Large-scale cross-trait genetic analysis highlights shared genetic backgrounds of autoimmune diseases [0.03%]
大规模跨性状遗传分析揭示自身免疫性疾病共有的遗传背景
Yuji Yamamoto,Yuya Shirai,Ryuya Edahiro et al.
Yuji Yamamoto et al.
Disorders associated with the immune system burden multiple organs, although the shared biology exists across the diseases. Preceding family-based studies reveal that immune diseases are heritable to varying degrees, providing the basis for...
Differences in immunological profile in atopic dermatitis patients with and without dupilumab therapy [0.03%]
Dupixent治疗与非Dupixent治疗的特应性皮炎患者的免疫学特征差异分析
Jarmila Čelakovská,Eva Čermáková,Petra Boudková et al.
Jarmila Čelakovská et al.
Our aim is to determine the number of leukocytes, T lymphocytes and B lymphocytes and the expression of activation markers CD200 and CD23 on B lymphocytes in atopic dermatitis (AD) patients (treated and not treated with dupilumab) during th...
Unraveling immune cell heterogeneity in autoimmune arthritis: insights from single-cell RNA sequencing [0.03%]
单细胞RNA测序解析自身免疫性关节炎的免疫细胞异质性及其新见解
Sotaro Nakajima,Haruka Tsuchiya,Keishi Fujio
Sotaro Nakajima
Single-cell RNA sequencing (scRNA-seq) has transformed our understanding of immune-mediated arthritis, which comprises rheumatoid arthritis and spondyloarthritis. This review outlines the key findings and advancements in scRNA-seq studies f...
Successful maintenance therapy with tocilizumab for severe acute liver failure associated with adult-onset still's disease [0.03%]
托珠单抗成功治疗成人 Still 病并发急性重症肝功能衰竭病例报告
Koji Suzuki,Mitsuhiro Akiyama,Yukie Nakadai et al.
Koji Suzuki et al.
Elevated liver enzymes are commonly observed among adult-onset Still's disease (AOSD), but severe acute liver failure is extremely rare. Although severe acute liver failure associated with AOSD poses a life-threatening condition, the approp...
Activation of bystander CD8+ T cells in a pediatric patient with acute hepatitis E [0.03%]
一名急性感染戊型肝炎患儿旁观者CD8⁺T细胞的活化
Atsushi Morita,Kazuo Imagawa,Tomoya Iwasaki et al.
Atsushi Morita et al.
Most children with acute hepatitis A virus (HAV) or hepatitis E virus (HEV) infection are asymptomatic. Bystander CD8+ T-cell activation has garnered attention owing to its possible pathophysiological role in adult hepatitis. However, no re...
Double-filtration plasmapheresis reduces type I interferon bioavailability and inducing activity in systemic lupus erythematosus [0.03%]
双重滤过血浆置换降低系统性红斑狼疮患者I型干扰素的生物利用度和诱导活性
Takumi Saito,Ryo Takatsuji,Goh Murayama et al.
Takumi Saito et al.
Type I interferons (IFN-Is) play a significant role in systemic lupus erythematosus (SLE) pathogenesis. Double-filtration plasmapheresis (DFPP) is a treatment option for SLE; however, its effect on IFN-Is remains unclear. Therefore, we inve...
Herpes zoster in the context of immune reconstitution inflammatory syndrome in patients with rheumatic diseases: a single-center retrospective study [0.03%]
风湿性疾病患者免疫重建炎症综合征背景下带状疱疹的病例研究——单中心回顾性研究
Keisuke Maeshima
Keisuke Maeshima
Immune reconstitution inflammatory syndrome (IRIS) experienced in rheumatology practice is diverse and includes opportunistic infections such as herpes zoster (HZ). This study aimed to explore the risk of HZ in patients with rheumatic disea...
Low serum complements in idiopathic inflammatory myositis: clinical features and impact on the prognosis [0.03%]
特发性炎性肌病低补体血症的临床特征及其对预后的影响
Shun Nomura,Yasuhiro Shimojima,Dai Kishida et al.
Shun Nomura et al.
This study investigated the clinical features and prognostic relevance of decreased serum complement levels in patients with idiopathic inflammatory myositis (IIM). The clinical information of IIM patients with less than normal serum comple...
Idiopathic pulmonary hemosiderosis associated with Kabuki syndrome [0.03%]
与 Kabuki 综合征相关的特发性肺嗜酸性粒细胞肺炎伴血行侧支循环
Yoji Uejima,Kenji Yoshida,Hirofumi Ohashi
Yoji Uejima
Kabuki syndrome (KS) is a genetic disorder caused by gene mutations in either lysine-specific methyltransferase 2D (KMT2D) or lysine demethylase 6A (KDM6A). This congenital disorder exhibits characteristic facial features, developmental del...
Comparative analysis of renal decline rates in microscopic polyangiitis: unveiling the slowly progressive phenotype [0.03%]
显微镜多血管炎肾损害进展速度的比较分析：揭示缓慢进展表型
Kanako Tsutsumi,Narumichi Iwamura,Katsumi Eguchi et al.
Kanako Tsutsumi et al.
Although rapidly progressive glomerulonephritis (RPGN) is the main renal phenotype of microscopic polyangiitis (MPA), we aim to clarify the clinical features of slowly progressive MPA. This retrospective observational study included 12 pati...