Best Practices on Big Data Analytics to Address Sex-Specific Biases in Our Understanding of the Etiology, Diagnosis, and Prognosis of Diseases [0.03%]
大数据分析在解决我们对疾病发病机制、诊断和预后的性别特有偏差方面的最佳实践
Su Golder,Karen O&#x;Connor,Yunwen Wang et al.
Su Golder et al.
A bias in health research to favor understanding diseases as they present in men can have a grave impact on the health of women. This paper reports on a conceptual review of the literature on machine learning or natural language processing ...
Extracellular Vesicle-Based Multianalyte Liquid Biopsy as a Diagnostic for Cancer [0.03%]
基于细胞外囊泡的多重分析液体活检作为癌症诊断工具
Andrew A Lin,Vivek Nimgaonkar,David Issadore et al.
Andrew A Lin et al.
Liquid biopsy is the analysis of materials shed by tumors into circulation, such as circulating tumor cells, nucleic acids, and extracellular vesicles (EVs), for the diagnosis and management of cancer. These assays have rapidly evolved with...
Bioinformatics of Corals: Investigating Heterogeneous Omics Data from Coral Holobionts for Insight into Reef Health and Resilience [0.03%]
珊瑚生物信息学——通过无偏分析造礁珊瑚菌丛的异质组学数据来深入研究珊瑚礁健康和抗逆性
Lenore J Cowen,Hollie M Putnam
Lenore J Cowen
Coral reefs are home to over two million species and provide habitat for roughly 25% of all marine animals, but they are being severely threatened by pollution and climate change. A large amount of genomic, transcriptomic, and other omics d...
Computational Approaches for Understanding Sequence Variation Effects on the 3D Genome Architecture [0.03%]
计算方法研究序列变异对三维基因组结构的影响
Pavel Avdeyev,Jian Zhou
Pavel Avdeyev
Decoding how genomic sequence and its variations affect 3D genome architecture is indispensable for understanding the genetic architecture of various traits and diseases. The 3D genome organization can be significantly altered by genome var...
Heidi Beate Bentzen
Heidi Beate Bentzen
There is a need to share personal data across jurisdictional boundaries. However, the laws regulating such transfers are not harmonized, and sometimes even conflict, causing challenges and occasional data stalls. This review describes the l...
Integration of Protein Structure and Population-Scale DNA Sequence Data for Disease Gene Discovery and Variant Interpretation [0.03%]
蛋白质结构与人口尺度DNA序列数据的整合在疾病基因发现和变异解析中的应用
Bian Li,Bowen Jin,John A Capra et al.
Bian Li et al.
The experimental and computational techniques for capturing information about protein structures and genetic variation within the human genome have advanced dramatically in the past 20 years, generating extensive new data resources. In this...
Genome Privacy and Trust [0.03%]
基因组隐私和信任感
Gamze Gürsoy
Gamze Gürsoy
Genomics data are important for advancing biomedical research, improving clinical care, and informing other disciplines such as forensics and genealogy. However, privacy concerns arise when genomic data are shared. In particular, the identi...
Elise D Flynn,Tuuli Lappalainen
Elise D Flynn
Thousands of common genetic variants in the human population have been associated with disease risk and phenotypic variation by genome-wide association studies (GWAS). However, the majority of GWAS variants fall into noncoding regions of th...
Ruth Nussinov,Hyunbum Jang,Guy Nir et al.
Ruth Nussinov et al.
Three-dimensional protein structural data at the molecular level are pivotal for successful precision medicine. Such data are crucial not only for discovering drugs that act to block the active site of the target mutant protein but also for...
Cotranslational Mechanisms of Protein Biogenesis and Complex Assembly in Eukaryotes [0.03%]
真核生物中蛋白质生物发生和复合物组装的协同翻译机制
Fabián Morales-Polanco,Jae Ho Lee,Natália M Barbosa et al.
Fabián Morales-Polanco et al.
The formation of protein complexes is crucial to most biological functions. The cellular mechanisms governing protein complex biogenesis are not yet well understood, but some principles of cotranslational and posttranslational assembly are ...