Statistical Methods for Understanding Trajectories in Genetic Epidemiology [0.03%]
遗传流行病学中理解谱系轨迹的统计方法
Geng Wang,Lavinia Paternoster,Nicole M Warrington
Geng Wang
Genetic influences on how human traits change over time remain underexplored and may play an important role in disease processes. In this review, we explore emerging statistical approaches for incorporating longitudinal data on trait trajec...
Privacy and Security Throughout the Health Data Life Cycle: From Primary Care to Research Networks [0.03%]
全程保障医疗卫生数据隐私和安全：从初级保健到研究网络
Bradley A Malin,Chao Yan,Luca Bonomi
Bradley A Malin
Health data are increasingly generated, shared, and analyzed across an ever-growing collection of settings. While these developments enable new forms of biomedical discovery and clinical decision support, they also introduce evolving privac...
Electronic Health Record-Linked Biobank Expansion Reveals Global Health Inequities [0.03%]
基于电子健康记录的生物样本库扩展揭示了全球卫生不平等现象
Manuel Corpas,Oyesola Ojewunmi,Heinner Guio et al.
Manuel Corpas et al.
Electronic health record (EHR)-linked biobanks are transforming biomedical research, enabling population-scale studies that integrate genomic, clinical, and phenotypic data. Yet as these resources proliferate, it remains unclear how their r...
Precision Oncology: Multimodal and Multiscale Methods to Promote Mechanistic Understanding [0.03%]
精准肿瘤学：促进机制理解的多模态和多尺度方法
Kivilcim Ozturk,Adam Klie,Hannah Carter
Kivilcim Ozturk
Precision medicine aims to tailor treatment to the individual, improving medical outcomes and quality of life. Realizing this vision requires understanding how disease mechanisms and drug responses vary across patients. Advances in molecula...
Meta-Analysis and Federated Learning over Decentralized Distributed Research Networks [0.03%]
去中心化分布式研究网络上的元分析与联邦学习
Yiwen Lu,Bingyu Zhang,Jiayi Tong et al.
Yiwen Lu et al.
Distributed research networks have transformed modern clinical research by enabling large-scale, multi-institutional collaborations while maintaining patient privacy. Two prominent methodologies within these frameworks-meta-analysis and fed...
Yuehua Zhu,Weiguang Mao,Rezwan Hosseini et al.
Yuehua Zhu et al.
DNA methylation, a covalent modification, fundamentally shapes mammalian gene regulation and cellular identity. This review examines methylation's biochemical underpinnings, genomic distribution patterns, and analytical approaches. We highl...
Artificial Intelligence in Pathology: Advancing Large Models for Scalable Applications [0.03%]
病理学中的人工智能：推进大规模模型的应用规模
Zhiping Xiao,Bin Feng,Junwei Yang et al.
Zhiping Xiao et al.
The rapid development of artificial intelligence (AI) has had a significant impact on medical research, introducing new possibilities for pathology studies. There is a recent trend of applying large-scale AI models to many fields, and this ...
The Expanding Landscape of Neural Architectures and Their Impact in Biomedicine [0.03%]
神经架构的扩展及其在生物医学中的影响
Zijun Frank Zhang,Huixin Zhan,Tinghui Wu et al.
Zijun Frank Zhang et al.
Deep learning and artificial intelligence (AI) have seen explosive growth and success in biomedical applications in the last decade, largely due to the rapid development of deep neural networks and their underlying neural network (NN) archi...
Leveraging Unstructured Data in Electronic Health Records to Detect Adverse Events from Pediatric Drug Use: A Scoping Review [0.03%]
基于电子健康记录中的非结构化数据检测儿童用药不良事件的综述研究
Su Golder,Karen O&#x;Connor,Guillermo Lopez-Garcia et al.
Su Golder et al.
Adverse drug events (ADEs) in pediatric populations pose significant public health challenges, yet research on their detection and monitoring remains limited. This scoping review evaluates the use of unstructured data from electronic health...
Justin Kauffman,Riccardo Miotto,Eyal Klang et al.
Justin Kauffman et al.
This review aims to elucidate the role and impact of embedding techniques in the analysis and utilization of electronic health record data for research. By integrating multidimensional, incongruent, and often unstructured medical data for m...