A Rare Case of Primary Pulmonary Choriocarcinoma Metastasizing to the Kidney: Diagnostic and Therapeutic Complexities [0.03%]
原发肺绒癌肾转移一例及相关诊断治疗的复杂性
Zorán Belics,Antónia Fürich,Levente Bogyó et al.
Zorán Belics et al.
Background: Choriocarcinoma is a highly aggressive malignant tumor composed primarily of cytotrophoblast and syncytiotrophoblast cells without villi and is characterized by beta-human chorionic (beta-hCG) gonadotropin pro...
Activation of the NF-ĸB Signaling Pathway by Lactobacillus plantarum and Lactobacillus casei Through Modulation of TLR4 and DC-SIGN Genes in an Oral Squamous Cell Carcinoma Rat Model [0.03%]
植物乳杆菌和干酪乳杆菌通过调节TLR4和DC-SIGN基因在舌鳞状细胞癌大鼠模型中活化NF-κB信号通路
Vahideh Faghanizadeh,Malihe Naderi,Nazila Arbab Soleimani et al.
Vahideh Faghanizadeh et al.
Background: The composition of the oral and intestinal microbiota is believed to contribute to the development of oral cancer (OC). The chronic activation of pattern recognition receptors (PRRs) has been linked to the agg...
Normalization of CEA, CA15-3, and CA27-29 Tumor Markers Following Single Lung Transplant in a Patient With a History of Early-Stage Breast Cancer and Idiopathic Pulmonary Fibrosis: A Case Report [0.03%]
一例特发性肺纤维化合并早期乳腺癌患者的单肺移植术后CEA、CA15-3及CA27-29肿瘤标志物的动态变化：个案报告
Yolcar Chamorro,Charles L Vogel,Ana C Sandoval-Leon
Yolcar Chamorro
Background: The use of serum tumor markers can provide additional information about a patient's response to treatment, but their use has been controversial in the management of breast cancer (BC) because of a lack of stan...
Decoding the Oncogenic Role of USP22 Through Pan-Cancer Genomic and Epigenetic Analysis [0.03%]
泛癌基因组和表观遗传分析解码USP22的致癌作用
Uma Devi A,Prakash Kumar Shukla
Uma Devi A
Background: Ubiquitin-specific protease 22, an important catalytic component of the human SAGA (Spt-Ada-GcN5 Acetyltransferase) complex, regulates the deubiquitination and methylation of histones, which in turn influences...
Virtual Screening of Traditional Chinese Medicine Natural Product Inhibitors Targeting AQP1 for Bladder Cancer [0.03%]
基于AQP1靶点的抗膀胱癌中药小分子虚拟筛选研究
Di Liu,Qing-Yu Zhang
Di Liu
Background: Bladder cancer (BCa) is the most common and representative type of adult urinary tract urothelial cancer, characterized by high incidence and mortality rates. It has become a major disease threatening public h...
Genetic and Immunohistochemical Profiling of Malignant Mesothelioma With Brain Metastasis: A Report of Two Cases [0.03%]
恶性间皮瘤伴脑转移的基因及免疫组化特征分析两例报告
Paul M Harary,Yusuke S Hori,Ruchit Jain et al.
Paul M Harary et al.
Background: Brain metastasis (BM) occurs in < 3% of malignant mesothelioma (MM) cases and is associated with an aggressive disease course. While genomic profiling has provided insight into molecular alterations in MM, the...
Computational Design of an mRNA Vaccine Targeting LRP6 for Triple-Negative Breast Cancer Therapy [0.03%]
计算设计靶向LRP6的mRNA疫苗用于三阴性乳腺癌治疗
Pooriya Teimoori,Mohammadreza Heidari
Pooriya Teimoori
Background: Triple-negative breast cancer (TNBC) presents a poorer prognosis than other breast cancer subtypes, attributed to its aggressive nature and the lack of specific therapeutic interventions. TNBC has high recurre...
Combined Inhibition of ATR and Ribonucleotide Reductase Induces Synergistic Antineoplastic Activity in Osteosarcoma Cells [0.03%]
联合抑制ATR和核糖核苷酸还原酶可诱导骨肉瘤细胞的协同抗肿瘤作用
Natalie Aderhold,Lisa Immesberger,Sabine Becker et al.
Natalie Aderhold et al.
Background: Osteosarcoma is the most common bone cancer in children and young adults. Its prognosis has not improved significantly since the introduction of the chemotherapy regimen established about 40 years ago, highlig...
Clinicopathological and Prognostic Implications of Epithelial-to-Mesenchymal Transition-Related Immunohistochemical Markers in Resectable Pancreatic Cancer: A Retrospective Longitudinal Study [0.03%]
上皮间质转化相关免疫组化标记在可切除胰腺癌中的临床病理及预后意义：回顾性纵向研究
Ahmad Machmouchi,Lama Zahreddine,Jessica Aoun et al.
Ahmad Machmouchi et al.
Background: Pancreatic ductal adenocarcinoma (PDAC) is the sixth leading cause of global cancer death. The process of epithelial-to-mesenchymal transition (EMT) is a key driver of early progression and metastasis in PDAC....
Identification of Critical miRNAs miR-4652 and miR-1304 as Novel Diagnostic Markers for Oral Squamous Cell Carcinoma [0.03%]
口腔鳞状细胞癌新型诊断标志物关键miRNA miR-4652和miR-1304的鉴定
Sara Bagheri Farahani,Ehsan Keramati,Marziyeh Etesami et al.
Sara Bagheri Farahani et al.
Background: Oral squamous cell carcinoma (OSCC) is marked by frequent recurrence rates and an unclear etiology, underscoring the critical need for early detection to improve therapeutic outcomes and reduce healthcare cost...