Static and Motion Facial Analysis for Craniofacial Assessment and Diagnosing Diseases [0.03%]
基于静态和动态人脸分析的颅面评估及疾病诊断方法研究
Harold Matthews,Guido de Jong,Thomas Maal et al.
Harold Matthews et al.
Deviation from a normal facial shape and symmetry can arise from numerous sources, including physical injury and congenital birth defects. Such abnormalities can have important aesthetic and functional consequences. Furthermore, in clinical...
Raquel Rodríguez-Pérez,Filip Miljković,Jürgen Bajorath
Raquel Rodríguez-Pérez
In chemoinformatics and medicinal chemistry, machine learning has evolved into an important approach. In recent years, increasing computational resources and new deep learning algorithms have put machine learning onto a new level, addressin...
Phenotypic Causal Inference Using Genome-Wide Association Study Data: Mendelian Randomization and Beyond [0.03%]
利用基因组关联数据进行表型因果推理：从孟德尔随机化到更广泛的应用
Venexia M Walker,Jie Zheng,Tom R Gaunt et al.
Venexia M Walker et al.
statistics for genome-wide association studies (GWAS) are increasingly available for downstream analyses. Meanwhile, the popularity of causal inference methods has grown as we look to gather robust evidence for novel medical and public heal...
Amit Singer,Fred J Sigworth
Amit Singer
Single-particle electron cryomicroscopy (cryo-EM) is an increasingly popular technique for elucidating the three-dimensional structure of proteins and other biologically significant complexes at near-atomic resolution. It is an imaging meth...
Tracey Holloway,Daegan Miller,Susan Anenberg et al.
Tracey Holloway et al.
Data from satellite instruments provide estimates of gas and particle levels relevant to human health, even pollutants invisible to the human eye. However, the successful interpretation of satellite data requires an understanding of how sat...
Nicola Mulder,Lyndon Zass,Yosr Hamdi et al.
Nicola Mulder et al.
African populations are diverse in their ethnicity, language, culture, and genetics. Although plagued by high disease burdens, until recently the continent has largely been excluded from biomedical studies. Along with limitations in researc...
Neoantigen Controversies [0.03%]
neoantigen争议
Andrea Castro,Maurizio Zanetti,Hannah Carter
Andrea Castro
Next-generation sequencing technologies have revolutionized our ability to catalog the landscape of somatic mutations in tumor genomes. These mutations can sometimes create so-called neoantigens, which allow the immune system to detect and ...
Using Phecodes for Research with the Electronic Health Record: From PheWAS to PheRS [0.03%]
基于电子健康档案的Phecode研究：从全表型关联分析到全表型相关研究
Lisa Bastarache
Lisa Bastarache
Electronic health records (EHRs) are a rich source of data for researchers, but extracting meaningful information out of this highly complex data source is challenging. Phecodes represent one strategy for defining phenotypes for research us...
Irene Y Chen,Shalmali Joshi,Marzyeh Ghassemi et al.
Irene Y Chen et al.
Machine learning can be used to make sense of healthcare data. Probabilistic machine learning models help provide a complete picture of observed data in healthcare. In this review, we examine how probabilistic machine learning can advance h...
Yoo-Ah Kim,Mark D M Leiserson,Priya Moorjani et al.
Yoo-Ah Kim et al.
Mutations are the driving force of evolution, yet they underlie many diseases, in particular, cancer. They are thought to arise from a combination of stochastic errors in DNA processing, naturally occurring DNA damage (e.g., the spontaneous...