Efficacy of infliximab as a switched biologic in rheumatoid arthritis patients in daily clinical practice [0.03%]
在日常临床实践中，英夫利昔单抗作为改善类风湿关节炎患者病情的换用生物制剂的疗效研究
Masataka Umeda,Tomohiro Koga,Kunihiro Ichinose et al.
Masataka Umeda et al.
To assess the efficacy and safety of switching to infliximab (IFX) from other biological disease-modifying anti-rheumatic drugs (bDMARDs) among Japanese patients with rheumatoid arthritis (RA) in daily practice. We examined 24 consecutive R...
Hirokazu Kanegane
Hirokazu Kanegane
Recent advances in molecular biology have provided important insights into the genetic background of various inflammatory diseases. In particular, genome-wide association studies of inflammatory diseases have revealed genetic loci that play...
Gyohei Egawa
Gyohei Egawa
The skin is outermost barrier of the body and protects us from various kinds of external stimuli. The barrier function of the skin is, however, not wholly perfect but include some 'security holes' where external antigen invades in. Further,...
Successful treatment with tacrolimus of refractory pyoderma gangrenosum with pouchitis after restorative proctocolectomy for ulcerative colitis [0.03%]
溃疡性结肠炎回肠储袋肛管吻合术后难治性坏死性脓皮病伴储袋黏膜炎 tacrolimus 治愈1例报告
Miwa Satake,Hirotake Sakuraba,Hiroto Hiraga et al.
Miwa Satake et al.
We describe herein a case of severe relapsed pyoderma gangrenosum (PG) concomitantly with severe pouchitis treated by tacrolimus. A 25-year-old woman had undergone proctocolectomy with construction of ileo-anal pouch surgery for refractory ...
Prediction of therapeutic responses with ultrasonography in RA patients treated with an anti-TNF drug: a retrospective cohort study [0.03%]
抗肿瘤坏死因子药物治疗的类风湿关节炎患者超声波疗效预测：回顾性队列研究
Yuji Nozaki,Jinhai Ri,Kenji Sakai et al.
Yuji Nozaki et al.
Objective: Ultrasound (US) is more sensitive and reliable than a clinical examination, and is better correlated with the disease activity in rheumatoid arthritis (RA). We conducted the present study to assess the value of...
Disease modeling of immunological disorders using induced pluripotent stem cells [0.03%]
利用诱导多能干细胞进行免疫性疾病建模
Megumu K Saito
Megumu K Saito
Disease-associated induced pluripotent stem cells (iPSCs) established from patients are now widely used for disease modeling. They can provide an unlimited source of hematopoietic cells that carry the patients' genetic background, making th...
Characteristic TARC/CCL17 expression in the salivary gland of IgG4-related disease: potential diagnostic utility and insights into pathogenesis [0.03%]
IgG4相关性疾病腮腺组织TARC(CCL17)表达的特征性改变及其诊断和病理意义研究
Immunoglobulin G4-related disease (IgG4-RD) is a chronic inflammatory condition of unknown etiology characterized by lymphocytic infiltration, fibrosis, and infiltration of IgG4-positive plasma cells. It affects various organs, including th...