Tomoyuki Minowa,Kenji Murata,Stephanie S Watowich et al.
Tomoyuki Minowa et al.
Acral melanoma (AM) is a distinct subtype of melanoma that arises on sun protected skin of the palms, soles, and nail beds, and is the most common melanoma subtype in non-Caucasian populations. Despite recent advances in cancer immunotherap...
Comprehensive management of immune-related adverse events: predictive strategies, mechanistic insights, and therapeutic approaches [0.03%]
免疫相关不良事件的综合管理：预测策略、机制见解和治疗方案
Kosaku Murakami
Kosaku Murakami
Immune checkpoint inhibitors (ICIs) have been game changer in cancer therapy but can trigger diverse immune-related adverse events (irAEs) that impact multiple organs. This review offers a unified perspective on irAE risk assessment, underl...
Expression of MS4A4A on synovial infiltrating macrophages is a hallmark of rheumatoid arthritis and reflects disease severity [0.03%]
滑膜浸润巨噬细胞MS4A4A表达是类风湿关节炎的标志，反映了疾病的严重程度
Hirotomo Asakura,Yu Matsueda,Keisuke Ikeda et al.
Hirotomo Asakura et al.
Macrophages play a pivotal role in the progression of synovitis and joint destruction in rheumatoid arthritis (RA). MS4A4A, a transmembrane protein, has been linked to RA disease activity, but its role in synovitis remains unclear. The pres...
Eosinophilic cholangitis mimicking IgG4-related sclerosing cholangitis in an older female patient [0.03%]
一名老年女性患者中以IgG4相关硬化性胆管炎样形式表现的嗜酸性粒细胞胆管炎病例报告
Misa Kasahara,Keisuke Ojiro,Makoto Ueno et al.
Misa Kasahara et al.
Eosinophilic cholangitis (EC) is a rare, benign disorder characterized by eosinophilic infiltration of the bile ducts, often mimicking cholangiocarcinoma or sclerosing cholangitis. In this report, we present the case of an 84-year-old woman...
Use of oral Janus kinase inhibitors for the treatment of severe alopecia areata: narrative review and real-world experience [0.03%]
口服 janus 激酶抑制剂治疗重度斑秃：叙述性回顾与真实世界案例体验
Manabu Ohyama,Masahiro Fukuyama,Reina Hayakawa et al.
Manabu Ohyama et al.
Alopecia areata (AA) is a common autoimmune, non-scarring hair loss disease in which anagen hair follicles are predominantly affected. Typically, from a single to multiple and round to oval patchy hair loss is observed in AA with a tendency...
A case of refractory Mooren's ulcer successfully treated with systemic immunosuppressive therapy [0.03%]
难治性莫尔斯溃疡采用系统免疫抑制疗法的病例报告
Erika Yumori-Matsunaka,Kaoru Araki-Sasaki,Atsuko Ishimoto et al.
Erika Yumori-Matsunaka et al.
We will report the efficacy and precautions for the systemic administration of immunosuppressants in refractory Mooren's ulcer. A 65-year-old woman with refractory Mooren's ulcer was referred to our hospital. Initial visual acuity was 0.01 ...
Recovery trajectories of TAFRO syndrome: a single-center case series highlighting prolonged thrombocytopenia and anasarca [0.03%]
TAFRO综合征恢复轨迹：单中心病例系列强调长时间血小板减少和全身水肿
Chiharu Miyamoto,Yo Ueda,Hirotaka Yamada et al.
Chiharu Miyamoto et al.
TAFRO syndrome is a rare systemic inflammatory disorder characterized by thrombocytopenia, anasarca, fever or inflammation, reticulin fibrosis or renal dysfunction, and organomegaly. Despite increasing recognition, its natural history, part...
Association between Psoriasis Area and Severity Index Score and atherosclerotic risk in psoriasis patients using the Hisayama Score: a single-center retrospective study [0.03%]
日本久山评分在银屑病患者中的应用：关于银屑病面积严重性指数与动脉粥样硬化风险之间相关性的单中心回顾性研究
Airi Kobayashi,Hitoshi Terui,Ryoko Shimada-Omori et al.
Airi Kobayashi et al.
Psoriasis is a chronic immune-mediated skin disorder causing systemic inflammation, which significantly increases the risk of cardiovascular disease (CVD). In Japan, the Hisayama Score was recently introduced as a comprehensive tool to asse...
A patient with WHIM syndrome presenting relatively low TREC, KREC, and housekeeping gene levels by newborn screening -a case report and the literature review [0.03%]
WHIM综合征患儿新生儿筛查TRECKRECluc基因水平偏低1例及相关文献复习
Yuta Azuma,Shinsuke Hirabayashi,Masahiro Ueki et al.
Yuta Azuma et al.
WHIM syndrome is the inborn errors of immunity characterized by warts, hypogammaglobulinemia, infections, and myelokathexis, by the pathogenic variant in CXCR4. Patients with WHIM syndrome demonstrate neutropenia and lymphopenia due to the ...
Pharmacokinetics, safety and tolerability, and efficacy of hyaluronidase-facilitated subcutaneous immunoglobulin 10% (HyQvia®) in Japanese patients with primary immunodeficiency diseases [0.03%]
用于原发性免疫缺陷病日本患者的透明质酸酶辅助皮下注射免疫球蛋白10%（HyQvia®）的药代动力学、安全性、耐受性和疗效研究
Hirokazu Kanegane,Masataka Ishimura,Eisuke Suganuma et al.
Hirokazu Kanegane et al.
This phase 3 open-label study (jRCT2031210457; NCT05150340; January 2022-August 2023) evaluated pharmacokinetics, safety and tolerability, and efficacy of recombinant hyaluronidase-facilitated subcutaneous immunoglobulin (fSCIG) 10% in Japa...