Computational Approaches to Drug Repurposing: Methods, Challenges, and Opportunities [0.03%]
药物再定位的计算方法：方法、挑战及机遇
Henry C Cousins,Gowri Nayar,Russ B Altman
Henry C Cousins
Drug repurposing refers to the inference of therapeutic relationships between a clinical indication and existing compounds. As an emerging paradigm in drug development, drug repurposing enables more efficient treatment of rare diseases, str...
Identification of Splice Variants and Isoforms in Transcriptomics and Proteomics [0.03%]
转录组学和蛋白质组学中拼接变异体和异构体的鉴定
Taojunfeng Su,Michael A R Hollas,Ryan T Fellers et al.
Taojunfeng Su et al.
Alternative splicing is pivotal to the regulation of gene expression and protein diversity in eukaryotic cells. The detection of alternative splicing events requires specific omics technologies. Although short-read RNA sequencing has succes...
The All of Us Data and Research Center: Creating a Secure, Scalable, and Sustainable Ecosystem for Biomedical Research [0.03%]
全民医学研究数据中心：打造安全、可拓展和可持续的生物医学研究生态系统
Kelsey R Mayo,Melissa A Basford,Robert J Carroll et al.
Kelsey R Mayo et al.
The All of Us Research Program's Data and Research Center (DRC) was established to help acquire, curate, and provide access to one of the world's largest and most diverse datasets for precision medicine research. Already, over 500,000 parti...
Morten Nielsen,Massimo Andreatta,Bjoern Peters et al.
Morten Nielsen et al.
Immunoinformatics is a discipline that applies methods of computer science to study and model the immune system. A fundamental question addressed by immunoinformatics is how to understand the rules of antigen presentation by MHC molecules t...
Toward Identification of Functional Sequences and Variants in Noncoding DNA [0.03%]
面向非编码DNA中功能序列及变异的鉴定
Remo Monti,Uwe Ohler
Remo Monti
Understanding the noncoding part of the genome, which encodes gene regulation, is necessary to identify genetic mechanisms of disease and translate findings from genome-wide association studies into actionable results for treatments and per...
Recent Developments in Ultralarge and Structure-Based Virtual Screening Approaches [0.03%]
基于结构的和超大型虚拟筛选的近况与发展
Christoph Gorgulla
Christoph Gorgulla
Drug development is a wide scientific field that faces many challenges these days. Among them are extremely high development costs, long development times, and a small number of new drugs that are approved each year. New and innovative tech...
Noninvasive Prenatal Testing Using Circulating DNA and RNA: Advances, Challenges, and Possibilities [0.03%]
循环DNA和RNA的非侵入性产前检测：进展、挑战及可能带来的影响
Mira N Moufarrej,Diana W Bianchi,Gary M Shaw et al.
Mira N Moufarrej et al.
Prenatal screening using sequencing of circulating cell-free DNA has transformed obstetric care over the past decade and significantly reduced the number of invasive diagnostic procedures like amniocentesis for genetic disorders. Nonetheles...
Pankhuri Singhal,Shefali Setia Verma,Marylyn D Ritchie
Pankhuri Singhal
Despite monumental advances in molecular technology to generate genome sequence data at scale, there is still a considerable proportion of heritability in most complex diseases that remains unexplained. Because many of the discoveries have ...
Human Genomics of COVID-19 Pneumonia: Contributions of Rare and Common Variants [0.03%]
罕见和常见变异对COVID-19肺炎的人类基因组学的贡献
Aurélie Cobat,Qian Zhang;COVID Human Genetic Effort;Laurent Abel,Jean-Laurent Casanova et al.
Aurélie Cobat et al.
SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection is silent or benign in most infected individuals, but causes hypoxemic COVID-19 pneumonia in about 10% of cases. We review studies of the human genetics of life-threaten...
Importance of Diversity in Precision Medicine: Generalizability of Genetic Associations Across Ancestry Groups Toward Better Identification of Disease Susceptibility Variants [0.03%]
精准医学中多样性的重要性：跨祖先群体遗传关联的普适性以更好地识别疾病易感变异
Lauren A Cruz,Jessica N Cooke Bailey,Dana C Crawford
Lauren A Cruz
Genome-wide association studies (GWAS) revolutionized our understanding of common genetic variation and its impact on common human disease and traits. Developed and adopted in the mid-2000s, GWAS led to searchable genotype-phenotype catalog...