Establishment of novel cell lines that maintain the features of B cells derived from patients with neuromyelitis optica spectrum disorder [0.03%]
建立新型细胞系以维持神经谱系疾病患者的B细胞特征
Shuhei Sano,Soichiro Yoshikawa,Yasunobu Hoshino et al.
Shuhei Sano et al.
B cells that produce anti-aquaporin-4 (AQP4) antibodies play a crucial role in neuromyelitis optica spectrum disorder (NMOSD) pathogenesis. We previously reported that naïve B (NB) cells from patients with NMOSD, unlike those from healthy ...
High frequency of circulating non-classical monocytes is associated with stable remission in relapsing-remitting multiple sclerosis [0.03%]
循环非经典单核细胞的高频率与复发缓解型多发性硬化的稳定缓解相关
Misako Minote,Wakiro Sato,Kimitoshi Kimura et al.
Misako Minote et al.
'No evidence of disease activity (NEDA)', judged by clinical and radiological findings, is a therapeutic goal in patients with multiple sclerosis (MS). It is, however, unclear if distinct biological mechanisms contribute to the maintenance ...
Anti-aminoacyl tRNA synthetase antibodies showing the discrepancy between enzyme-linked immunosorbent assay and RNA-immunoprecipitation [0.03%]
抗氨酰tRNA合成酶抗体显示酶联免疫吸附试验和RNA免疫沉淀之间的差异
Tsuneo Sasai,Yuki Ishikawa,Ran Nakashima et al.
Tsuneo Sasai et al.
Anti-aminoacyl-tRNA synthetase (ARS) antibodies are myositis-specific antibodies associated with anti-synthetase syndrome (ASSD). Some patients are positive for anti-ARS antibodies on enzyme-linked immunosorbent assay (ELISA) but negative o...
Safety risks of interstitial lung disease upon real-world usage of Janus kinase inhibitors and biologics for patients with autoimmune diseases: epidemiological study using nationwide electronic medical record database in Japan [0.03%]
对自身免疫性疾病患者而言，Janus激酶抑制剂和生物制剂在实际使用中所导致的间质性肺病的安全风险：利用日本全国电子医疗记录数据库进行的流行病学研究
Mihoko Yabuuchi,Kazuhito Yokoyama
Mihoko Yabuuchi
Although Janus kinase inhibitor (JAKi) therapy is used for patients with autoimmune diseases (AD), one safety concern, interstitial lung disease (ILD), is life-threatening. We evaluated actual usage of JAKi and safety upon JAKi treatment, i...
Prophylactic immunoglobulin therapy for pediatric congenital myotonic dystrophy [0.03%]
儿童先天性肌强直性营养不良的预防性免疫球蛋白治疗
Yoji Uejima,Satoshi Sato
Yoji Uejima
Congenital Myotonic Dystrophy (CMD) is an autosomal dominant hereditary disease caused by mutations in the dystrophia myotonica protein kinase gene. Patients with CMD often exhibit low immunoglobulin (Ig) G levels. While Ig replacement ther...
NF9 peptide specific cytotoxic T lymphocyte clone cross react to Y453F mutation of SARS-CoV-2 virus spike protein [0.03%]
NF9肽特异性细胞毒性T淋巴细胞克隆与SARS-CoV-2病毒刺突蛋白的Y453F突变发生交叉反应
Aiko Murai,Terufumi Kubo,Takayuki Ohkuri et al.
Aiko Murai et al.
The recognition by cytotoxic T cells (CTLs) is essential for the clearance of SARS-CoV-2 virus-infected cells. Several viral proteins have been described to be recognized by CTLs. Among them, the spike (S) protein is one of the immunogenic ...
Efficacy and safety of mycophenolate mofetil for steroid reduction in neuromyelitis optica spectrum disorder: a prospective cohort study [0.03%]
米锋霉酚酸酯用于视神经脊髓炎谱系障碍糖皮质激素减量的疗效和安全性：队列研究
Ritsu Akatani,Norio Chihara,Shusuke Koto et al.
Ritsu Akatani et al.
Neuromyelitis optica spectrum disorder (NMOSD) is a rare autoimmune inflammatory disease that can affect multiple generations and cause complications with long-term prednisolone treatment. This study aimed to evaluate the efficacy and safet...
Risk of disease flares after SARS-CoV-2 mRNA vaccination in patients with systemic lupus erythematosus [0.03%]
SARS-CoV-2 mRNA疫苗接种后系统性红斑狼疮患者疾病复发的风险
Jun Kikuchi,Yasushi Kondo,Shuichiro Kojima et al.
Jun Kikuchi et al.
This study aims to elucidate the effectiveness and safety of SARS-CoV-2 mRNA vaccination in patients with systemic lupus erythematosus (SLE). We enrolled uninfected SLE patients who received two vaccine doses (BNT162b2 or mRNA-1273) and his...
Possible correlation between serum interleukin-8 levels and the activity of myositis in anti-NXP2 antibody-positive dermatomyositis [0.03%]
抗NXP2抗体阳性皮肤炎肌炎的血清白细胞介素-8水平与肌炎活动度之间的可能相关性
Risa Konishi,Yuki Ichimura,Ryota Tanaka et al.
Risa Konishi et al.
Anti-nuclear matrix protein 2 (NXP2) antibody-positive dermatomyositis (DM) is characterized by extensive and severe myositis. In this study, we evaluated which cytokines/chemokines involved with the activity of the myositis. We performed q...
Synovial-tissue resident macrophages play proinflammatory functions in the pathogenesis of RA while maintaining the phenotypes in the steady state [0.03%]
滑膜组织驻留的巨噬细胞在稳态下维持表型的同时在RA的发病机理中发挥促炎功能
Kazuhiro Kai,Hisakata Yamada,Ryosuke Tsurui et al.
Kazuhiro Kai et al.
Synovial tissue-resident macrophages (STRMs) maintain normal joint homeostasis in a steady state. However, it is unclear whether STRMs still play homeostatic roles or change the functions in the joint of rheumatoid arthritis (RA), where inf...