Factors related to seroconversion of anti-cyclic citrullinated peptide antibody after the onset of rheumatoid arthritis: a case-control study and systematic review [0.03%]
抗环瓜氨酸肽抗体阳性在类风湿关节炎发病后转阴的相关因素：病例对照研究和系统评价
Yui Kosumi,Ryoko Asano,Aki Sugano et al.
Yui Kosumi et al.
Anti-cyclic citrullinated peptide (CCP) antibodies typically present before rheumatoid arthritis (RA) but appear (seroconvert) after disease onset in some patients. This study analyzed factors related to anti-CCP seroconversion. Fifty-six c...
Clinical improvement of salt-and-pepper skin changes in juvenile systemic sclerosis using mycophenolate mofetil after intravenous methylprednisolone: a 3-year follow-up [0.03%]
静脉注射甲基泼尼松龙后使用霉酚酸酯治疗青少年系统性硬化症的“盐和胡椒”皮疹改善：为期三年的随访
Daisuke Hironaka,Hiroyuki Wakiguchi,Fumiko Okazaki et al.
Daisuke Hironaka et al.
In adult systemic sclerosis (SSc), salt-and-pepper skin changes can be used to diagnose diffuse cutaneous SSc during the early stages. However, reports of juvenile SSc (JSSc) with salt-and-pepper skin changes are unavailable. A 12-year-old ...
Effect of organism aging on the development of anti-PD-(L)1 therapy-associated adverse events [0.03%]
衰老对PD-(L)1抑制剂相关免疫不良事件发生发展的影响研究
Hirotake Tsukamoto,Kosaku Murakami,Yuji Miura et al.
Hirotake Tsukamoto et al.
Immune checkpoint inhibitor (ICI)-mediated release of immune suppression involves the risk of (re)activating the immune responses to self-tissues, which are considered 'side effects' of this therapy, immune-related adverse events (irAEs). A...
A new era in atopic dermatitis treatment and evolving therapeutic strategies [0.03%]
特应性皮炎治疗的新纪元及疗法的演变
Tetsuya Honda
Tetsuya Honda
Atopic dermatitis (AD) is a common chronic inflammatory skin disorder whose pathophysiology remained poorly understood until recently. For decades, treatment relied primarily on topical corticosteroids, with no therapies specifically target...
Mechanisms of T cell-mediated immune evasion in cervical cancer: a comprehensive bibliometric analysis and future research directions [0.03%]
宫颈癌T细胞介导的免疫逃逸机制：全面文献计量分析及未来研究方向
Xue Bai,Hongxia Wang,Qianyu Guo
Xue Bai
Cervical cancer, a prevalent malignancy caused by high-risk HPV strains, remains a significant challenge due to its ability to evade the immune system, particularly T cell-mediated responses. This study aims to explore the research landscap...
Life-threatening refractory leukopenia in a patient with systemic lupus erythematosus successfully treated with rituximab [0.03%]
难治性白细胞减少危及生命的系统性红斑狼疮患者利妥昔单抗治疗成功病例报告
Shunichiro Hanai,Yoshiaki Kobayashi,Daiki Nakagomi
Shunichiro Hanai
Leukopenia can occur because of lymphopenia, neutropenia or both. Leukopenia appearing as a common hematological manifestation of systemic lupus erythematosus (SLE) is typically mild, but potentially life-threatening. However, no consensus ...
Macrophage activation syndrome associated with multi-system inflammatory syndrome in children: a case report and cytokine profile [0.03%]
与儿童多系统炎症综合征相关的巨噬细胞活化综合征1例及细胞因子谱分析
Yuji Fujita,Masaki Shimizu,Sayaka Aihara et al.
Yuji Fujita et al.
Macrophage activation syndrome (MAS) is a potentially life-threatening complication requiring early diagnosis and prompt treatment in rheumatic diseases such as systemic juvenile idiopathic arthritis (sJIA). Recently, multisystem inflammato...
Comparison of drug retention rates between TNF inhibitors and tocilizumab for Takayasu arteritis: a multicenter retrospective study [0.03%]
英夫利昔单抗与托珠单抗治疗大动脉炎疗效的多中心回顾性研究
Takahiro Sugiyama,Shunsuke Furuta,Taro Iwamoto et al.
Takahiro Sugiyama et al.
Objective: We compared the drug retention rate of tumor necrosis factor (TNF) inhibitors (TNFi) and tocilizumab in Takayasu arteritis (TAK) as an index of balance between effectiveness and safety in a real-world setting. ...
The significance of tumor microenvironment for immunotherapy in melanoma and non-melanoma skin cancer [0.03%]
皮肤肿瘤免疫治疗中微环境的意义研究
Taku Fujimura
Taku Fujimura
Immune checkpoint inhibitors (ICIs), such as anti-PD-1 antibody, have significantly changed the treatment landscape not only for unresectable melanoma but also for non-melanoma skin cancers. In addition, anti-PD-1 antibody administration me...
Successful tocilizumab monotherapy for multicentric Castleman disease complicated by rheumatoid arthritis and Sjögren's disease: a case-based literature review [0.03%]
利妥昔单抗联合环磷酰胺治疗复发性弥漫大B细胞淋巴瘤的疗效观察及文献复习
Koji Suzuki,Mitsuhiro Akiyama,Koichi Saito et al.
Koji Suzuki et al.
Multicentric Castleman disease (MCD) is a rare and complex lymphoproliferative disorder marked by multiple lymph node enlargement, characteristic histopathological features, and systemic inflammation driven by excessive interleukin-6 (IL-6)...