Optical Estimation of Membrane Potential Values Using Fluorescence Lifetime Imaging Microscopy and Hybrid Chemical-Genetic Voltage Indicators [0.03%]
基于荧光寿命成像显微镜和杂合化学-遗传电压指示剂的膜电位光学估算方法
Anneliese M M Gest,Vincent Grenier,Evan W Miller
Anneliese M M Gest
Introduction: Membrane potential (Vm), the voltage across a cell membrane, is an important biophysical phenomenon, central to the physiology of cells, tissues, and organisms. Voltage-sensitive fluorescent indicators are a...
Laura Faith George,Mikaela Lynn Follmer,Emily Fontenoy et al.
Laura Faith George et al.
Background: The temporal dynamics of morphogen presentation impacts transcriptional responses and tissue patterning. However, the mechanisms controlling morphogen release are far from clear. We found that inwardly rectify...
Lilian I Plotkin,Iqra Asad,Alex E Kritikos et al.
Lilian I Plotkin et al.
The presence of gap junction intercellular communication structures in bone cells has been known since the early 1970s, further confirmed by Doty and Marotti at the structural level in the 1980-1990s. Work by Civitelli, Donahue, and others ...
The Role of Gap Junctions Dysfunction in the Development of Cataracts: From Loss of Cell-to-Cell Transfer to Blurred Vision-Review [0.03%]
连接蛋白功能障碍在白内障发生发展中的作用：从细胞间通讯丧失到视物模糊
Jose F Ek-Vitorin,Jean X Jiang
Jose F Ek-Vitorin
Mutations of lens connexins are linked to congenital cataracts. However, the role of connexin mutations in the development of age-related lens opacification remains largely unknown. Here, we present a focused review of the literature on len...
Retinoic Acid Influences connexin43 Expression During Joint Formation in the Regenerating Zebrafish Fin [0.03%]
视黄酸影响再生斑马鱼鳍关节形成过程中连接蛋白43的表达
Alexander W Seaver,Noah S Weaver,M Kathryn Iovine
Alexander W Seaver
Background: The regenerating zebrafish fin skeleton is comprised of multiple bony fin rays, each made of alternating bony segments and fin ray joints. This pattern is regulated by the gap junction protein Connexin43 (Cx43...
Channel Behavior and Voltage Gating of a Cx43 Mutant Simulating Preconditioning [0.03%]
模仿预处理的Cx43突变体通道的行为及其电压门控功能
Jose F Ek-Vitorin,Diego Silva-Mendoza,Tasha K Pontifex et al.
Jose F Ek-Vitorin et al.
Background: Ischemic preconditioning induces lateralization and dephosphorylation of Connexin 43 (Cx43). However, the Cx43 protein that remains at intercalated disks may be phosphorylated by casein kinase 1 (CK1) and prot...
Luis A Pardo
Luis A Pardo
Bioelectricity goes far beyond electrical signaling in the nervous system, but this was initially not obvious for me. This article describes the journey from studying the biophysics of ion channels in classical electrically excitable tissue...
Modeling Electrostatic Charge Shielding Induced by Cationic Drug Carriers in Articular Cartilage Using Donnan Osmotic Theory [0.03%]
利用唐南渗透理论对阳离子药物载体在关节软骨中引起的静电荷屏蔽进行建模
Matthew R Warren,Ambika G Bajpayee
Matthew R Warren
Background: Positively charged drug carriers are rapidly emerging as a viable solution for long-standing challenges in delivery to dense, avascular, negatively charged tissues. These cationic carriers have demonstrated es...
Alistair V W Nunn,Geoffrey W Guy,Jimmy D Bell
Alistair V W Nunn
The consensus on the origins of life is that it involved organization of prebiotic chemicals according to the underlying principles of thermodynamics to dissipate energy derived from photochemical and/or geochemical sources. Leading theorie...
Determination of the Effects of Transcutaneous Auricular Vagus Nerve Stimulation on the Heart Rate Variability Using a Machine Learning Pipeline [0.03%]
基于机器学习流程的经皮耳迷走神经刺激对心率变异性影响的研究
Anna Tarasenko,Stefano Guazzotti,Thomas Minot et al.
Anna Tarasenko et al.
Background: We are all aware of day-to-day healthy stress, but, when sustained for long periods, stress is believed to lead to serious physical and mental health issues. ...