G protein-coupled receptors related to autoimmunity in postural orthostatic tachycardia syndrome [0.03%]
与体位性心动过速综合征自身免疫相关的G蛋白偶联受体研究
Yoko Sunami,Keizo Sugaya,Kazushi Takahashi
Yoko Sunami
Postural orthostatic tachycardia syndrome (POTS) is characterized by exaggerated orthostatic tachycardia in the absence of orthostatic hypotension. The pathophysiology of POTS may involve hypovolemia, autonomic neuropathy, a hyperadrenergic...
Clinical features of flare in Japanese patients with new-onset SLE and risk factors for SLE flare in daily clinical practice: a single-center cohort study [0.03%]
日本新发SLE患者的病情加重临床特征及其日常医疗实践中SLE病情加重的风险因素：单中心队列研究
Shuzo Sato,Shuhei Yoshida,Yuya Sumichika et al.
Shuzo Sato et al.
This study aimed to elucidate the clinical features, outcomes and risk factors of flares in patients with systemic lupus erythematosus (SLE). Data were collected from patients with newly diagnosed SLE at the Fukushima Medical University Hos...
Takemichi Fukasawa,Asako Yoshizaki-Ogawa,Atsushi Enomoto et al.
Takemichi Fukasawa et al.
In recent years, rapid advances in research methods have made single cell analysis possible. Systemic sclerosis (SSc), a disease characterized by the triad of immune abnormalities, fibrosis, and vasculopathy, has also been the subject of va...
Impact of multiple MEFV variants of unknown significance on the diagnosis and clinical presentation of familial Mediterranean fever [0.03%]
MEFV基因多变异体对未知意义的 Familial Mediterranean Fever诊断和临床表现的影响
Dai Kishida,Masahide Yazaki,Akinori Nakamura et al.
Dai Kishida et al.
The detection of variants of unknown significance (VUS) in familial Mediterranean fever (FMF) is common; however, their diagnostic value remains elusive, and the interpretation of multiple VUS remains difficult. Therefore, we examined FMF d...
ARID5B is a negative modulator of IL-6 production in rheumatoid arthritis synovial fibroblasts [0.03%]
ARID5B是类风湿关节炎滑膜成纤维细胞中抑制IL-6产生的调节因子
Yasuhiro Tagawa,Tetsuya Saito,Hideyuki Iwai et al.
Yasuhiro Tagawa et al.
Recent single-cell RNA-sequencing analysis of rheumatoid arthritis (RA) synovial tissues revealed the heterogeneity of RA synovial fibroblasts (SFs) with distinct functions such as high IL-6 production. The molecular mechanisms responsible ...
New-onset of rheumatic diseases following COVID-19 vaccination: the report of three cases and a literature review [0.03%]
COVID-19疫苗接种后新发风湿免疫病3例报道及文献复习
Mayumi Matsuda,Yu Funakubo Asanuma,Kyohei Emoto et al.
Mayumi Matsuda et al.
Vaccines against coronavirus disease 2019 (COVID-19) have been distributed in most countries for the prevention of onset and aggravation of COVID-19. Recently, there have been increasing numbers of reports on new-onset autoimmune and autoin...
Fatal hemophagocytic lymphohistiocytosis with intravascular large B-cell lymphoma following coronavirus disease 2019 vaccination in a patient with systemic lupus erythematosus: an intertwined case [0.03%]
一名系统性红斑狼疮患者在接种新型冠状病毒疫苗后出现噬血细胞综合征伴血管内大B细胞淋巴瘤的交织病例报告
Yusuke Ueda,Tomoyuki Sakai,Kazunori Yamada et al.
Yusuke Ueda et al.
Hemophagocytic lymphohistiocytosis (HLH) has been recognized as a rare adverse event following the coronavirus disease 2019 (COVID-19) vaccination. We report a case of neuropsychiatric symptoms and refractory HLH in a woman with systemic lu...
Evolution of diagnostic criteria and new insights into clinical testing in mixed connective tissue disease; anti-survival motor neuron complex antibody as a novel marker of severity of the disease [0.03%]
混合结缔组织病诊断标准的演变及新的临床检测见解；反生存电机神经元复合抗体作为疾病严重程度的新标志物
Satoshi Kubo,Yoshiya Tanaka
Satoshi Kubo
Mixed connective tissue disease (MCTD) is an autoimmune disorder characterized by a combination of clinical features from systemic lupus erythematosus, systemic sclerosis, and inflammatory muscle disease, along with the presence of positive...
Successful high-dose glucocorticoid therapy for anti-mitochondrial antibody-positive myocarditis arising during tocilizumab and low-dose glucocorticoid therapy for rheumatoid arthritis [0.03%]
托珠单抗和小剂量糖皮质激素治疗风湿性关节炎期间出现的抗线粒体抗体阳性的暴发性心肌炎成功应用大剂量糖皮质激素治疗1例报告
Koji Suzuki,Mitsuhiro Akiyama,Shuntaro Saito et al.
Koji Suzuki et al.
Anti-mitochondrial antibody (AMA)-positive myopathy, a recently identified condition with significant cardiac involvement, poses a serious challenge in treatment consensus due to its extreme rarity. While several studies demonstrate the eff...
Successful treatment with tofacitinib for anti-melanoma differentiation-associated gene 5 antibody-positive juvenile dermatomyositis: case reports and review of the literature [0.03%]
托法替尼治疗抗MDA5抗体阳性青少年皮肌炎成功病例报告及文献复习
Susumu Yamazaki,Masaki Shimizu,Ayane Yakabe et al.
Susumu Yamazaki et al.
Although the clinical efficacy of tofacitinib has been reported in adult patients with anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive (Ab+) dermatomyositis, data on its use in refractory juvenile dermatomyositis (J...