Neuropsychiatric manifestations in systemic lupus erythematosus and antiphospholipid syndrome: pathophysiology and current insights [0.03%]
系统性红斑狼疮和抗磷脂综合征的精神神经表现：病理生理及最新认识
Yuichiro Fujieda
Yuichiro Fujieda
Neuropsychiatric manifestations in systemic lupus erythematosus (SLE) and anti-phospholipid syndrome (APS) represent complex clinical challenges due to their diverse presentations and multifactorial pathogenesis. Neuropsychiatric SLE (NPSLE...
Drug retention rate of Janus kinase inhibitors in patients with rheumatoid arthritis: the KEIO-RA cohort study [0.03%]
日本Keio大学风湿病队列研究：雅美罗治疗类风湿关节炎患者的药物留存率
Satoshi Takanashi,Masatoshi Kawai,Mitsuhiro Akiyama et al.
Satoshi Takanashi et al.
This study aimed to investigate the effectiveness and safety of Janus kinase inhibitors (JAKis) in patients with rheumatoid arthritis (RA) in the real world. All consecutive patients with RA from the KEIO-RA cohort who had received a JAKi f...
The role of immunoglobulin E in upper respiratory allergies: mechanisms and therapeutic strategies [0.03%]
免疫球蛋白E在上呼吸道过敏中的作用：机制与治疗策略
Shiji Li,Jingyun Li,Yuan Zhang et al.
Shiji Li et al.
This review focuses on the central role of Immunoglobulin E (IgE) in upper respiratory allergic diseases and associated therapeutic strategies. As the core immunoglobulin driving type 2 inflammation, IgE production is meticulously regulated...
Successful treatment of tofacitinib-refractory scleritis associated with multiple systemic inflammatory diseases using upadacitinib [0.03%]
乌帕替尼成功治疗托法替布无效的伴多种系统性炎症疾病的巩膜炎患者
Kodai Yuge,Nobuyo Yawata,Kenichiro Asahara et al.
Kodai Yuge et al.
Scleritis is often associated with systemic inflammatory diseases, and a subset of patients remains refractory to conventional therapies, including corticosteroids, immunosuppressants, and tumor necrosis factor inhibitors (TNFi). Janus kina...
Rozanolixizumab as rescue therapy in triple-seronegative refractory generalized myasthenia gravis [0.03%]
针对难治性全身型重症肌无力的三阴性患者使用Rozanolixizumab治疗的研究
Yohei Takenobu,Takayuki Kikuchi,Daiki Ishikawa et al.
Yohei Takenobu et al.
Myasthenia gravis (MG) is an autoimmune disease affecting the neuromuscular junction, most commonly associated with anti-acetylcholine receptor antibodies, less frequently with muscle-specific kinase antibodies, and occasionally with low-de...
Cutaneous sarcoidosis following complete remission of diffuse large B-cell lymphoma: a case report and literature review [0.03%]
弥漫性大B细胞淋巴瘤完全缓解后的皮肤结节病一例报告及文献复习
Shuhei Yoshida,Jumpei Temmoku,Kenji Saito et al.
Shuhei Yoshida et al.
Sarcoidosis is a multi-systemic granulomatous disease of unknown etiology. Its association with lymphoproliferative disorders is termed sarcoidosis-lymphoma syndrome, which is typically characterized by sarcoidosis preceding lymphoma. Howev...
Long COVID: mechanisms of disease, multisystem sequelae, and prospects for treatment [0.03%]
长新冠肺炎：疾病机制、多系统后遗症及治疗前景
Seiya Oba,Tadashi Hosoya,Hideyuki Iwai et al.
Seiya Oba et al.
Long COVID has emerged as a significant global health issue, affecting individuals across a wide spectrum of initial disease severity. While its definition and prevalence vary across studies, persistent symptoms such as fatigue, cognitive d...
Takuma Koga,Shinjiro Kaieda,Makiko Ebuchi et al.
Takuma Koga et al.
A 68-year-old Japanese woman was diagnosed with palmoplantar pustulosis. She presented with anterior chest pain and swelling, as well as pain in the right first finger. Initially, antibiotics was ineffective, the patient was diagnosed with ...
Updates on the pathogenesis and molecular-targeted therapies of Still's disease [0.03%]
Still病的发病机制和分子靶向治疗研究进展
Koji Suzuki,Yuko Kaneko
Koji Suzuki
Still's disease is a systemic inflammatory disorder involving both innate and adaptive immunity. Although its pathogenesis remains incompletely understood, immune cells such as neutrophils, macrophages, and T cells, along with pro-inflammat...
Factors related to seroconversion of anti-cyclic citrullinated peptide antibody after the onset of rheumatoid arthritis: a case-control study and systematic review [0.03%]
抗环瓜氨酸肽抗体阳性在类风湿关节炎发病后转阴的相关因素：病例对照研究和系统评价
Yui Kosumi,Ryoko Asano,Aki Sugano et al.
Yui Kosumi et al.
Anti-cyclic citrullinated peptide (CCP) antibodies typically present before rheumatoid arthritis (RA) but appear (seroconvert) after disease onset in some patients. This study analyzed factors related to anti-CCP seroconversion. Fifty-six c...