Toward Identification of Functional Sequences and Variants in Noncoding DNA [0.03%]
面向非编码DNA中功能序列及变异的鉴定
Remo Monti,Uwe Ohler
Remo Monti
Understanding the noncoding part of the genome, which encodes gene regulation, is necessary to identify genetic mechanisms of disease and translate findings from genome-wide association studies into actionable results for treatments and per...
Recent Developments in Ultralarge and Structure-Based Virtual Screening Approaches [0.03%]
基于结构的和超大型虚拟筛选的近况与发展
Christoph Gorgulla
Christoph Gorgulla
Drug development is a wide scientific field that faces many challenges these days. Among them are extremely high development costs, long development times, and a small number of new drugs that are approved each year. New and innovative tech...
Noninvasive Prenatal Testing Using Circulating DNA and RNA: Advances, Challenges, and Possibilities [0.03%]
循环DNA和RNA的非侵入性产前检测：进展、挑战及可能带来的影响
Mira N Moufarrej,Diana W Bianchi,Gary M Shaw et al.
Mira N Moufarrej et al.
Prenatal screening using sequencing of circulating cell-free DNA has transformed obstetric care over the past decade and significantly reduced the number of invasive diagnostic procedures like amniocentesis for genetic disorders. Nonetheles...
Pankhuri Singhal,Shefali Setia Verma,Marylyn D Ritchie
Pankhuri Singhal
Despite monumental advances in molecular technology to generate genome sequence data at scale, there is still a considerable proportion of heritability in most complex diseases that remains unexplained. Because many of the discoveries have ...
Human Genomics of COVID-19 Pneumonia: Contributions of Rare and Common Variants [0.03%]
罕见和常见变异对COVID-19肺炎的人类基因组学的贡献
Aurélie Cobat,Qian Zhang;COVID Human Genetic Effort;Laurent Abel,Jean-Laurent Casanova et al.
Aurélie Cobat et al.
SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection is silent or benign in most infected individuals, but causes hypoxemic COVID-19 pneumonia in about 10% of cases. We review studies of the human genetics of life-threaten...
Importance of Diversity in Precision Medicine: Generalizability of Genetic Associations Across Ancestry Groups Toward Better Identification of Disease Susceptibility Variants [0.03%]
精准医学中多样性的重要性：跨祖先群体遗传关联的普适性以更好地识别疾病易感变异
Lauren A Cruz,Jessica N Cooke Bailey,Dana C Crawford
Lauren A Cruz
Genome-wide association studies (GWAS) revolutionized our understanding of common genetic variation and its impact on common human disease and traits. Developed and adopted in the mid-2000s, GWAS led to searchable genotype-phenotype catalog...
Challenges and Progress in Designing Broad-Spectrum Vaccines Against Rapidly Mutating Viruses [0.03%]
针对快速变异病毒的广谱疫苗设计面临的挑战与进展
Rishi Bedi,Nicholas L Bayless,Jacob Glanville
Rishi Bedi
Viruses evolve to evade prior immunity, causing significant disease burden. Vaccine effectiveness deteriorates as pathogens mutate, requiring redesign. This is a problem that has grown worse due to population increase, global travel, and fa...
Single-Cell Multiomics [0.03%]
单细胞多组学
Emily Flynn,Ana Almonte-Loya,Gabriela K Fragiadakis
Emily Flynn
Single-cell RNA sequencing methods have led to improved understanding of the heterogeneity and transcriptomic states present in complex biological systems. Recently, the development of novel single-cell technologies for assaying additional ...
Combining Molecular and Radiomic Features for Risk Assessment in Breast Cancer [0.03%]
结合分子和影像组学特征进行乳腺癌风险评估
Alex A Nguyen,Anne Marie McCarthy,Despina Kontos
Alex A Nguyen
Breast cancer risk is highly variable within the population and current research is leading the shift toward personalized medicine. By accurately assessing an individual woman's risk, we can reduce the risk of over/undertreatment by prevent...
Vasileios Gouzouasis,Spyros Tastsoglou,Antonis Giannakakis et al.
Vasileios Gouzouasis et al.
MicroRNAs (miRNAs) are short noncoding RNAs that can regulate all steps of gene expression (induction, transcription, and translation). Several virus families, primarily double-stranded DNA viruses, encode small RNAs (sRNAs), including miRN...