Jamie R Robinson,Wei-Qi Wei,Dan M Roden et al.
Jamie R Robinson et al.
The rise in available longitudinal patient information in electronic health records (EHRs) and their coupling to DNA biobanks has resulted in a dramatic increase in genomic research using EHR data for phenotypic information. EHRs have the b...
Spatial Metabolomics and Imaging Mass Spectrometry in the Age of Artificial Intelligence [0.03%]
人工智能时代的空间代谢组学和成像质谱技术
Theodore Alexandrov
Theodore Alexandrov
Spatial metabolomics is an emerging field of omics research that has enabled localizing metabolites, lipids, and drugs in tissue sections, a feat considered impossible just two decades ago. Spatial metabolomics and its enabling technology-i...
Tiffany J Callahan,Ignacio J Tripodi,Harrison Pielke-Lombardo et al.
Tiffany J Callahan et al.
Knowledge-based biomedical data science involves the design and implementation of computer systems that act as if they knew about biomedicine. Such systems depend on formally represented knowledge in computer systems, often in the form of k...
Deciphering Cell Fate Decision by Integrated Single-Cell Sequencing Analysis [0.03%]
整合单细胞测序分析破解细胞命运决定过程
Sagar,Dominic Grün
Sagar
Cellular differentiation is a common underlying feature of all multicellular organisms through which naïve cells progressively become fate restricted and develop into mature cells with specialized functions. A comprehensive understanding o...
Mining Social Media Data for Biomedical Signals and Health-Related Behavior [0.03%]
社交媒体中的生物医学信号和健康相关行为的挖掘
Rion Brattig Correia,Ian B Wood,Johan Bollen et al.
Rion Brattig Correia et al.
Social media data have been increasingly used to study biomedical and health-related phenomena. From cohort-level discussions of a condition to population-level analyses of sentiment, social media have provided scientists with unprecedented...
Jie Ren,Xin Bai,Yang Young Lu et al.
Jie Ren et al.
Genome and metagenome comparisons based on large amounts of next generation sequencing (NGS) data pose significant challenges for alignment-based approaches due to the huge data size and the relatively short length of the reads. Alignment-f...
Peng Jiang,William R Sellers,X Shirley Liu
Peng Jiang
Despite significant progress in cancer research, current standard-of-care drugs fail to cure many types of cancers. Hence, there is an urgent need to identify better predictive biomarkers and treatment regimes. Conventionally, insights from...
Advances in Electronic Phenotyping: From Rule-Based Definitions to Machine Learning Models [0.03%]
电子表型研究进展：从基于规则的定义到机器学习模型
Juan M Banda,Martin Seneviratne,Tina Hernandez-Boussard et al.
Juan M Banda et al.
With the widespread adoption of electronic health records (EHRs), large repositories of structured and unstructured patient data are becoming available to conduct observational studies. Finding patients with specific conditions or outcomes,...
April Moreno Arellano,Wenrui Dai,Shuang Wang et al.
April Moreno Arellano et al.
Privacyis an important consideration when sharing clinical data, which often contain sensitive information. Adequate protection to safeguard patient privacy and to increase public trust in biomedical research is paramount. This review cover...