Hiroyuki Takahashi,Daibo Kojima,Masato Watanabe
Hiroyuki Takahashi
Trained immunity (TI) is functional memory displayed by innate immune cells (IICs). TI facilitates rapid, non-specific responses to pathogens upon secondary challenge. It is driven by immunological signaling and metabolic rewriting via epig...
Clinical profile of IgG4-related disease in Japan based on the rare disease data registry [0.03%]
基于罕见病登记的数据资料分析日本IgG4相关疾病患者的临床特征
Motohisa Yamamoto,Masatoshi Kanda,Ichiro Mizushima et al.
Motohisa Yamamoto et al.
We started a registry for cases of immunoglobulin (Ig)G4-related disease (IgG4-RD) in December 2019 to clarify the clinical profile of IgG4-RD. In this study, clinical information from 854 cases registered by February 16, 2024 was analyzed ...
Expansion of granulocyte-macrophage colony-stimulating factor producing CD4+ T cells in an animal model with enhanced interleukin-1 signal [0.03%]
一种增强型白细胞介素-1信号动物模型中CD4⁺T细胞增殖的扩大及产生粒细胞-巨噬细胞集落刺激因子的影响研究
Sho Ishigaki,Keiko Yoshimoto,Mitsuhiro Akiyama et al.
Sho Ishigaki et al.
Interleukin-1, a pro-inflammatory cytokine, plays a crucial role in inflammatory disease pathogenesis. Interleukin-1 receptor antagonist knockout (IL-1Ra KO) mice spontaneously develop aortitis, arthritis and dermatitis, and are employed as...
Analysis of musculoskeletal ultrasound findings and cytokines/growth factors in glucocorticoid-resistant polymyalgia rheumatica [0.03%]
糖皮质激素抵抗性多肌炎的肌肉骨骼超声表现和细胞因子/生长因子分析
Tomoki Origuchi,Masataka Umeda,Shoichi Fukui et al.
Tomoki Origuchi et al.
We sought to clarify the musculoskeletal ultrasound (MSUS) findings and serum concentrations of cytokines/growth factors in glucocorticoid-resistant polymyalgia rheumatica (GC-R PMR). Patients with PMR admitted to Nagasaki University Hospit...
Increased response to granulocyte-macrophage colony-stimulating factor in peripheral blood cells and transient manifestations mimicking juvenile myelomonocytic leukemia in a male patient with NEMO deficiency caused by a deep intronic pathogenic variant of IKBKG [0.03%]
NEMO缺陷（由IKBKG内含子致病突变引起）男性患者外周血细胞对粒细胞-巨噬细胞集落刺激因子反应增强及短暂表现模仿 juvenile myelomonocytic leukemia 的表型研究
Masahiro Ueki,Shinsuke Hirabayashi,Yoshitaka Honda et al.
Masahiro Ueki et al.
X-linked NF-κB essential modulator (NEMO) deficiency is a primary immunodeficiency characterized by combined immunodeficiency and ectodermal dysplasia. Monocytes from the patients demonstrate a severely impaired response to tissue necrosis...
Autonomic disorder in systemic lupus erythematosus: autoimmune autonomic ganglionopathy [0.03%]
系统性红斑狼疮的自主神经异常：自身免疫性自主神经节病
Naoto Azuma,Mai Nakano,Masao Tamura et al.
Naoto Azuma et al.
The pathomechanisms of autonomic disorders in systemic lupus erythematosus (SLE) remain unclear. We herein report a patient with SLE who developed autonomic disorders presumably caused by autoimmune autonomic ganglionopathy (AAG). A 42-year...
Sakae Kumasaka,Yasuyuki Negishi,Rimpei Morita et al.
Sakae Kumasaka et al.
Zinc (Zn), an essential trace element, plays a significant role in fetal development and biological defense during the embryonic and neonatal periods. Therefore, exploring the kinetics of Zn related to immune disturbances in preterm neonate...
Investigating the impact of tocilizumab on serum cytokines concentrations in Japanese FMF patients: a sub-analysis of the NUH01FMF study [0.03%]
托珠单抗对日本周期热患者血清细胞因子浓度影响的研究：NUH01FMF研究的亚组分析
Tomohiro Koga,Shuntaro Sato,Kaori Furukawa et al.
Tomohiro Koga et al.
Familial Mediterranean Fever (FMF) is the most common hereditary autoinflammatory disease, characterized by recurrent fever, arthritis, rash, and serositis, and is caused by mutations in the MEFV gene coding for the pyrin protein. The prima...
Myositis-specific and myositis-associated autoantibodies: their clinical characteristics and potential pathogenic roles [0.03%]
肌炎特异性和平共处自身抗体：临床特征及其潜在的病理作用
Mariko Ogawa-Momohara,Yoshinao Muro
Mariko Ogawa-Momohara
In recent years, various myositis-specific and myositis-associated autoantibodies have been identified in idiopathic inflammatory myopathies, including dermatomyositis (DM), anti-synthetase syndrome (ASS), immune-mediated necrotizing myopat...
The roles of glioma-associated macrophages/microglia and potential targets for anti-glioma therapy [0.03%]
胶质瘤相关巨噬细胞/小胶质细胞的功能及潜在抗肿瘤治疗靶点研究进展
Hiroaki Matsuzaki,Cheng Pan,Yoshihiro Komohara et al.
Hiroaki Matsuzaki et al.
Glioblastoma (GBM) is the central nervous system tumor with the most aggressive behavior, and no definitive therapy has yet been found. The tumor microenvironment of GBM is immunosuppressive and is considered a 'cold tumor' with low lymphoc...