Rapid response of eculizumab: a rescue therapy for ventilator-dependent refractory myasthenic crisis [0.03%]
艾库珠单抗快速起效：依赖呼吸机的重症肌无力急性发作的补救治疗
Yohei Takenobu,Kazutoshi Ikeda,Sachiko Hasebe et al.
Yohei Takenobu et al.
Myasthenic crisis (MC) represents the most severe and life-threatening complication of myasthenia gravis (MG). Some patients exhibit refractory responses to conventional immunotherapies, including intravenous immunoglobulin and plasma excha...
Causal association of immune-related genes with mouth ulcers: findings from summary-based Mendelian randomization and transcriptome-wide association analysis [0.03%]
基于汇总数据的孟德尔随机化和转录组范围关联分析确定口腔溃疡相关的免疫相关基因因果关系
Mengru Shi,Tianqi Wang,Qi Xie et al.
Mengru Shi et al.
Oral ulceration is the most common ulcerative condition in humans, yet its underlying etiology remains poorly understood. To identify potential causal genes involved in the pathogenesis of mouth ulcers, we applied summary data-based Mendeli...
Anti-cytokine autoantibodies in human susceptibility to infectious diseases: insights from Inborn errors of immunity [0.03%]
人类感染性疾病易感性的抗细胞因子自身抗体：来自先天性免疫缺陷的启示
Kosuke Noma,Takaki Asano,Maki Taniguchi et al.
Kosuke Noma et al.
The study of Inborn Errors of Immunity (IEIs) is critical for understanding the complex mechanisms of the human immune response to infectious diseases. Specific IEIs, characterized by selective susceptibility to certain pathogens, have enha...
Bibliometric analysis of systemic lupus erythematosus during pregnancy from 2003 to 2024 [0.03%]
2003年至2024年孕期系统性红斑狼疮的计量学分析
Xinyan Zou,Xinfu Zou,Qiaoqiao Liu et al.
Xinyan Zou et al.
Autoimmune diseases such as systemic lupus erythematosus (SLE) and antiphospholipid antibody syndrome have a significant impact on pregnancy, potentially exacerbating SLE symptoms and leading to miscarriage, pre-eclampsia and other pregnanc...
Systemic sclerosis presenting TAFRO syndrome-like manifestations including renal glomerular microangiopathy: a case report and literature review [0.03%]
伴有肾系膜微血管病变的系统性硬化症一例及其文献复习
Hiroyuki Kawahara,Satoshi Hara,Noriko Iwaki et al.
Hiroyuki Kawahara et al.
TAFRO syndrome is a systemic inflammatory disorder of unknown etiology, and its diagnosis requires the exclusion of autoimmune diseases. A 42-year-old Japanese woman presented with TAFRO syndrome-like manifestations, but had undiagnosed lim...
Overlapping Aicardi-Goutières and Singleton-Merten syndromes with a heterozygous gain-of-function mutation in IFIH1 mimicking juvenile idiopathic arthritis [0.03%]
重叠的Aicardi-Goutières和Singleton-Merten综合症，IFIH1基因杂合激活性突变，模拟幼年特发性关节炎
Susumu Yamazaki,Shuya Kaneko,Asami Shimbo et al.
Susumu Yamazaki et al.
Aicardi-Goutières syndrome (AGS) and Singleton-Merten syndrome (SMS) are associated with heterozygous gain-of-function mutations in the interferon induced with helicase C domain 1 (IFIH1) gene. Recent reports describe patients exhibiting o...
When ocular surface treatment fails: exploring neuropathic ocular pain in aqueous-deficient dry eye due to Sjögren's syndrome treated with mirogabalin: a case study [0.03%]
当眼表治疗失败时：米罗加必利治疗干燥综合症所致的无水干眼病神经病理性眼痛的病例研究探索
Yoshiaki Tagawa,Yusuke Aihara,Susumu Ishida
Yoshiaki Tagawa
Dry eye disease can be classified as aqueous-deficient, evaporative and mixed-type. Recently, neuropathic pain has been indicated to be involved in the subjective symptoms of aqueous-deficient dry eye. However, the mechanism underlying neur...
Advances in understanding the role and mechanism of the cGAS-STING signaling pathway in ocular diseases [0.03%]
cGAS-STING信号通路在眼病中作用及机制的研究进展
MengDi Zhang,Jiayu Xu,Wenjia Qu et al.
MengDi Zhang et al.
The cGAS-STING signaling pathway plays a critical role in the immune defense against DNA viruses and in autoimmunity, coordinating a cascade of events that enhance cytokine production, particularly type I interferons. This review summarizes...
Pathogenesis and detection methods of anti-acetylcholine receptor antibodies in myasthenia gravis [0.03%]
抗乙酰胆碱受体抗体在重症肌无力发病机制及检测方法中的作用
Shigeaki Suzuki
Shigeaki Suzuki
Myasthenia gravis (MG), which affects the endplate region of the postsynaptic neuromuscular junction, is the best-understood autoimmune disease. MG is driven by anti-acetylcholine receptor (AChR) or muscle-specific receptor tyrosine kinase,...
Recent advances in clinical and pathological significance of autoantibodies [0.03%]
自身抗体临床和病理意义的研究进展
Masataka Kuwana
Masataka Kuwana