The role of NK cells in oncolytic viral therapy: a focus on hepatocellular carcinoma [0.03%]
自然杀伤细胞在溶瘤病毒疗法中的作用：以肝癌为例
Frazer Warricker,Salim I Khakoo,Matthew D Blunt
Frazer Warricker
Natural killer (NK) cells have a key role in host anti-tumour immune responses via direct killing of tumour cells and promotion of adaptive immune responses. They are therefore attractive targets to promote the anti-tumour efficacy of oncol...
Roles of interacting stress-related genes in lifespan regulation: insights for translating experimental findings to humans [0.03%]
相互作用的压力相关基因在寿命调节中的角色：将实验结果转化为人类的见解
Anatoliy I Yashin,Deqing Wu,Konstantin Arbeev et al.
Anatoliy I Yashin et al.
Aim: Experimental studies provided numerous evidence that caloric/dietary restriction may improve health and increase the lifespan of laboratory animals, and that the interplay among molecules that sense cellular stress s...
Genome-wide homozygosity and risk of four non-Hodgkin lymphoma subtypes [0.03%]
全基因组纯合性和四种非霍奇金淋巴瘤亚型的风险的关系
Amy Moore,Mitchell J Machiela,Moara Machado et al.
Amy Moore et al.
Aim: Recessive genetic variation is thought to play a role in non-Hodgkin lymphoma (NHL) etiology. Runs of homozygosity (ROH), defined based on long, continuous segments of homozygous SNPs, can be used to estimate both me...
Shared genomic segment analysis in a large high-risk chronic lymphocytic leukemia pedigree implicates CXCR4 in inherited risk [0.03%]
大型高风险慢性淋巴细胞白血病谱系的共享基因组片段分析暗示CXCR4在遗传易感性中的作用
Julie E Feusier,Michael J Madsen,Brian J Avery et al.
Julie E Feusier et al.
Aim: Chronic lymphocytic leukemia (CLL) has been shown to cluster in families. First-degree relatives of individuals with CLL have an ~8 fold increased risk of developing the malignancy. Strong heritability suggests pedig...
Kava root extracts hinder prostate cancer development and tumorigenesis by involvement of dual inhibition of MAO-A and LSD1 [0.03%]
密克罗忍冬抗前列腺癌作用及机制研究
Xuesen Li,Liankun Song,Shan Xu et al.
Xuesen Li et al.
Aim: Here, we aim to evaluate the chemopreventive efficacy of kava root extracts (KRE) in transgenic adenocarcinoma of the mouse prostate (TRAMP) mice and investigate potential molecular targets of kavalactones, the main ...
Toward uncharted territory of cellular heterogeneity: advances and applications of single-cell RNA-seq [0.03%]
单细胞RNA测序的最新进展及应用展望——探索异质性的未知领域
Brandon Lieberman,Meena Kusi,Chia-Nung Hung et al.
Brandon Lieberman et al.
Among single-cell analysis technologies, single-cell RNA-seq (scRNA-seq) has been one of the front runners in technical inventions. Since its induction, scRNA-seq has been well received and undergone many fast-paced technical improvements i...
Discovery of rare variants implicated in schizophrenia using next-generation sequencing [0.03%]
运用下一代测序技术发现与精神分裂症有关的罕见变异体
Raina Rhoades,Fatimah Jackson,Shaolei Teng
Raina Rhoades
Schizophrenia is a highly heritable psychiatric disorder that affects 1% of the population. Genome-wide association studies have identified common variants in candidate genes associated with schizophrenia, but the genetics mechanisms of thi...
Prostate cancer in young men represents a distinct clinical phenotype: gene expression signature to predict early metastases [0.03%]
年轻男性的前列腺癌是一种特有的临床类型：基因表达特征预测早期转移
Yuan C Ding,Huiqing Wu,Elai Davicioni et al.
Yuan C Ding et al.
Aim: Several genomic signatures are available to predict Prostate Cancer (CaP) outcomes based on gene expression in prostate tissue. However, no signature was tailored to predict aggressive CaP in younger men. We attempte...
Mitochondrial diseases: expanding the diagnosis in the era of genetic testing [0.03%]
线粒体病的遗传学诊断时代来临
Russell P Saneto
Russell P Saneto
Mitochondrial diseases are clinically and genetically heterogeneous. These diseases were initially described a little over three decades ago. Limited diagnostic tools created disease descriptions based on clinical, biochemical analytes, neu...
Bryn D Webb,George A Diaz,Pankaj Prasun
Bryn D Webb
In eukaryotic cells, mitochondria perform the essential function of producing cellular energy in the form of ATP via the oxidative phosphorylation system. This system is composed of 5 multimeric protein complexes of which 13 protein subunit...