Bradley Iott,Matthew Pantell,Julia Adler-Milstein
Bradley Iott
There is currently much interest in screening patients for social drivers of health (SDOHs) to address health-related social needs (HRSNs), prompting clinicians to increasingly document HRSNs in the electronic health record (EHR). SDOH data...
Xin Wang,Mingcheng Hu,Connie W Tsao et al.
Xin Wang et al.
Recent advancements in artificial intelligence (AI) have significantly influenced the field of cardiovascular disease (CVD) analysis, particularly in image-based diagnostics. Our article presents an extensive review of AI applications in im...
Reclaiming Data, Restoring Health: The Indigenous Biomedical Data Science Renaissance [0.03%]
重获数据，恢复健康：土著生物医学数据科学的复兴
Oliver J Bear Don&#x;t Walk Iv,Lauren W Yowelunh McLester-Davis,Dornell Pete et al.
Oliver J Bear Don&#x;t Walk Iv et al.
Indigenous Peoples are leading a renaissance in biomedical data science. Throughout this narrative review, we highlight advancements from leaders in this renaissance across four phases of biomedical data science: ethics and values that info...
Claudèle Lemay-St-Denis,Rachel Kolodny
Claudèle Lemay-St-Denis
The messenger RNA (mRNA) sequence plays a central role in expressing functional proteins from genes. Species-specific nonuniform codon choices influence key processes, including mRNA stability, translation accuracy and efficiency, and cotra...
Exploring Genetic Variations Associated with the Immune Response in Underrepresented Populations [0.03%]
探索少数族裔人群中的免疫反应相关遗传变异
Ana Laura Hernández-Ledesma,Evelia Lorena Coss-Navarrete,Grecia Sevilla-Parra et al.
Ana Laura Hernández-Ledesma et al.
The immune system protects the body through tightly coordinated innate and adaptive responses shaped largely by an individual's genetic background. Genetic variants associated with immune responses provide key pathways underlying disease su...
Sex and the Genome: Divergent Genetic Architecture Across the Human Lifespan [0.03%]
性与基因组：人类生命周期中遗传结构的差异
Jagyashila Das,Pauline Gachanja,Aisha Sallah et al.
Jagyashila Das et al.
Males and females share nearly identical genomes yet exhibit profound differences in disease susceptibility, progression, and treatment response across the lifespan. These sex differences arise from evolutionary conflicts in which genetic v...
Toward Quantitative Domain-Motif Interactomes: State of the Art, Challenges, and Perspectives [0.03%]
朝向定量的领域特异基序互作组学：现状、挑战与展望
Jesús Alvarado Valverde,Katja Luck
Jesús Alvarado Valverde
Protein-protein interactions (PPIs) drive cellular function. Obtaining quantitative maps of protein interactomes is essential for linking genotype to phenotype and predicting cellular outcomes. A large fraction of PPIs are mediated by domai...
Steven Mesquiti,Erik C Nook
Steven Mesquiti
Mental health challenges add immensely to the global burden of disease, yet traditional approaches to psychological assessment and care remain resource intensive and often inaccessible. There is widespread interest in testing whether advanc...
Julian Daniel Sunday Willett,JangKeun Kim,Anurag Sakharkar et al.
Julian Daniel Sunday Willett et al.
Spaceflight exposes humans to unique stressors that remodel biology. Space health is emerging as a data science discipline grounded in multiomic atlases, harmonized biobanks, and open, findable, accessible, interoperable, and reusable (FAIR...
Fold-Switching Proteins Push the Boundaries of Conformational Ensemble Prediction [0.03%]
折叠转换蛋白推动构象集合预测的边界
Myeongsang Lee,Lauren L Porter
Myeongsang Lee
A protein's function depends critically on its conformational ensemble, a collection of energy-weighted structures whose balance depends on temperature and environment. Though recent deep learning methods have substantially advanced predict...