进三阴性乳腺癌细胞侵袭迁移
Shixue Zheng,Chloe Chan,John M Asara et al.
Shixue Zheng et al.
Triple-negative breast cancer (TNBC) lacks targeted therapeutics and is aggressive with a poor prognosis. The phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway, frequently deregulated in cancers, plays crucial roles in tumorigenesi...
Westerly winds impact glacier energy balance and sublimation at August-one glacier in northern Tibetan Plateau [0.03%]
西风对唐古拉山Augustone冰川的能量平衡和升华的影响研究
Shuhai Guo,Yueping Li,Rensheng Chen et al.
Shuhai Guo et al.
Mid-latitude westerlies critically regulate glacier mass balance on the Tibetan Plateau. Here, we analyze the meteorological variables, surface energy balance (SEB), and surface sublimation of the August-one glacier (located in the northern...
Sparse memory ensembles set brain-wide network states to sustain learned associations [0.03%]
稀疏记忆联合体集合大脑范围内的网络状态以维持学习关联性
Josué Haubrich,Gabriele Russo,Denise Manahan-Vaughan
Josué Haubrich
The ability to recall spatial memories and adapt behavior to changing conditions underlies efficient navigation. These processes are thought to rely on sparse populations of neurons, embedded within distributed brain networks. Here, we soug...
Rotating visual spaces induce behavioral biases consistent with recalibrated heading integration in humans [0.03%]
旋转视觉空间会诱导行为偏差，与人类头部方向再校准整合一致
David G Behery,Diana M Green,Viktor H Klimczyk et al.
David G Behery et al.
Organisms from flies to mice to humans maintain an internal representation of heading by integrating their movements across time. To avoid compounding errors, this integration must be precisely calibrated. Recent evidence from rodents indic...
Alphavirus replicons encoding IFN-γ enhance cancer virotherapy by overcoming macrophage-mediated suppression [0.03%]
携带IFN-γ的 alphavirus 嵌合体复制子能通过克服巨噬细胞介导的抑制来增强癌症病毒疗法
Laura Horvathova,Priscilla Kinderman,Thijs Janzen et al.
Laura Horvathova et al.
Interference by tumor-associated macrophages may significantly reduce the efficacy of therapeutic viruses designed to infect cancer cells and activate anti-tumor T cells. Using a computational model, we hypothesized that viruses encoding a ...
Multicomponent-based analyses of ACS-patient-derived extracellular vesicles as likely tools for tailored interventional approaches [0.03%]
ACS患者衍生的外泌体的多组分分析有望成为特异性治疗方法的有效工具
Saveria Femminò,Alessandro Sarcinella,Alberto Grosso et al.
Saveria Femminò et al.
Reliable predictive biomarkers to reduce unnecessary coronary angiograms (CAGs) in non-ST-segment elevation myocardial infarction (NSTEMI) and unstable angina (UA) patients displaying high-risk features are still lacking. Here, we show that...
A recombinant Cedar virus preclinical model that recapitulates neurological features of henipavirus disease [0.03%]
一种能够再现亨尼帕病毒病神经性特征的Cedar病毒预临床重组模型
Celeste Huaman,Caitlyn Clouse,Madeline Rader et al.
Celeste Huaman et al.
Nipah virus (NiV) and Hendra virus (HeV) are members of the henipavirus genus that cause severe respiratory and/or neurological disease in humans. Because NiV and HeV can only be handled under BSL-4 containment, there are significant practi...
Nucleotide motif-guided selection of plasma microRNA biomarkers in trauma [0.03%]
核苷酸基序指导的创伤患者血浆微小RNA生物标志物的选择
Boyang Ren,Ruoxing Li,Chien-Yu Lin et al.
Boyang Ren et al.
Trauma remains a leading cause of morbidity and mortality in part due to complex pathophysiological responses. Yet our abilities to predict these changes are limited. Plasma miRNAs have been proposed as DAMPs that drive immune response and ...
Jun Liu,Yaxing Feng,Peng Qu et al.
Jun Liu et al.
Cardiac organoids (COs) are platforms for disease modeling and regenerative medicine, yet inadequate vascularization still limits their function and longevity. This review examines how biomaterial properties-porosity, elasticity, surface ch...