Conditional Generative Models for Synthetic Tabular Data: Applications for Precision Medicine and Diverse Representations [0.03%]
用于合成表格数据的条件生成模型：精准医学和多样表示的应用
Kara Liu,Russ B Altman
Kara Liu
Tabular medical datasets, like electronic health records (EHRs), biobanks, and structured clinical trial data, are rich sources of information with the potential to advance precision medicine and optimize patient care. However, real-world m...
Spatial Transcriptomics Brings New Challenges and Opportunities for Trajectory Inference [0.03%]
空间转录组学为轨迹推理带来新的挑战和机遇
Matthieu Heitz,Yujia Ma,Sharvaj Kubal et al.
Matthieu Heitz et al.
Spatial transcriptomics (ST) brings new dimensions to the analysis of single-cell data. While some methods for data analysis can be ported over without major modifications, they are the exception rather than the rule. Trajectory inference (...
Hyunghoon Cho,David Froelicher,Natnatee Dokmai et al.
Hyunghoon Cho et al.
The rapidly growing scale and variety of biomedical data repositories raise important privacy concerns. Conventional frameworks for collecting and sharing human subject data offer limited privacy protection, often necessitating the creation...
Disease Trajectories from Healthcare Data: Methodologies, Key Results, and Future Perspectives [0.03%]
医疗保健数据中的疾病轨迹：方法论、主要结果和未来展望
Isabella Friis Jørgensen,Amalie Dahl Haue,Davide Placido et al.
Isabella Friis Jørgensen et al.
Disease trajectories, defined as sequential, directional disease associations, have become an intense research field driven by the availability of electronic population-wide healthcare data and sufficient computational power. Here, we provi...
Michèle Ramsay,Amelia C Crampin,Ayaga A Bawah et al.
Michèle Ramsay et al.
Building longitudinal population cohorts in Africa for coordinated research and surveillance can influence the setting of national health priorities, lead to the introduction of appropriate interventions, and provide evidence for targeted t...
Employing Informatics Strategies in Alzheimer's Disease Research: A Review from Genetics, Multiomics, and Biomarkers to Clinical Outcomes [0.03%]
阿尔茨海默病研究中的信息学策略运用：从遗传、多组学及生物标志物到临床结局的综述
Jingxuan Bao,Brian N Lee,Junhao Wen et al.
Jingxuan Bao et al.
Alzheimer's disease (AD) is a critical national concern, affecting 5.8 million people and costing more than 250 billion annually. However, there is no available cure. Thus, effective strategies are in urgent need to discover AD biomarkers f...
Harnessing Artificial Intelligence in Multimodal Omics Data Integration: Paving the Path for the Next Frontier in Precision Medicine [0.03%]
利用人工智能整合多模态组学数据：推动精准医学的下一个前沿领域
Yonghyun Nam,Jaesik Kim,Sang-Hyuk Jung et al.
Yonghyun Nam et al.
The integration of multiomics data with detailed phenotypic insights from electronic health records marks a paradigm shift in biomedical research, offering unparalleled holistic views into health and disease pathways. This review delineates...
Spatially Resolved Single-Cell Omics: Methods, Challenges, and Future Perspectives [0.03%]
空间分辨单细胞组学：方法、挑战与未来前景
Felipe Segato Dezem,Natalia Silva Morosini,Wani Arjumand et al.
Felipe Segato Dezem et al.
Overlaying omics data onto spatial biological dimensions has been a promising technology to provide high-resolution insights into the interactome and cellular heterogeneity relative to the organization of the molecular microenvironment of t...
Ruth Johnson,Michelle M Li,Ayush Noori et al.
Ruth Johnson et al.
In clinical artificial intelligence (AI), graph representation learning, mainly through graph neural networks and graph transformer architectures, stands out for its capability to capture intricate relationships and structures within clinic...
Computational Methods for Predicting Key Interactions in T Cell-Mediated Adaptive Immunity [0.03%]
计算预测T细胞介导的适应性免疫的关键相互作用的方法
Ryan Ehrlich,Eric Glynn,Mona Singh et al.
Ryan Ehrlich et al.
The adaptive immune system recognizes pathogen- and cancer-specific features and is endowed with memory, enabling it to respond quickly and efficiently to repeated encounters with the same antigens. T cells play a central role in the adapti...