Genomic and Epigenomic Signatures Can Distinguish Aggressive Chromophobe Renal Cell Carcinoma from Indolent Renal Oncocytic Tumors in Clinical-grade Samples [0.03%]
基因组和表观基因组标志物可以区分临床样本中的侵袭性肾嫌色细胞癌和良性肾上皮肿瘤
Roberto Ruiz-Cordero,Qi Wang,Gayatri Kumar et al.
Roberto Ruiz-Cordero et al.
Background and objective: Only a minority of renal oncocytic tumors are aggressive. These tumors' behavior is difficult to predict by histopathological evaluation; consequently, many patients experience anxiety upon diagn...
Prostate-specific Antigen and Objective Response Analyses in PROpel: Olaparib Plus Abiraterone Versus Placebo Plus Abiraterone as First-line Therapy for Metastatic Castration-resistant Prostate Cancer [0.03%]
PROpel研究中的前列腺特异性抗原和客观缓解分析：奥拉帕利+阿比特龙对比安慰剂+阿比特龙用于初治转移去势抵抗性前列腺癌患者
Fred Saad,Andrew J Armstrong,Mototsugu Oya et al.
Fred Saad et al.
Background and objective: PROpel (NCT03732820) demonstrated a statistically significant radiographic progression-free survival (rPFS) benefit with olaparib plus abiraterone (Ola + Abi) versus placebo plus abiraterone (P +...
Age-related Efficacy and Safety of Darolutamide Plus Androgen-deprivation Therapy and Docetaxel in Patients with Metastatic Hormone-sensitive Prostate Cancer: A Subgroup Analysis of the Phase 3 ARASENS Trial [0.03%]
达尔鲁单抗联合雄激素剥夺治疗和多西他赛治疗转移性激素敏感型前列腺癌的年龄相关疗效和安全性：Ⅲ期ARASENS试验的一项亚组分析
Joan Carles,Bertrand Tombal,Maha Hussain et al.
Joan Carles et al.
Background and objective: Prostate cancer is typically a disease of older men. As patients age, they develop comorbidities and require more medications, which may adversely affect or be affected by prostate cancer treatme...
A Paradox of Our Time: Evidence-based Guidelines are Blocking Evidence-based Artificial Intelligence [0.03%]
一个时代的悖论：基于证据的指南阻碍了基于证据的人工智能
Vincent Misrai,Alena Bruchon
Vincent Misrai
Artificial intelligence (AI) could help in optimising patient care, but trust and ethical concerns are limiting its clinical adoption. Current practices for reporting of evidence-based guidelines, in terms of a lack of open access and ambig...
Targeted Prostate Health Checks, a Novel Screening System to Identify Men at Risk of Prostate Cancer: Real-world Evidence from More than 18 000 Prostate-specific Antigen Tests [0.03%]
针对前列腺健康的检查项目：一项新的筛查系统，可识别出有罹患前列腺癌风险的男性——来自18,000多项前列腺特异性抗原检测的现实世界证据
Stephen Langley,Santiago Uribe-Lewis,Jennifer Uribe et al.
Stephen Langley et al.
Background and objective: The Targeted Prostate Health Check (TPHC) programme was set up to identify men with prostate cancer (PC) in the Surrey and Sussex region of England that was undetected during the COVID-19 era. We...
Impact of Intravesical Bacillus Calmette-Guérin Therapy Following Transurethral En Bloc Resection of Bladder Tumour: Post Hoc Analysis of a Randomised, Multicentre, Phase 3 Trial [0.03%]
膀胱肿瘤经尿道整块切除术后卡介苗治疗的疗效：随机、多中心 III 期临床试验的事后分析
Jeremy Yuen-Chun Teoh,Chris Ho-Ming Wong,Cheung-Hing Cheng et al.
Jeremy Yuen-Chun Teoh et al.
We conducted a post hoc analysis of the EB-StaR study (NCT02993211) to assess the impact of intravesical bacillus Calmette-Guérin (BCG) therapy following en bloc resection of bladder tumour (ERBT) or standard resection (SR) in patients wit...
Genotype-Phenotype Characterization of Lynch Syndrome-associated Upper Tract Urothelial Carcinoma [0.03%]
林奇综合征相关肾盂尿路上皮癌的基因型表型特征分析
Craig Labbate,Daniel A Igel,Donika Saporito et al.
Craig Labbate et al.
Background and objective: Upper tract urothelial carcinoma (UTUC) is the most prevalent urologic malignancy among patients with Lynch syndrome (LS), which is caused by germline mutations in genes MSH2, MSH6, MLH1, and PMS...
Talazoparib Monotherapy in Metastatic Castration-resistant Prostate Cancer with DNA Damage Response Alterations-Genomic Features Associated with Response to Therapy [0.03%]
用于治疗DNA损伤反应异常的转移性去势抵抗性前列腺癌的 talazoparib 单药疗法-与治疗反应相关的基因组特征
Karim Fizazi,Johann S de Bono,A Douglas Laird et al.
Karim Fizazi et al.
Background and objective: The impact of alterations beyond DNA damage response-homologous recombination repair (DDR-HRR) genes on outcomes with poly(ADP-ribose) polymerase inhibitor monotherapy remains unknown. This study...
Systematic Review of the Definition of Cure and of Curative-intent Treatments in Early Bladder Cancer [0.03%]
早期膀胱癌治愈定义和根治性治疗的系统评价
Félix Guerrero-Ramos,Carsten Schwenke,Álvaro Pinto et al.
Félix Guerrero-Ramos et al.
Background and objective: Current guidelines on bladder cancer lack consensus on which outcomes should be used to define cure, the optimal time point for measurement, and which treatments can be given with curative intent...
Classification of Inaccurate Information About Prostate Cancer on Social Media in English and Spanish [0.03%]
英语和西班牙语前列腺癌社交媒体上不准确信息的分类
Stacy Loeb,Mariana Rangel Camacho,Tatiana Sanchez Nolasco et al.
Stacy Loeb et al.
Inaccurate information about prostate cancer is widespread on online social networks in English and Spanish and spans a variety of topics from prevention and screening to treatment and survivorship. Clinicians should raise awareness that so...