The role of TRECs/KRECs as immune indicators that reflect immunophenotypes and predict the risk of infection in systemic autoimmune diseases [0.03%]
TRECS/KRECs作为反映免疫表型和预测自身免疫病感染风险的免疫标志物的作用
Takuji Itakura,Hirokazu Sasaki,Tadashi Hosoya et al.
Takuji Itakura et al.
T cell receptor rearrangement excision circles (TRECs) and immunoglobulin κ-deleting recombination excision circles (KRECs) represent the lymphopoiesis capacity, widely used for newborn screening of inborn errors of immunity. To clarify th...
Chronic kidney disease and inflammatory cytokines in rheumatoid arthritis: a potential pathogenic link [0.03%]
慢性肾病与类风湿关节炎炎症细胞因子之间的潜在致病联系
Hironari Hanaoka,Takumi Aoki,Taiji Kosaka et al.
Hironari Hanaoka et al.
Recent evidence indicates an increased risk of chronic kidney disease (CKD) in patients with rheumatoid arthritis (RA), with prevalence rates ranging from 20.8% to 24.5%. Risk factors for CKD among RA patients include advancing age, diabete...
Hiromitsu Asashima,Satoshi Akao,Isao Matsumoto
Hiromitsu Asashima
Immune checkpoint molecules, including both co-inhibitory molecules and co-stimulatory molecules, are known to play critical roles in regulating T-cell responses. During the last decades, immunotherapies targeting these molecules (such as p...
Effectiveness for remission maintenance rate and safety of different rituximab regimens for treating anti-neutrophil cytoplasmic antibody-associated vasculitis in Japan: a J-CANVAS study [0.03%]
日本J-CANVAS研究：不同利妥昔单抗维持方案治疗ANCA相关性血管炎的疗效和安全性比较研究
Chie Ogita,Kazuteru Noguchi,Jiro Takeuchi et al.
Chie Ogita et al.
Rituximab (RTX) has been reported to effectively maintain remission in anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV). In this multicenter study involving 57 patients who achieved remission after 24 weeks, we evaluated the...
Additional benefits of belimumab in chronic phase of systemic lupus erythematosus and efficacy of tacrolimus combination therapy [0.03%]
贝利木单抗治疗系统性红斑狼疮慢性期的额外疗效及与他克莫司联合用药的有效性分析
Satoshi Suzuki,Tomoya Otani,Keigo Ikeda et al.
Satoshi Suzuki et al.
Systemic lupus erythematosus (SLE) is a typical autoimmune disease; although severe disease and refractoriness to existing therapies are still experienced, the number of cases resistant to remission induction has decreased with the establis...
Pyoderma gangrenosum arising at the site of BCG immunization in a nine-month-old girl [0.03%]
一名9个月婴儿在卡介苗接种部位出现坏死性瘭疽样脓皮病
Yuka Okura,Yasuyoshi Hiramatsu,Masaki Shimomura et al.
Yuka Okura et al.
Pyoderma gangrenosum (PG) is an extremely rare disorder in children. We report a nine-month-old girl with PG who presented with high-grade fever and rapidly progressive ulcers at the site of a Bacillus Calmette-Guérin (BCG) inoculation 2 m...
A novel frameshift mutation in ADCK1 identified in a case of chronic fatigue syndrome successfully treated with oral 5-ALA/SFC [0.03%]
ADCK1的新移码突变在慢性疲劳综合征中的案例报告：口服5-ALA/SFC成功治疗
Tomohiro Koga,Kiyoshi Kita,Junko Okumura et al.
Tomohiro Koga et al.
Chronic Fatigue Syndrome (CFS) is a complex disorder characterized by prolonged, unexplained fatigue and challenging diagnosis. We report the case of a 35-year-old Japanese woman with CFS who had experienced chronic fatigue since the age of...
Hiroyuki Takahashi,Daibo Kojima,Masato Watanabe
Hiroyuki Takahashi
Trained immunity (TI) is functional memory displayed by innate immune cells (IICs). TI facilitates rapid, non-specific responses to pathogens upon secondary challenge. It is driven by immunological signaling and metabolic rewriting via epig...
Clinical profile of IgG4-related disease in Japan based on the rare disease data registry [0.03%]
基于罕见病登记的数据资料分析日本IgG4相关疾病患者的临床特征
Motohisa Yamamoto,Masatoshi Kanda,Ichiro Mizushima et al.
Motohisa Yamamoto et al.
We started a registry for cases of immunoglobulin (Ig)G4-related disease (IgG4-RD) in December 2019 to clarify the clinical profile of IgG4-RD. In this study, clinical information from 854 cases registered by February 16, 2024 was analyzed ...
Expansion of granulocyte-macrophage colony-stimulating factor producing CD4+ T cells in an animal model with enhanced interleukin-1 signal [0.03%]
一种增强型白细胞介素-1信号动物模型中CD4⁺T细胞增殖的扩大及产生粒细胞-巨噬细胞集落刺激因子的影响研究
Sho Ishigaki,Keiko Yoshimoto,Mitsuhiro Akiyama et al.
Sho Ishigaki et al.
Interleukin-1, a pro-inflammatory cytokine, plays a crucial role in inflammatory disease pathogenesis. Interleukin-1 receptor antagonist knockout (IL-1Ra KO) mice spontaneously develop aortitis, arthritis and dermatitis, and are employed as...