Guiding a Revolution [0.03%]
引领一场革命
Dany Spencer Adams
Dany Spencer Adams
Enhancing Cell Viability and Efficiency of Plasmid DNA Electrotransfer Through Reducing Plasma Membrane Permeabilization [0.03%]
通过减少细胞膜通透性增强质粒DNA电转染的细胞活力和效率
Yanhua Wang,Chun-Chi Chang,Liangli Wang et al.
Yanhua Wang et al.
Background: Pulsed electric field has been widely used to facilitate molecular cargo transfer into cells. However, the cell viability is often decreased when trying to increase the electrotransfer efficiency. We hypothesi...
Functional Applications of Polyarginine-Hyaluronic Acid-Based Electrostatic Complexes [0.03%]
聚精氨酸-透明质酸基静电复合物的功能应用
Narendra R Kale,Debasmita Dutta,William Carstens et al.
Narendra R Kale et al.
Background: Electrostatic complexes of poly (l-Arginine) (pArg) and hyaluronic acid (HA) have been investigated for their functional applications to supply free or polymeric form of l-Arginine (Arg) to target cells. As a vital amino acid, A...
Duplex of Polyamidoamine Dendrimer/Custom-Designed Nuclear-Localization Sequence Peptide for Enhanced Gene Delivery [0.03%]
聚酰胺胺树状大分子/定制的核定位序列肽双层结构用于增强基因传递
Remy C Cooper,Hu Yang
Remy C Cooper
Background: Dendrimers are an attractive alternative to viral vectors due to the low cost of production, larger genetic insert-carrying capacity, and added control over immune- and genotoxic complications through versatile functionalization...
Shreedevi Kumar,Blanka Sharma
Shreedevi Kumar
Arthritis is a debilitating joint disease with a high economic burden and prevalence. There are many challenges delivering therapeutics to the joint, including low bioavailability when administered systemically and low joint retention after...
Bioelectricity for Drug Delivery: The Promise of Cationic Therapeutics [0.03%]
药物传输中的生物电现象：阳离子类药剂的前景
Cameron C Young,Armin Vedadghavami,Ambika G Bajpayee
Cameron C Young
Biological systems overwhelmingly comprise charged entities generating electrical activity that can have significant impact on biological structure and function. This intrinsic bio-electrical activity can also be harnessed for overcoming th...
Preventing Ethanol-Induced Brain and Eye Morphology Defects Using Optogenetics [0.03%]
利用光遗传学预防乙醇诱导的脑和眼形态缺陷
Vaibhav P Pai,Dany Spencer Adams
Vaibhav P Pai
Background: Embryonic exposure to the teratogen ethanol leads to dysmorphias, including eye and brain morphology defects associated with fetal alcohol spectrum disorder (FASD). Exposure of Xenopus laevis embryos to ethanol leads to similar ...
Johanna U Neuber,Frency Varghese,Andrei G Pakhomov et al.
Johanna U Neuber et al.
The purpose of this review article is to summarize our current understanding of the efficacy and safety of cardiac defibrillation with nanosecond shocks. Experiments in isolated hearts, using optical mapping of the electrical activity, have...
Interferon-Gamma Stimulated Murine Macrophages In Vitro: Impact of Ionic Composition and Osmolarity and Therapeutic Implications [0.03%]
离子强度和渗透压对干扰素γ刺激的单核-巨噬细胞的影响及治疗意义
Joshua Erndt-Marino,Daniel J Yeisley,Hongyu Chen et al.
Joshua Erndt-Marino et al.
Background: Injections of osmolytes are promising immunomodulatory treatments for medical benefit, although the rationale and underlying mechanisms are often lacking. The goals of the present study were twofold: (1) to clarify the anti-infl...
Assessment of Enrichment of Human Mesenchymal Stem Cells Based on Plasma and Mitochondrial Membrane Potentials [0.03%]
基于血浆和线粒体膜电位的人间质干细胞富集评估
Timothy Kamaldinov,Josh Erndt-Marino,Michael Levin et al.
Timothy Kamaldinov et al.
Background: Human mesenchymal stem cells (hMSCs) are utilized preclinically and clinically as a candidate cell therapy for a wide range of inflammatory and degenerative diseases. Despite promising results in early clinical trials, consisten...