Heidi Beate Bentzen
Heidi Beate Bentzen
There is a need to share personal data across jurisdictional boundaries. However, the laws regulating such transfers are not harmonized, and sometimes even conflict, causing challenges and occasional data stalls. This review describes the l...
Integration of Protein Structure and Population-Scale DNA Sequence Data for Disease Gene Discovery and Variant Interpretation [0.03%]
蛋白质结构与人口尺度DNA序列数据的整合在疾病基因发现和变异解析中的应用
Bian Li,Bowen Jin,John A Capra et al.
Bian Li et al.
The experimental and computational techniques for capturing information about protein structures and genetic variation within the human genome have advanced dramatically in the past 20 years, generating extensive new data resources. In this...
Genome Privacy and Trust [0.03%]
基因组隐私和信任感
Gamze Gürsoy
Gamze Gürsoy
Genomics data are important for advancing biomedical research, improving clinical care, and informing other disciplines such as forensics and genealogy. However, privacy concerns arise when genomic data are shared. In particular, the identi...
Elise D Flynn,Tuuli Lappalainen
Elise D Flynn
Thousands of common genetic variants in the human population have been associated with disease risk and phenotypic variation by genome-wide association studies (GWAS). However, the majority of GWAS variants fall into noncoding regions of th...
Ruth Nussinov,Hyunbum Jang,Guy Nir et al.
Ruth Nussinov et al.
Three-dimensional protein structural data at the molecular level are pivotal for successful precision medicine. Such data are crucial not only for discovering drugs that act to block the active site of the target mutant protein but also for...
Cotranslational Mechanisms of Protein Biogenesis and Complex Assembly in Eukaryotes [0.03%]
真核生物中蛋白质生物发生和复合物组装的协同翻译机制
Fabián Morales-Polanco,Jae Ho Lee,Natália M Barbosa et al.
Fabián Morales-Polanco et al.
The formation of protein complexes is crucial to most biological functions. The cellular mechanisms governing protein complex biogenesis are not yet well understood, but some principles of cotranslational and posttranslational assembly are ...
Static and Motion Facial Analysis for Craniofacial Assessment and Diagnosing Diseases [0.03%]
基于静态和动态人脸分析的颅面评估及疾病诊断方法研究
Harold Matthews,Guido de Jong,Thomas Maal et al.
Harold Matthews et al.
Deviation from a normal facial shape and symmetry can arise from numerous sources, including physical injury and congenital birth defects. Such abnormalities can have important aesthetic and functional consequences. Furthermore, in clinical...
Raquel Rodríguez-Pérez,Filip Miljković,Jürgen Bajorath
Raquel Rodríguez-Pérez
In chemoinformatics and medicinal chemistry, machine learning has evolved into an important approach. In recent years, increasing computational resources and new deep learning algorithms have put machine learning onto a new level, addressin...
Phenotypic Causal Inference Using Genome-Wide Association Study Data: Mendelian Randomization and Beyond [0.03%]
利用基因组关联数据进行表型因果推理：从孟德尔随机化到更广泛的应用
Venexia M Walker,Jie Zheng,Tom R Gaunt et al.
Venexia M Walker et al.
statistics for genome-wide association studies (GWAS) are increasingly available for downstream analyses. Meanwhile, the popularity of causal inference methods has grown as we look to gather robust evidence for novel medical and public heal...
Amit Singer,Fred J Sigworth
Amit Singer
Single-particle electron cryomicroscopy (cryo-EM) is an increasingly popular technique for elucidating the three-dimensional structure of proteins and other biologically significant complexes at near-atomic resolution. It is an imaging meth...