Preventing Ethanol-Induced Brain and Eye Morphology Defects Using Optogenetics [0.03%]
利用光遗传学预防乙醇诱导的脑和眼形态缺陷
Vaibhav P Pai,Dany Spencer Adams
Vaibhav P Pai
Background: Embryonic exposure to the teratogen ethanol leads to dysmorphias, including eye and brain morphology defects associated with fetal alcohol spectrum disorder (FASD). Exposure of Xenopus laevis embryos to ethanol leads to similar ...
Johanna U Neuber,Frency Varghese,Andrei G Pakhomov et al.
Johanna U Neuber et al.
The purpose of this review article is to summarize our current understanding of the efficacy and safety of cardiac defibrillation with nanosecond shocks. Experiments in isolated hearts, using optical mapping of the electrical activity, have...
Interferon-Gamma Stimulated Murine Macrophages In Vitro: Impact of Ionic Composition and Osmolarity and Therapeutic Implications [0.03%]
离子强度和渗透压对干扰素γ刺激的单核-巨噬细胞的影响及治疗意义
Joshua Erndt-Marino,Daniel J Yeisley,Hongyu Chen et al.
Joshua Erndt-Marino et al.
Background: Injections of osmolytes are promising immunomodulatory treatments for medical benefit, although the rationale and underlying mechanisms are often lacking. The goals of the present study were twofold: (1) to clarify the anti-infl...
Assessment of Enrichment of Human Mesenchymal Stem Cells Based on Plasma and Mitochondrial Membrane Potentials [0.03%]
基于血浆和线粒体膜电位的人间质干细胞富集评估
Timothy Kamaldinov,Josh Erndt-Marino,Michael Levin et al.
Timothy Kamaldinov et al.
Background: Human mesenchymal stem cells (hMSCs) are utilized preclinically and clinically as a candidate cell therapy for a wide range of inflammatory and degenerative diseases. Despite promising results in early clinical trials, consisten...
Samantha L Payne,Michael Levin,Madeleine J Oudin
Samantha L Payne
As the leading cause of death in cancer, there is an urgent need to develop treatments to target the dissemination of primary tumor cells to secondary organs, known as metastasis. Bioelectric signaling has emerged in the last century as an ...
D-Amphetamine Exposure Differentially Disrupts Signaling Across Ontogeny in the Zebrafish [0.03%]
D-安非他明暴露在斑马鱼发育过程中不同阶段信号转导的差异性干扰作用
Bradley J Serpa,Jennifer D Bullard,Victoria C Mendiola et al.
Bradley J Serpa et al.
Background: Prescriptive and illicit amphetamine (AMPH) use continues to increase along with the likelihood that during an individual's lifetime, the drug deleteriously influences the growth and connectivity of behavior circuits necessary f...
Membrane Potential Depolarization Alters Calcium Flux and Phosphate Signaling During Osteogenic Differentiation of Human Mesenchymal Stem Cells [0.03%]
去极化改变人源间充质干细胞成骨分化过程中的钙离子流动和磷信号转导路径
Sarah Sundelacruz,Amy Thurber Moody,Michael Levin et al.
Sarah Sundelacruz et al.
Background: Membrane potential (Vmem) changes accompany important events in embryonic development and organ regeneration. Recent studies have pointed to its function as a potent regulator of cell proliferation, differentiation, migration, a...
Separation of Macrophages and Fibroblasts Using Contactless Dielectrophoresis and a Novel ImageJ Macro [0.03%]
基于非接触介电泳和新型ImageJ宏程序的巨噬细胞与成纤维细胞分选法
Temple Anne Douglas,Nastaran Alinezhadbalalami,Nikita Balani et al.
Temple Anne Douglas et al.
Background: This study presents a label-free method of separating macrophages and fibroblasts, cell types critically associated with tumors. Materials and Methods: Contactless dielectrophoresis (DEP) devices were used to separate fibroblast...